SEC23A antibody

Principal name

SEC23A antibody

Alternative names for SEC23A antibody

SEC23-related protein A, COPII, Coat Protein 2, Protein transport protein Sec23A

SwissProt ID

A2VDL8 (Bovin), Q01405 (Mouse), Q15436 (Human), Q5ZK03 (Chick), Q7SZE5 (Danre)

Gene ID

10484 (SEC23A), 20334 (Sec23a)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Eq (Equine), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Goat

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of SEC23A antibody

The regulation of intracellular vesicular trafficking is mediated by specific families of proteins that are involved in vesicular budding, translocation, and fusion with target membranes. The protein trafficking between endoplasmic reticulum (ER) and Golgi apparatus is mediated by two distinct membrane coat complexes, COPI and COPII (1). Two Coat protein II (COPII) proteins are necessary to generate secretory vesicles at the endoplasmic reticulum. COPI consist of 7 protein subunits includinga, b, b1, d, e, d, z. COPI is also responsible for the retrograde golgi to ER transport f dilysine-tagged proteins (2). Sec23A is a functional human counter part of the yeast COPII component Sec23p which suggests that it plays similar role in the mammalian protein export from ER. Both Sec 23 isoforms (Sec23A and Sec23B) have similar molecular weight 85 kDa and are co-expressed in many human tissues at varying levels of expression. In yeast, the Sec24p protein is the only COPII component in which two close orthologues have been identified. Sec-23p is a component of coat protein II (COPII) coated vesicles involved in protein export from the endoplasmic reticulum (Mizoguchi et. al., 2000). The COPII is required for the vesicle budding from the endoplasmic reticulum and is consist of two heterodimeric subcomplexes, Sec23p/Sec24p and Sec13p/Sec31p and a small GTPase Ser1p (Higashio et al., 2000). Recent data also suggest that Sec23p/Sec24p complexes are in addition to its role in the shaping up of the vesicle, the Sec23-24p complex may be implicated in cargo selection and trafficking of the amount of cargo with in the cells. Two Sec23p antibodies were generated in rabbits against synthetic peptides from the unique sequence to Sec23 protein.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SEC23A antibody

  Goat Anti-SEC23A Antibody  
(2ug/ml) staining of NIH3T3 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Eq, Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

Sec23a - mouse gene knockout kit via CRISPR

Sec23a - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Sec23a - mouse gene knockout kit via CRISPR

Sec23a - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Sec23a - mouse gene knockout kit via CRISPR

Sec23a - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Sec23a - mouse gene knockout kit via CRISPR

Sec23a - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SEC23A

  Recombinant protein of human Sec23 homolog A (S. cerevisiae) (SEC23A)  
SEC23A Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

SEC23A overexpression lysate

SEC23A overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SEC23A (mGFP-tagged) - Human Sec23 homolog A (S. cerevisiae) (SEC23A), 200 uL, >10^7 TU/mL

Lenti ORF particles, SEC23A (mGFP-tagged) - Human Sec23 homolog A (S. cerevisiae) (SEC23A), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, SEC23A (Myc-DDK tagged) - Human Sec23 homolog A (S. cerevisiae) (SEC23A) , 200 uL, >10^7 TU/mL

Lenti ORF particles, SEC23A (Myc-DDK tagged) - Human Sec23 homolog A (S. cerevisiae) (SEC23A) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

9 Item(s)

per page
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