SCN8A antibody

Principal name

SCN8A antibody

Alternative names for SCN8A antibody

MED, Nav1.6, Sodium channel protein type 8 subunit alpha, Sodium channel protein type VIII subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.6

SwissProt ID

O88420 (Rat), Q9UQD0 (Human), Q9WTU3 (Mouse)

Gene ID

6334 (SCN8A), 29710

Available reactivities

Hu (Human), Can (Canine), Ms (Mouse), Rt (Rat), Bov (Bovine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Frozen Sections (C), Paraffin Sections (P), Immunoprecipitation (IP)

Background of SCN8A antibody

Voltage-gated sodium channels (V) are essential for the generation of action potentials and for cell excitability. V channels are activated in response to depolarization and selectively allow flow of + ions. To date, nine V α subunits have been cloned and med V1.1-V1.9.4-5 The V channels are classified into two groups according to their sensitivity to Tetrodotoxin (TTX): TTX-sensitive (V1.1, V1.2, V1.3, V1.4, V1.6 and V1.7) and TTX-resistant (V1.5, V1.8 and V1.9). Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. Expression of the α subunit isoform is developmentally regulated and tissue specific. Sodium channels in the adult central nervous system and heart contain β1 through β4 subunits, whereas sodium channels in adult skeletal muscle have only the β1 subunit. V1.6 is highly expressed in adult brain and localized at high density in nodes of Ranvier and axon initial segments and at lower density in dendrites and cell bodies of some neurons. V1.6 channels are also expressed at high levels in cerebellar Purkinje neurons.

15 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SCN8A antibody

IHC analysis of Nav1.6 using TA309441, tested on mouse brain hippocampus. Neurons with a good granular positivity in the cytoplasm and positivity showing axons. Mouse IgG1 S87A-10 Purified Hu, Ms, Rt C, IP
0.1 mg / €325.00
  OriGene Technologies, Inc.

SCN8A antibody

Western blot analysis of rat brain membrane: 1. Anti-Nav1.6 antibody , (1:200). 2. Anti-Nav1.6 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

SCN8A antibody

WB Suggested Anti-SCN8A Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Human Muscle Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

SCN8A antibody

Cerebellar granule cells, 16 days in culture, obtained from wild-type (WT) and Nav1.6-null “Null” mice. K87A/10=green. DAPI=blue. Scale bar = 20 μm. Images courtesy of Drs. L. M. Sharkey and M. H. Meisler, University of Michigan School of Medicine. Mouse IgG1 K87A/10 Supernatant Hu, Ms, Rt C, ICC/IF, IP
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

SCN8A antibody

Cerebellar granule cells, 16 days in culture, obtained from wild-type (WT) and Nav1.6-null “Null” mice. K87A/10=green. DAPI=blue. Scale bar = 20 μm. Images courtesy of Drs. L. M. Sharkey and M. H. Meisler, University of Michigan School of Medicine. Mouse IgG1 K87A/10 Purified Hu, Ms, Rt C, ICC/IF, IP
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

SCN8A antibody

SCN8A Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

SCN8A antibody

SCN8A Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

SCN8A antibody

Immunofluorescence of monoclonal antibody to SCN8A on NIH/3T3 cell. [antibody concentration 10 ug/ml] Mouse IgG2a 4G7 Purified Hu E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SCN8A antibody

Human NCI-H226; Host: Rabbit . Target Name: SCN8A . Sample Tissue: NCI-H226 . Antibody Dilution: 1.0ug/ml. SCN8A is supported by BioGPS gene expression data to be expressed in NCIH226.; SCN8A antibody - middle region (ARP35227_P050) in Human NCI-H226 cells using Western Blot Rabbit Aff - Purified Can, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

SCN8A antibody

Western blot analysis of Nav1.6 expression in MCF7 (A); Raw264.7 (B); H9C2 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

SCN8A antibody

Western blot analysis of Nav1.6 expression in MCF7 (A); Raw264.7 (B); H9C2 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

SCN8A antibody

Western blot analysis of Nav1.6 expression in MCF7 (A); Raw264.7 (B); H9C2 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

SCN8A antibody

SCN8A Rabbit Purified Hu, Ms, Rt P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SCN8A

SCN8A Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

SCN8A

SCN8A Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

15 Item(s)

per page
  • LinkedIn