SCN8A antibody

Principal name

SCN8A antibody

Alternative names for SCN8A antibody

MED, Nav1.6, Sodium channel protein type 8 subunit alpha, Sodium channel protein type VIII subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.6

SwissProt ID

O88420 (Rat), Q9UQD0 (Human), Q9WTU3 (Mouse)

Gene ID

6334 (SCN8A), 29710 (Scn8a)

Available reactivities

Hu (Human), Can (Canine), Ms (Mouse), Rt (Rat), Bov (Bovine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Frozen Sections (C), Immunoprecipitation (IP)

Background of SCN8A antibody

Voltage-gated sodium channels (V) are essential for the generation of action potentials and for cell excitability. V channels are activated in response to depolarization and selectively allow flow of + ions. To date, nine V α subunits have been cloned and med V1.1-V1.9.4-5 The V channels are classified into two groups according to their sensitivity to Tetrodotoxin (TTX): TTX-sensitive (V1.1, V1.2, V1.3, V1.4, V1.6 and V1.7) and TTX-resistant (V1.5, V1.8 and V1.9). Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. Expression of the α subunit isoform is developmentally regulated and tissue specific. Sodium channels in the adult central nervous system and heart contain β1 through β4 subunits, whereas sodium channels in adult skeletal muscle have only the β1 subunit. V1.6 is highly expressed in adult brain and localized at high density in nodes of Ranvier and axon initial segments and at lower density in dendrites and cell bodies of some neurons. V1.6 channels are also expressed at high levels in cerebellar Purkinje neurons.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SCN8A antibody

  Mouse Monoclonal anti-SCN8A Antibody  
IHC analysis of Nav1.6 using TA309441, tested on mouse brain hippocampus. Neurons with a good granular positivity in the cytoplasm and positivity showing axons. Mouse IgG1 S87A-10 Purified Hu, Ms, Rt C, IP
0.1 mg / €325.00
  OriGene Technologies, Inc.

SCN8A antibody

  Rabbit polyclonal Anti-NaV1.6  
Western blot analysis of rat brain membrane: 1. Anti-Nav1.6 antibody , (1:200). 2. Anti-Nav1.6 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

SCN8A antibody

  Rabbit Polyclonal Anti-SCN8A Antibody  
WB Suggested Anti-SCN8A Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Human Muscle Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

SCN8A antibody

Cerebellar granule cells, 16 days in culture, obtained from wild-type (WT) and Nav1.6-null “Null” mice. K87A/10=green. DAPI=blue. Scale bar = 20 μm. Images courtesy of Drs. L. M. Sharkey and M. H. Meisler, University of Michigan School of Medicine. Mouse IgG1 K87A/10 Supernatant Hu, Ms, Rt C, ICC/IF, IP
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

SCN8A antibody

Cerebellar granule cells, 16 days in culture, obtained from wild-type (WT) and Nav1.6-null “Null” mice. K87A/10=green. DAPI=blue. Scale bar = 20 μm. Images courtesy of Drs. L. M. Sharkey and M. H. Meisler, University of Michigan School of Medicine. Mouse IgG1 K87A/10 Purified Hu, Ms, Rt C, ICC/IF, IP
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

SCN8A antibody

SCN8A Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SCN8A (Myc-DDK tagged) - Human sodium channel, voltage gated, type VIII, alpha subunit (SCN8A), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, SCN8A (Myc-DDK tagged) - Human sodium channel, voltage gated, type VIII, alpha subunit (SCN8A), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €2,280.00
  OriGene Technologies, Inc.

7 Item(s)

per page
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