SCUBE3 antibody

Principal name

SCUBE3 antibody

Alternative names for SCUBE3 antibody

CEGF3, Signal peptide CUB and EGF-like domain-containing protein 3

SwissProt ID

Q66PY1 (Mouse), Q8IX30 (Human)

Gene ID

222663 (SCUBE3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of SCUBE3 antibody

SCUBE3 Antibody: SCUBE3 is a member of a family of secreted glycoproteins that contain N-termil EGF-like repeats and C-termil cysteine-rich motifs and CUB domain and is highly expressed in primary osteoblasts and bones, and to a lesser extent in heart (1,2). Other studies have shown that overexpression of SCUBE3 in mice induced cardiac hypertrophy, suggesting that it may also play a role in the regulation of cardiac growth. SCUBE3 has been shown to be an endogenous TGF-beta receptor ligand (3,4) and is thought to promote lung cancer cell mobility and invasiveness. In lung cancer cells, the secreted SCUBE3 protein was cleaved by MMP2 and MMP9, allowing the activation of the TGF-beta receptor, the increase of Smad2/3 transcriptiol activity and the upregulation of expression of proteins such as TGF-beta1, VEGF, Sil, and Slug.

General readings

Wu BT, Su YH, Tsai MT, et al. A novel secreted, cell-surface glycoprotein containing multiple epidermal growth factor-like repeats and one CUB domain is highly expressed in primary osteoblasts and bones. J. Biol. Chem. 2004; 279:37485-90.

15 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SCUBE3 (Center) antibody

Western blot analysis of SCUBE3 in mouse kidney tissue lysate with SCUBE3 antibody at (A) 1 and (B) 2 ug/mL. Rabbit IgG Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SCUBE3 antibody

Immunohistochemistry of SCUBE3 in blood vessel tissue with SCUBE3 antibody at 10 ug/mL. Rabbit IgG Purified Hu P
0.1 mg / €325.00
  OriGene Technologies, Inc.

SCUBE3 antibody

WB Suggested Anti-SCUBE3 Antibody; Titration: 1.0 ug/ml; Positive Control: MCF7 Whole Cell Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

SCUBE3 (Center) Control Peptide

SCUBE3
50 µg / €160.00
  Acris Antibodies GmbH

SCUBE3 antibody

SCUBE3 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

SCUBE3 antibody

SCUBE3 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

SCUBE3 antibody

SCUBE3 Mouse IgG2a 1D6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SCUBE3 antibody

SCUBE3 Rabbit Aff - Purified Hu P
50 µg / €440.00
  Novus Biologicals Inc.

SCUBE3 antibody

Immunohistochemistry-Paraffin: SCUBE3 Antibody [NBP1-85692] Immunohistochemical staining of human esophagus shows strong membranous and cytoplasmic positivity in squamous epithelial cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SCUBE3

SCUBE3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

SCUBE3

SCUBE3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

SCUBE3

SCUBE3 Human Purified
10 µg / €380.00
  Abnova Taiwan Corp.

SCUBE3

SCUBE3 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

SCUBE3

SCUBE3 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

SCUBE3 overexpression lysate

SCUBE3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

15 Item(s)

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