SENP6 antibody

Principal name

SENP6 antibody

Alternative names for SENP6 antibody

Sentrin-specific protease 6, KIAA0797, SSP1, SUSP1, Sentrin/SUMO-specific protease SENP6, SUMO-1-specific protease 1

SwissProt ID

Q6P7W0 (Mouse), Q9GZR1 (Human)

Gene ID

26054 (SENP6)

Available reactivities

Hu (Human), Can (Canine), Ms (Mouse), Rt (Rat), Bov (Bovine), Eq (Equine), Por (Porcine)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of SENP6 antibody

SENP6 is a UBL-specific protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. It does not seem to be involved in the processing of full-length SUMO proteins to their mature forms. SENP6 deconjugates SUMO1 from RXRA, leading to transcriptiol activation. It may act preferentially on substrates containing 3 or more SUMO2 or SUMO3 moieties.Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-termil glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]).[supplied by OMIM].

General readings

Choi SJ, Chung SS, Rho EJ, Lee HW, Lee MH, Choi HS, Seol JH, Baek SH, Bang OS, Chung CH.
Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1.
J Biol Chem. 2006 Oct 13;281(41):30669-77. Epub 2006 Aug 15.
PMID: 16912044

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SENP6 antibody

TA303331 (0.5µg/ml) staining of HeLa cell nuclear lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SENP6 antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using SENP6 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

SENP6 antibody

Sample Type: 1.Rat Testis cells (200ug); Primary Dilution: 1: 1000; Secondary Antibody: alkaline phosphatase-conjugated anti-rabbit; Secondary Dilution: 1: 1000; Image Submitted by: Andreia Carvalho; IBMC-OBF, Portugal See Customer Feedback tab for detail Rabbit IgG Purified Bov, Eq, Hu, Por WB
50 µg / €325.00
  OriGene Technologies, Inc.

SENP6 antibody

Immunohistochemistry (IHC) analyzes of SENP6 antibody (Cat.-No.: AP06460PU-N) in paraffin-embedded human lung carcinoma tissue. Rabbit Aff - Purified Hu P
0.1 mg / €350.00
  Acris Antibodies GmbH

SENP6 (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

SENP6 antibody

SENP6 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

SENP6 antibody

Immunoperoxidase of monoclonal antibody to SENP6 on formalin-fixed paraffin-embedded human stomach. [antibody concentration 3 ug/ml] Mouse IgG2a 4B7 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SENP6 antibody

Formalin-fixed and paraffin-embedded human breast cancer tissue reacted with SENP6 polyclonal antibody ( Cat # PAB1849 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

SENP6 antibody

SENP6 Goat Hu, Ms E
0.1 mg / €390.00
  Abnova Taiwan Corp.

SENP6 antibody

SENP6 polyclonal antibody ( Cat # PAB7602 ) ( 0.5 µg/ml ) staining of HeLa cell nuclear lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

SENP6 antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using SENP6 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, P
50 µg / €205.00
  Assay Biotech

SENP6 antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using SENP6 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, P
0.1 mg / €310.00
  Assay Biotech

SENP6 antibody

Rat; . Sample Type: 1.Rat Testis cells (200ug) . Primary Dilution: 1:1000. Secondary Antibody: alkaline phosphatase-conjugated anti-rabbit. Secondary Dilution: 1:1000. Image Submitted by: Andreia Carvalho. IBMC-OBF, Portugal . See Customer Feedback tab for detailed information.. .; SENP6 antibody - C-terminal region (ARP50600_P050) in Rat cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

SENP6 antibody

NBP1-00238 (0.5ug/ml) staining of HeLa cell nuclear lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence Goat IgG Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

SENP6 antibody

Immunohistochemistry-Paraffin: SENP6 Antibody [NBP1-82958] - Immunohistochemical staining of human vulva/anal skin shows strong nuclear positivity in squamous epithelial cells. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SENP6

SENP6 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

SENP6

SENP6 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

17 Item(s)

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