SDHD antibody

Principal name

SDHD antibody

Alternative names for SDHD antibody

SDH4, CybS, QPs3, CII-4, Succinate dehydrogenase complex subunit D, Succinate dehydrogenase [ubiquinone] cytochrome b small subunit mitochondrial, Succinate-ubiquinone reductase membrane anchor subunit, Succinate-ubiquinone oxidoreductase cytochrome b small subunit

SwissProt ID

A5GZW8 (Pig), O14521 (Human), Q5G2C6 (Sheep), Q5ZIS0 (Chick), Q6PCT8 (Rat), Q95123 (Bovin), Q9CXV1 (Mouse), Q9P7X0 (Schpo), Q9VCI5 (Drome)

Gene ID

6392 (SDHD)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of SDHD antibody

SDHD Antibody: The mitochondrial succite dehydrogese complex subunit D (SDHD) is one of four proteins that make up the tricarboxylic cycle enzyme succite dehydrogese (SCH). Studies have shown that mutations in SDHD often leads to hereditary paragangliomas, usually benign tumors of the autonomic nervous system, suggesting that SDHD also plays a role as a tumor-suppressor gene. In one family with a nonsense mutation (R22X) in the SDHD gene, a loss of heterozygosity was found in the paragangliomas, and within these tumors the enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished. Furthermore, high levels of angiogenic factors EPAS1 and VEGF was observed, which may stimulate tumor growth.

General readings

Baysal BE, Ferrell RE, Willett-Brozick JE, et al. Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. Science 2000; 287:848-51.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SDHD (Center) antibody

Western blot analysis of SDHD in EL4 cell lysate with SDHD antibody at (A) 1 and (B) 2 ug/mL. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SDHD (N-term) antibody

Immunohistochemistry analysis in Formalin Fixed, Paraffin Embedded Human kidney tissue  stained with SDHD Antibody (N-term) Cat.-No AP53823PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of SDHD Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu F, ICC/IF, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

SDHD (Center) Control Peptide

SDHD
50 µg / €160.00
  Acris Antibodies GmbH

SDHD antibody

SDHD Mouse IgG2b 3F4 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SDHD antibody

Immunohistochemistry-Paraffin: SDHD Antibody [NBP1-92372] Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SDHD

SDHD Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

SDHD

SDHD Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

SDHD

SDHD Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

SDHD

SDHD Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

SDHD overexpression lysate

SDHD overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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