SCN9A / PN1 antibody

Principal name

SCN9A / PN1 antibody

Alternative names for SCN9A / PN1 antibody

NENA, NE-Na, Sodium channel protein type 9 subunit alpha, Sodium channel protein type IX subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.7, Neuroendocrine sodium channel, Peripheral sodium channel 1

SwissProt ID

O08562 (Rat), Q15858 (Human), Q28644 (Rabit), Q62205 (Mouse), Q8WWN4 (Human)

Gene ID

6335 (SCN9A), 78956 (Scn9a)

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Mky (Monkey), Bov (Bovine), Can (Canine), Eq (Equine), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Frozen Sections (C), Paraffin Sections (P)

Background of SCN9A / PN1 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.
There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2).
Nav1.7 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Therapeutically, the association of pain insensitivity with the loss of function of a certain sodium channel may have implications. Since Nav1.7 is not present in cardiac muscle or neurons in the central nervous system, blockers of Nav1.7 will not have direct action on these cells and thus can have less side effects than current pain medications. By performing more studies, there is a possibility to develop a new generation of drugs that can reduce the pain intensity in animals (3).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SCN9A / PN1 antibody

Western blot analysis of ND7/23 cell lysate (lanes 1,3) and rat brain membranes (lanes 2,4): 1,2. Anti-Nav1.7 antibody , (1:200). 3,4. Anti-Nav1.7 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

SCN9A / PN1 antibody

Immunohistochemical staining of human duodenum shows cytoplasmic positivity in glandular cells.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only. Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SCN9A / PN1 antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using SCN9A antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

SCN9A / PN1 antibody

Predicted cell location: Cytoplasm. Positive control: Human ovarian and gastric cancer tissue . Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human ovarian cancer tissue using SCN9A antibody at dilution 1/40, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

SCN9A / PN1 antibody

Predicted cell location: Cytoplasm. Positive control: Human brain and ovarian cancer tissue . Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human brain tissue using SCN9A antibody at dilution 1/40, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

SCN9A / PN1 antibody

Western blot analysis of Nav1.7 in CHO cells using a 1:1000 dilution of the antibody Mouse IgG1 S68-6 Purified Hu, Ms, Rt ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SCN9A / PN1 antibody

Anti-SCN9A / Nav1.7 antibody IHC of human small intestine, neuroendocrine cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Bov, Can, Eq, Hu, Mky, Ms, Por, Rb
50 µg / €379.00
  OriGene Technologies, Inc.

SCN9A / PN1 antibody

Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and HEK-293 cells stably expressing Nav1.3, and Nav1.7 and transiently expressing Kv2.1 probed with N68/6 (left) or K58/35 (right) TC supe. Mouse IgG1 N68/6 Supernatant Hu, Ms, Rt C, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

SCN9A / PN1 antibody

Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and HEK-293 cells stably expressing Nav1.3, and Nav1.7 and transiently expressing Kv2.1 probed with N68/6 (left) or K58/35 (right) TC supe. Mouse IgG1 N68/6 Purified Hu, Ms, Rt C, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

SCN9A / PN1 antibody

SCN9A / PN1 Rabbit Purified Hu C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

SCN9A / PN1 antibody

SCN9A / PN1 Mouse IgG2b 5A11 Purified Hu, Rt E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SCN9A / PN1 antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using SCN9A Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P
50 µg / €205.00
  Assay Biotech

SCN9A / PN1 antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using SCN9A Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P
0.1 mg / €310.00
  Assay Biotech

SCN9A / PN1 antibody

Western blot analysis of Nav1.7 expression in MCF7 (A); NIH3T3 (B); H9C2 (C) whole cell lysates. Rabbit Aff - Purified Hu, Mky, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

SCN9A / PN1 antibody

Western blot analysis of Nav1.7 expression in MCF7 (A); NIH3T3 (B); H9C2 (C) whole cell lysates. Rabbit Aff - Purified Hu, Mky, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

SCN9A / PN1 antibody

Western blot analysis of Nav1.7 expression in MCF7 (A); NIH3T3 (B); H9C2 (C) whole cell lysates. Rabbit Aff - Purified Hu, Mky, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

SCN9A / PN1 antibody

Immunohistochemistry: Nav1.7 Antibody [20560002] - Moderate to strong cytoplasmic positivity was seen in most normal tissues. Glandular cells of the gastro-intestinal tract were mostly strongly stained. Strong positivity was also seen in exocrine pancreas, decidual and trophoblastic cells of placenta and neuronal cells in hippocampus and lateral ventricle. Squamous epithelia were weakly positive or negative. Weak to moderate cytoplasmic staining was observed in most malignant tissues. Isolated cases of colo-rectal, endometrial, prostate and cervical cancers were strongly positive. Skin and breast cancers were mainly negative.  Image and statement courtesy of the Human Protein Atlas (HPA). Rabbit Hu E, P, WB
50 µg / €500.00
  Novus Biologicals Inc.

SCN9A / PN1 antibody

SCN9A / PN1 Rabbit Hu C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

SCN9A / PN1 antibody

SCN9A / PN1 Rabbit IgG Aff - Purified Hu, Ms, Rt E, P
0.1 mg / €360.00
  Novus Biologicals Inc.

SCN9A / PN1 antibody

SCN9A / PN1 Rabbit IgG Aff - Purified Hu, Ms, Rt E, P
50 µg / €290.00
  Novus Biologicals Inc.

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