SENP8 antibody

Principal name

SENP8 antibody

Alternative names for SENP8 antibody

Sentrin-specific protease 8, Deneddylase-1, DEN1, NEDP1, PRSC2, Sentrin/SUMO-specific protease SENP8, Protease cysteine 2, NEDD8-specific protease 1

SwissProt ID

Q5FVJ8 (Rat), Q96LD8 (Human), Q9D2Z4 (Mouse)

Gene ID

123228 (SENP8), 71599 (Senp8), 315723

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of SENP8 antibody

SUMO (small ubiquitin-related modifier), a member of the ubiquitin-like protein family, regulates diverse cellular functions of a variety of target proteins including transcription, DNA repair, nucleocytoplasmic trafficking and chromosome segregation. SUMO precursor proteins undergo cleavage of the residues after the “GG” region by SUMO-specific proteases in maturation. This cleavage of the precursor is a prerequisite for subsequent sumoylation. The sentrin-specific (or SUMO-specific) protease (SENP) proteins belong to the peptidase C48 family and include SENP1-3 and SENP5-8. SENP1, SENP2 and SENP3 degrade UBL1 and SMT3H2 conjugates and subsequently release the monomers from sumoylated substrates. HIPK2 is a desumoylation target for SENP1 which shuttles between the cytoplasm and the nucleus. Mutation analyses reveal that SENP1 contains the nuclear export sequence (NES) within the extreme carboxyl-terminal region, and SENP1 is exported to the cytoplasm in a NES-dependent manner. SENP2 has been implicated as a downregulator of CTNNB1 levels and may therefore be a modulator of the Wnt pathway. SUMO protease SENP3 reverses the sumoylation of MEF-2 to augment its transcriptional and myogenic activities. SENP5 localizes to the nucleolus and preferentially processes SUMO-3. It is thought to play a role in mitosis and/or cytokinesis. SENP6 localizes to the cytoplasm and releases SUMO-1. Expression of SENP6 is higher in reproductive organs, indicating that it may mediate processes related to reproduction. SENP8 is involved in the release of sentrins.

General readings

Reverter D., et al. (2004) Atructure. 12(8):1519-31.
Shen LN., et al. (2005) EMBO J. 24(7):1341-51.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SENP8 antibody

  Rabbit polyclonal anti-SENP8 antibody  
Western blot analysis of extracts from HuvEc cells, using SENP8 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SENP8 antibody

  Rabbit Polyclonal Anti-SENP8 Antibody  
Western blot analysis on HuvEc cell lysate using SENP8 Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SENP8 antibody

  Rabbit Polyclonal Anti-SENP8 rabbit polyclonal antibody  
Gel: 12%SDS-PAGE,Lysate: 40 ug,Lane 1-6: 293T cells, Hela cells, Lovo cells, Raji cells, HUEVC cells, Mouse spleen tissue,Primary antibody: (SENP8 Antibody) at dilution 1/600 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 20 seconds Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SENP8 antibody

  SENP8 mouse monoclonal antibody, clone OTI3E4 (formerly 3E4)  
Immunohistochemical staining of paraffin-embedded Human thyroid tissue within the normal limits using anti-SENP8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA804753) Mouse IgG1 OTI3E4 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SENP8 antibody

Immunohistochemistry (IHC) analyzes of SENP8 antibody (Cat.-No.: AP06462PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

SENP8 (N-term) antibody

Western blot analysis of SENP8 polyclonal antibody (Cat. #AP11263PU-N) in mouse spleen lysate. SENP8 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. Rabbit Ig Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

SENP8 (C-term) antibody

Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

SENP8 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using SENP8 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €230.00
  Assay Biotech

SENP8 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using SENP8 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

SENP8 - human gene knockout kit via CRISPR

SENP8 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Senp8 - mouse gene knockout kit via CRISPR

Senp8 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Senp8 - mouse gene knockout kit via CRISPR

Senp8 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Senp8 - mouse gene knockout kit via CRISPR

Senp8 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Senp8 - mouse gene knockout kit via CRISPR

Senp8 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SENP8

  Recombinant protein of human SUMO/sentrin specific peptidase family member 8 (SENP8)  
SENP8 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

SENP8 (transcript variant 1)

  Recombinant protein of human SUMO/sentrin specific peptidase family member 8 (SENP8), transcript variant 1.  
SENP8 Human > 80 %
Preparation: or Add: Recombint proteins was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

SENP8 (transcript variant 1)

  Recombinant protein of human SUMO/sentrin specific peptidase family member 8 (SENP8), transcript variant 1.  
SENP8 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
10 µg / €299.00
  OriGene Technologies, Inc.

SENP8 (1-212, His-tag)

SENP8 Human Purified > 95 % E. coli
0.5 mg / €750.00
  Acris Antibodies GmbH

SENP8 (1-212, His-tag)

SENP8 Human Purified > 95 % E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

SENP8 overexpression lysate

SENP8 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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