SCN4A antibody

Principal name

SCN4A antibody

Alternative names for SCN4A antibody

SkM1, Sodium channel protein type 4 subunit alpha, Sodium channel protein type IV subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.4, Sodium channel protein skeletal muscle subunit alpha

SwissProt ID

P15390 (Rat), P35499 (Human)

Gene ID

6329 (SCN4A), 25722 (Scn4a)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E)

Background of SCN4A antibody

Voltage-gated sodium channels (v) are essential for the generation of action potentials and for cell excitability. v channels are activated in response to depolarization and selectively allow flow of + ions. The v channels are classified into two groups according to their sensitivity to Tetrodotoxin (TTX): TTX-sensitive and TTX-resistant channels. Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit isoform is developmentally regulated and tissue specific. To date, nine v α subunits have been cloned and med v1.1-v1.9.4-5 Sodium channels in the adult central nervous system and heart contain β1 through β4 subunits, whereas sodium channels in adult skeletal muscle have only the β1 subunit. The isoform v1.4, is primarily expressed in skeletal muscle. Different missense mutations in the gene for the v1.4 are correlated with several muscular diseases such as, Paramyotonia congenital (PMC), PMC without cold paralysis, potassium-aggravating myotonia, and hyperkalemic periodic paralysis.

General readings

Gershome C, Lin E, Kashihara H, Hove-Madsen L, Tibbits GF. Colocalization of voltage-gated Na+ channels with the Na+/Ca2+ exchanger in rabbit cardiomyocytes during development. Am J Physiol Heart Circ Physiol. 2011 Jan;300(1)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SCN4A antibody

Western blot analysis of rat skeletal muscle lysate: 1. Anti-Nav1.4 antibody , (1:200). 2. Anti-Nav1.4 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

SCN4A antibody

SCN4A Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

SCN4A antibody

Western blot analysis of Nav1.4 expression in MCF7 (A); NIH3T3 (B); H9C2 (C); mouse brain (D) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

SCN4A antibody

Western blot analysis of Nav1.4 expression in MCF7 (A); NIH3T3 (B); H9C2 (C); mouse brain (D) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

SCN4A antibody

Western blot analysis of Nav1.4 expression in MCF7 (A); NIH3T3 (B); H9C2 (C); mouse brain (D) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

SCN4A antibody

SCN4A Rabbit Serum Hu, Ms, Rt P, WB
0.2 ml / €400.00
  Novus Biologicals Inc.

Lysates

Catalog No.    

SCN4A overexpression lysate

SCN4A overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

7 Item(s)

per page
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