SDHB antibody

Principal name

SDHB antibody

Alternative names for SDHB antibody

SDH, SDH1, Iron-sulfur subunit of complex II, Succinate dehydrogenase [ubiquinone] iron-sulfur subunit mitochondrial

SwissProt ID

A5PL98 (Danre), P21911 (Schpo), P21912 (Human), P21913 (Rat), P21914 (Drome), Q007T0 (Pig), Q3T189 (Bovin), Q9CQA3 (Mouse), Q9YHT2 (Chick)

Gene ID

6390 (SDHB), 67680 (Sdhb), 298596

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Eq (Equine), Fi (Fish), Mky (Monkey), Prim (Primate), GP (Guinea Pig), Gt (Goat), Ye (Yeast), Ze (Zebrafish)

Available hosts

Goat, Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C)

Background of SDHB antibody

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

General readings

Selak MA, Armour SM, MacKenzie ED, Boulahbel H, Watson DG, Mansfield KD, Pan Y, Simon MC, Thompson CB, Gottlieb E. Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell. 2005 Jan;7(1):77-85.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SDHB antibody

  Rabbit Polyclonal Anti-SDHB Antibody  
Host: Rabbit; Target Name: FAM46C; Sample Tissue: Human Fetal Liver; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Gt, Hu, Ms, Rb, Rt, Ye, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

SDHB antibody

  SDHB mouse monoclonal antibody, clone OTI3F5 (formerly 3F5)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-SDHB mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA808102)(1:150) Mouse IgG1 OTI3F5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SDHB antibody

  SDHB mouse monoclonal antibody, clone OTI1H6 (formerly 1H6)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-SDHB mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA808109)(1:150) Mouse IgG1 OTI1H6 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SDHB (C-term) antibody

  Goat Polyclonal Antibody against SDHB  
TA302600 (0.03µg/ml) staining of Human Liver lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SDHB antibody

  Rabbit Polyclonal antibody to SDHB (succinate dehydrogenase complex, subunit B, iron sulfur (Ip))  
SDHB antibody [C2C3], C-term detects SDHB protein by Western blot analysis. A. 30 ug THP-1 whole cell lysate/extract. B. 30 ug NCI-H929 whole cell lysate/extract. 12 % SDS-PAGE. SDHB antibody [C2C3], C-term (TA308686) dilution: 1:1000 Rabbit IgG Aff - Purified Hu, Ms ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SDHB antibody

  Rabbit Polyclonal SDHB Antibody  
Western Blot: SDHB Antibody [TA336808] - Detection of SDHB in mouse kidney lysate. Rabbit Purified Hu, Ms C, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SDHB antibody

  Rabbit Polyclonal Anti-SDHB Antibody  
SDHB Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SDHB antibody

  SDHB mouse monoclonal antibody, clone OTI2A3 (formerly 2A3)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SDHB (RC203182, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SDHB.(1:2000) Mouse IgG2b OTI2A3 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SDHB (271-280) antibody

Human Heart (formalin-fixed, paraffin-embedded) stained with SDHB antibody AP22481PU-N at 5 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat Aff - Purified Can, Eq, Fi, Hu, Mky, Por, Prim E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

SDHB - human gene knockout kit via CRISPR

SDHB - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

SDHB - human gene knockout kit via CRISPR

SDHB - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

SDHB - human gene knockout kit via CRISPR

SDHB - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Sdhb - mouse gene knockout kit via CRISPR

Sdhb - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Sdhb - mouse gene knockout kit via CRISPR

Sdhb - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Sdhb - mouse gene knockout kit via CRISPR

Sdhb - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Sdhb - mouse gene knockout kit via CRISPR

Sdhb - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SDHB (full length, N-term HIS tag)

  Recombinant protein of human succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (SDHB), nuclear gene encoding mitochondrial protein, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug  
SDHB Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
50 µg / €199.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

SDHB overexpression lysate

SDHB overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SDHB (mGFP-tagged) - Human succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (SDHB), nuclear gene encoding mitochondrial protein, 200 uL, >10^7 TU/mL

Lenti ORF particles, SDHB (mGFP-tagged) - Human succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (SDHB), nuclear gene encoding mitochondrial protein, 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, SDHB (Myc-DDK tagged) - Human succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (SDHB), nuclear gene encoding mitochondrial protein , 200 uL, >10^7 TU/mL

Lenti ORF particles, SDHB (Myc-DDK tagged) - Human succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (SDHB), nuclear gene encoding mitochondrial protein , 200 uL, >10^7 TU/mL  
200 µl / €860.00
  OriGene Technologies, Inc.

Items 1 to 20 of 24 total

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