Serotonin receptor 1A (HTR1A) antibody

Principal name

Serotonin receptor 1A (HTR1A) antibody

Alternative names for Serotonin receptor 1A (HTR1A) antibody

5-hydroxytryptamine receptor 1A, ADRB2RL1, ADRBRL1, 5-HT1A, 5-HT-1A

SwissProt ID

P08908 (Human), P19327 (Rat), Q0EAB6 (Horse), Q64264 (Mouse), Q6XXX9 (Canfa), Q98998 (Xenla)

Gene ID

3350 (HTR1A), 24473 (Htr1a), 15550

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Rb (Rabbit)

Available hosts

Rabbit, Mouse, Goat

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Dot blot (Dot), Immunoprecipitation (IP)

Background of Serotonin receptor 1A (HTR1A) antibody

The serotonergic system is involved in both pathophysiology and treatment of addiction, depression or mood disorders, appetite control, cardiovascular function, motility of GI tract and sexual function. Serotonin (5-HT) has long been implicated in a number of neurodevelopmental processes including neuronal cell division, migration, neurite outgrowth, and synapse formation which regulate and control some of the above physiological manifestations. Molecular cloning of 5HT receptors have identified a family of closely related genes that encodes several proteins with extensive splice variants exhibiting high degree of amino acid homology (45%-65%) all in the molecular weight range of 40-60 kDa. In brain the 5HT1A binding sites are tightly coupled to oestrous cycle and sex hormone levels (1). Serotonin receptors, also known as 5HT receptors are G-protein coupled rectors (7 transmembrane domains) that elicit the serotonin mediated effects on the above diverse physiological functions. There are at least 7 members of 5HT receptors (5HT1-5HT7), the 5HT1 is further divided in to 6 subtypes (5HT1A-5HT1F) each with multiple variants expressed as a results of alternate splicing or use of alternate initiation codons. Serotonin is reabsorbed by serotonin reuptake transporter which is coupled to sodium/calcium pump.
5HT1A receptors are grouped among the GPCR with characteristic 7TMD. There are several variants isoform of the 5HT1A receptors (5HT1A-5HT1E). The type if signal transduction could be excitatory or inhibitory depending upon the receptor functional coupling to the signal transduction complex. Certain beta arrestins are co-localized with 5HT receptors, where they act in concert with Bark1 or GRK1 and GRK 2 to regulate the expression of the GPCRs. All 5HT receptor proteins are glycosylated at or near the C-terminus and are present on either cell surface or in intracellular sites. Some transporters exhibit dynamic trafficking between intracellular storage sites and plasma membranes in response to various stimuli. 5HT receptors are believed to be associated with other proteins including members of the dopamine receptors and opiod receptors resulting in a significant increase in their apparent molecular weight.

General readings

Lopez-Figueroa,A.L., et al., (2004) Biol. Psychiatry 55 (3), 225-233.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Serotonin receptor 1A (HTR1A) antibody

(1ug/ml) staining of Mouse Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Serotonin receptor 1A (HTR1A) antibody

Western blot analysis of extracts from HepG2 cells and Jurkat cells, using 5-HT-1A antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Serotonin receptor 1A (HTR1A) antibody

Predicted band size: 46kDa. Positive control: HepG2 cell and Mouse brain tissue lysate. Recommended dilution: 1/1000-5000. (Gel: 8%SDS-PAGE Lane1: HepG2 cell lysate Lane2: Mouse brain tissue lysate Lysates: 30 ug per lane Primary antibody: 1/1000 dilution Secondary antibody: Donkey anti Rabbit IgG - H&L (HRP) at 1/3000 dilution Exposure time: 30 seconds) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Serotonin receptor 1A (HTR1A) antibody

Predicted band size: 46kDa. Positive control: HT-29 cell and Mouse brain tissue lysate. Recommended dilution: 1/1000-5000. (Gel: 8%SDS-PAGE Lane1: HT-29 cell lysate Lane2: Mouse brain tissue lysate Lysates: 30 ug per lane Primary antibody: 1/1500 dilution Secondary antibody: Donkey anti Rabbit IgG - H&L (HRP) at 1/3000 dilution Exposure time: 2 minutes) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Serotonin receptor 1A (HTR1A) antibody

Western blot analysis of mouse brain membrane (lanes 1 and 3) and rat brain membrane (lanes 2 and 4): 1,2. Anti-5-Hydroxytryptamine Receptor 1A antibody , (1:200). 3,4. Anti-5-Hydroxytryptamine Receptor 1A antibody, preincubated with the control peptide antigen Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Serotonin receptor 1A (HTR1A) antibody

HTR1A antibody - N-terminal region validated by WB using primary cultured neurons Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

Serotonin receptor 1A (HTR1A) antibody

WB Suggested Anti-HTR1A Antibody Titration: 0.0625ug/ml; ELISA Titer: 1:62500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Serotonin receptor 1A (HTR1A) antibody

Western blot analysis on HepG2 cell lysate using 5-HT-1A Antibody Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Serotonin receptor 1A (HTR1A) antibody

Western blot analysis of 5-HT-1A expression in HepG2 cells Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Serotonin receptor 1A (HTR1A) antibody

Immunohistochemistry (IHC) analyzes of SR-1A antibody (Cat.-No.: AP06769PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Serotonin receptor 1A (HTR1A) Control Peptide

Serotonin receptor 1A (HTR1A)
0.25 mg / €250.00
  Acris Antibodies GmbH

Serotonin receptor 1A (HTR1A) antibody

Serotonin receptor 1A (HTR1A) Rabbit Aff - Purified Ms, Rt Dot, E, IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Serotonin receptor 1A (HTR1A) antibody

Serotonin receptor 1A (HTR1A) Rabbit Serum Rt E, ICC/IF, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

Serotonin receptor 1A (HTR1A) antibody

Serotonin receptor 1A (HTR1A) Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Serotonin receptor 1A (HTR1A) antibody

Western blot analysis of extracts from HepG2/Jurkat cells, using 5-HT-1A Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €205.00
  Assay Biotech

Serotonin receptor 1A (HTR1A) antibody

Western blot analysis of extracts from HepG2/Jurkat cells, using 5-HT-1A Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €310.00
  Assay Biotech

Serotonin receptor 1A (HTR1A) antibody

Human myometrial; HTR1A antibody - N-terminal region (AVARP13041_P050) validated by WB using primary cultured neurons; HTR1A antibody - N-terminal region (AVARP13041_P050) in Human myometrial cells using Western Blot Rabbit Aff - Purified Hu P, WB
50 µg / €350.00
  AVIVA Systems Biology

Serotonin receptor 1A (HTR1A) antibody

Human Jurkat; WB Suggested Anti-HTR1A Antibody Titration: 0.0625ug/ml. ELISA Titer: 1:62500. Positive Control: Jurkat cell lysate; HTR1A antibody - N-terminal region (AVARP13041_T100) in Human Jurkat cells using Western Blot Rabbit Aff - Purified Hu P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

Serotonin receptor 1A (HTR1A) antibody

Serotonin receptor 1A (HTR1A) Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €290.00
  Boster Immunoleader

Serotonin receptor 1A (HTR1A) antibody

Western blot analysis of 5-HT1A expression in Saos2 (A); Jurkat (B) whole cell lysates. Rabbit Aff - Purified Hu, Rb, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

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