Securin / PTTG1 antibody

Principal name

Securin / PTTG1 antibody

Alternative names for Securin / PTTG1 antibody

PTTG, EAP1, TUTR1, Pituitary tumor-transforming gene 1 protein, Esp1-associated protein, Tumor-transforming protein 1

SwissProt ID

O95997 (Human), P97613 (Rat), Q3SZY3 (Bovin), Q9BDP6 (Pig), Q9CQJ7 (Mouse)

Gene ID

9232 (PTTG1), 1459232 (Q971Z4)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Por (Porcine), Rt (Rat)

Available hosts

Mouse, Rabbit, Goat

Available applications

Paraffin Sections (P), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), ELISA (detection) (E(detection)), Frozen Sections (C)

Background of Securin / PTTG1 antibody

PTTG1 is a homolog of yeast securing proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. PTTG1 has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. PTTG1 contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.

General readings

1. Herman-Antosiewicz, A., et al., Mol. Cancer Ther. 6, 1249-1261 (2007)
2. Toyoda, Y., et al., Mol. Biol. Cell 17, 2287-2302 (2006)
3. Gururaja, T. L., et al., Clin. Cancer Res. 12, 3831-3842 (2006)
4. Wang, H., et al., Genes. Dev. 15, 1361-1372 (2001)
5. Zou, H., et al., Science 285, 418-422 (1999)
Clone DCS-280 is used in the reference 1-3.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PTTG1/2/3 antibody

Immunohistochemistry (IHC) analyzes of PTTG1/2/3 antibody (Cat.-No.: AP06655PU-N) in paraffin-embedded human testis tissue. Rabbit Aff - Purified Hu ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Securin / PTTG1 antibody

Human rectal carcinoma stained with anti-Pds1 antibody Rabbit Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

Securin / PTTG1 antibody

Human rectal carcinoma stained with anti-Pds1 antibody Rabbit Purified Hu P
1 ml / €520.00
  Acris Antibodies GmbH

Securin / PTTG1 antibody

Human rectal carcinoma stained with anti-Pds1 antibody Rabbit Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

Securin / PTTG1 antibody

Western blot analysis of extracts from 293 cells, Jurkat cells and HepG2 cells, using PTTG1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Securin / PTTG1 antibody

Predicted cell location: Cytoplasm,Nucleus. Positive control: Human breast and lung cancer tissue . Recommended dilution: 1/100-300  The image on the left is immunohistochemistry of paraffin-embedded human breast cancer tissue using PTTG1 antibody at dilution 1/60, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Securin / PTTG1 antibody

Predicted cell location: Cytoplasm,Nucleus. Positive control: Human colon and gastric cancer tissue . Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human colon cancer tissue using PTTG1 antibody at dilution 1/30, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Securin / PTTG1 antibody

Western blot analysis on Jurkat and K562 cell lysate using PTTG1 Antibody Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Securin / PTTG1 antibody

Figure 1. AM00536AF-N Securin antibody staining of a squamous epithelium
of Human tonsil Paraffin Embedded Section. Mouse IgG2a DCS-280 Azide Free Hu, Ms, Rt ICC/IF, IP, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Securin / PTTG1 (148-160) antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat IgG Aff - Purified Can, Elephant, Hu, Mky, Prim P
50 µg / €470.00
  Acris Antibodies GmbH

Securin / PTTG1 antibody

Securin / PTTG1 Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

Securin / PTTG1 antibody

Securin / PTTG1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Securin / PTTG1 antibody

Securin / PTTG1 Mouse Serum Hu E(detection), ICC/IF
50 µl / €370.00
  Abnova Taiwan Corp.

Securin / PTTG1 antibody

Securin / PTTG1 Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

Securin / PTTG1 antibody

Securin / PTTG1 Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Securin / PTTG1 antibody

Securin / PTTG1 Mouse IgG 1D9 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Securin / PTTG1 antibody

Securin / PTTG1 Mouse IgG2a 3F9 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

Securin / PTTG1 antibody

Securin / PTTG1 Mouse IgG2b 1G10 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

Securin / PTTG1 antibody

Securin / PTTG1 Mouse IgG2a 3H8 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

Securin / PTTG1 antibody

Detection limit for recombinant GST tagged PTTG1 is approximately 0.03ng/ml as a capture antibody. Mouse IgG2b 2C3 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

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