Securin / PTTG1 antibody
Principal name
Securin / PTTG1 antibody
Alternative names for Securin / PTTG1 antibody
PTTG, EAP1, TUTR1, Pituitary tumor-transforming gene 1 protein, Esp1-associated protein, Tumor-transforming protein 1
Ncbi ID
9606, NP_004210, NP_004210.1, NP_001124526.1, NM_022391, NM_004219
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), ELISA (detection) (E(detection)), Frozen Sections (C)
Background of Securin / PTTG1 antibody
PTTG1 is a homolog of yeast securing proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. PTTG1 has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. PTTG1 contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.
General readings
1. Herman-Antosiewicz, A., et al., Mol. Cancer Ther. 6, 1249-1261 (2007)
2. Toyoda, Y., et al., Mol. Biol. Cell 17, 2287-2302 (2006)
3. Gururaja, T. L., et al., Clin. Cancer Res. 12, 3831-3842 (2006)
4. Wang, H., et al., Genes. Dev. 15, 1361-1372 (2001)
5. Zou, H., et al., Science 285, 418-422 (1999)
Clone DCS-280 is used in the reference 1-3.














Primary Antibodies
Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
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AP06655PU-N | PTTG1/2/3 antibody |
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Rabbit | Aff - Purified | Hu | ICC/IF, P, WB |
0.1 mg /
€350.00
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Acris Antibodies GmbH | |||||||
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TA312966 | Securin / PTTG1 antibody |
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Rabbit polyclonal anti-PTTG1 antibody | |||||||
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Rabbit | IgG | Purified | Hu | E, ICC/IF, WB |
0.1 ml /
€335.00
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OriGene Technologies, Inc. | |||||||
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TA322776 | Securin / PTTG1 antibody |
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Anti-PTTG1 Rabbit Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | E, P |
0.1 ml /
€335.00
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OriGene Technologies, Inc. | |||||||
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TA322777 | Securin / PTTG1 antibody |
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Anti-PTTG1 Rabbit Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | E, P |
0.1 ml /
€335.00
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OriGene Technologies, Inc. | |||||||
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TA347554 | Securin / PTTG1 antibody |
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Rabbit Polyclonal Anti-PTTG1 Antibody | |||||||
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Rabbit | IgG | Purified | Hu | WB |
0.1 mg /
€335.00
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OriGene Technologies, Inc. | |||||||
AM00356AF-N | Securin / PTTG1 antibody |
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Mouse | IgG2a | DCS-280 | Azide Free | Hu, Ms, Rt | ICC/IF, IP, P, WB |
0.1 mg /
€360.00
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Acris Antibodies GmbH | |||||||
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AP23984PU-N | Securin / PTTG1 (148-160) antibody |
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Goat | IgG | Aff - Purified | Elephant, Hu, Mky, Ms | P |
50 µg /
€380.00
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Acris Antibodies GmbH | |||||||
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AP55262SU-N | Securin / PTTG1 antibody |
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Rabbit | Serum | Hu | C, E, WB |
0.2 ml /
€400.00
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Acris Antibodies GmbH | |||||||
C10252-1 | Securin / PTTG1 antibody |
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Rabbit | Aff - Purified | Hu | E, ICC/IF, WB |
50 µg /
€230.00
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Assay Biotech | |||||||
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C10252-2 | Securin / PTTG1 antibody |
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Rabbit | Aff - Purified | Hu | E, ICC/IF, WB |
0.1 mg /
€330.00
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Assay Biotech | |||||||
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CRISPR
Catalog No. | Species | Donor Vector | |
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KN314249 | Pttg1 - mouse gene knockout kit via CRISPR |
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Mouse | GFP-Puro |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN314249BN | Pttg1 - mouse gene knockout kit via CRISPR |
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Mouse | mBFP-Neo |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN314249LP | Pttg1 - mouse gene knockout kit via CRISPR |
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Mouse | Luciferase-Puro |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN314249RB | Pttg1 - mouse gene knockout kit via CRISPR |
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Mouse | RFP-BSD |
1 kit /
€1,290.00
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OriGene Technologies, Inc. |
Proteins & Growth Factors
Catalog No. | Species | Pres. | Purity | Source | |
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TP311038 | Securin / PTTG1 |
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Recombinant protein of human pituitary tumor-transforming 1 (PTTG1) | |||||
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Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€680.00
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OriGene Technologies, Inc. | |||||
AR09247PU-L | Securin / PTTG1 (1-202, His-tag) |
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Human | Purified | > 80 % by SDS - PAGE | E. coli |
0.5 mg /
€1,000.00
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Acris Antibodies GmbH | |||||
AR09247PU-N | Securin / PTTG1 (1-202, His-tag) |
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Human | Purified | > 80 % by SDS - PAGE | E. coli |
0.1 mg /
€370.00
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Acris Antibodies GmbH |
Human Lenti ORF Particles
Catalog No. | ||
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RC211038L2V | Lenti ORF particles, PTTG1 (mGFP-tagged) - Human pituitary tumor-transforming 1 (PTTG1), 200 uL, >10^7 TU/mL |
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200 µl /
€907.00
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OriGene Technologies, Inc. | ||
RC211038L1V | Lenti ORF particles, PTTG1 (Myc-DDK tagged) - Human pituitary tumor-transforming 1 (PTTG1) , 200 uL, >10^7 TU/mL |
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200 µl /
€804.00
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OriGene Technologies, Inc. | ||
Rat Lenti ORF Particles
Catalog No. | ||
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RR214617L2V | Lenti ORF particles, Pttg1 (GFP-tagged ORF) - Rat pituitary tumor-transforming 1 (Pttg1), 200 uL, >10^7 TU/mL |
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200 µl /
€907.00
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OriGene Technologies, Inc. | ||