Serotonin receptor 1B (HTR1B) antibody

Principal name

Serotonin receptor 1B (HTR1B) antibody

Alternative names for Serotonin receptor 1B (HTR1B) antibody

HTR1DB, 5-hydroxytryptamine receptor 1B, 5-HT-1D-beta

SwissProt ID

O08892 (Cavpo), P28222 (Human), P28334 (Mouse), P28564 (Rat), P49144 (Rabit), P79399 (Pig), Q0EAB5 (Horse), Q588Y6 (Felca)

Gene ID

3351 (HTR1B), 15551 (Htr1b), 25075

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Bt (Bat), Eq (Equine), Por (Porcine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Serotonin receptor 1B (HTR1B) antibody

The serotonergic system is involved in both pathophysiology and treatment of addiction, depression or mood disorders, appetite control, cardiovascular function, motility of GI tract and sexual function. Serotonin (5-HT) has long been implicated in a number of neurodevelopmental processes including neuronal cell division, migration, neurite outgrowth, and synapse formation which regulate and control some of the above physiological manifestations. Molecular cloning of 5HT receptors have identified a family of closely related genes that encodes several proteins with extensive splice variants exhibiting high degree of amino acid homology (45%-65%) all in the molecular weight range of 40-60 kDa. In brain the 5HT1A binding sites are tightly coupled to oestrous cycle and sex hormone levels (1). Serotonin receptors, also known as 5HT receptors are G-protein coupled rectors (7 transmembrane domains) that elicit the serotonin mediated effects on the above diverse physiological functions. There are at least 7 members of 5HT receptors (5HT1-5HT7), the 5HT1 is further divided in to 6 subtypes (5HT1A-5HT1F) each with multiple variants expressed as a results of alternate splicing or use of alternate initiation codons. Serotonin is reabsorbed by serotonin reuptake transporter which is coupled to sodium/calcium pump.
5HT1A receptors are grouped among the GPCR with characteristic 7TMD. There are several variants isoform of the 5HT1A receptors (5HT1A-5HT1E). The type if signal transduction could be excitatory or inhibitory depending upon the receptor functional coupling to the signal transduction complex. Certain beta arrestins are co-localized with 5HT receptors, where they act in concert with Bark1 or GRK1 and GRK 2 to regulate the expression of the GPCRs. All 5HT receptor proteins are glycosylated at or near the C-terminus and are present on either cell surface or in intracellular sites. Some transporters exhibit dynamic trafficking between intracellular storage sites and plasma membranes in response to various stimuli. 5HT receptors are believed to be associated with other proteins including members of the dopamine receptors and opiod receptors resulting in a significant increase in their apparent molecular weight.

General readings

L, et al., (2004) Biol. Psychiatry 55 (3), 225-233

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Serotonin receptor 1B (HTR1B) antibody

  Goat Polyclonal Antibody against Serotonin receptor 1B / HTR1B  
TA302601 (2µg/ml) staining of Human Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Serotonin receptor 1B (HTR1B) antibody

  Rabbit Polyclonal Anti-5-Hydroxytryptamine Receptor 1B (extracellular)  
Western blot analysis of rat hippocampus lysate: 1. Anti-5-Hydroxytryptamine Receptor 1B (extracellular) antibody, (1:400). 2. Anti-5-Hydroxytryptamine Receptor 1B (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Serotonin receptor 1B (HTR1B) antibody

  Rabbit Polyclonal Anti-HTR1B Antibody  
WB Suggested Anti-HTR1B Antibody Titration: 1.25ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Serotonin receptor 1B (HTR1B) antibody

  Rabbit Polyclonal 5-HT1B Antibody  
Western Blot: 5HT1B Receptor Antibody [TA336338] - Analysis of 5HT1BR in human brain lysate with anti-5-HT1BR pcAb (TA336338). A protein band of approximate molecular weight of 40-41kDa was detected. Rabbit Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Serotonin receptor 1B (HTR1B) (Cytopl. Dom.) antibody

  Rabbit Polyclonal Anti-HTR1B Antibody (Cytoplasmic Domain)  
Anti-5HT1B Receptor antibody IHC of human vascular smooth muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu, Ms, Rt P
50 µg / €400.00
  OriGene Technologies, Inc.

Serotonin receptor 1B (HTR1B) antibody

  Rabbit Polyclonal Anti-HTR1B Antibody (Internal)  
Anti-5HT1B Receptor antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Bt, Eq, Hu, Ms, Por, Rt
50 µg / €400.00
  OriGene Technologies, Inc.

Serotonin receptor 1B (HTR1B) antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using 5-HT-1B Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
50 µg / €230.00
  Assay Biotech

Serotonin receptor 1B (HTR1B) antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using 5-HT-1B Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
0.1 mg / €330.00
  Assay Biotech

Serotonin receptor 1B (HTR1B) antibody

Immunofluorescence analysis of A549 cells, using HTR1B Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
50 µg / €230.00
  Assay Biotech

Serotonin receptor 1B (HTR1B) antibody

Immunofluorescence analysis of A549 cells, using HTR1B Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

HTR1B - human gene knockout kit via CRISPR

HTR1B - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

HTR1B - human gene knockout kit via CRISPR

HTR1B - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

HTR1B - human gene knockout kit via CRISPR

HTR1B - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

HTR1B - human gene knockout kit via CRISPR

HTR1B - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Htr1b - mouse gene knockout kit via CRISPR

Htr1b - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Htr1b - mouse gene knockout kit via CRISPR

Htr1b - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Htr1b - mouse gene knockout kit via CRISPR

Htr1b - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Htr1b - mouse gene knockout kit via CRISPR

Htr1b - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Htr1b (GFP-tagged) - Mouse 5-hydroxytryptamine (serotonin) receptor 1B (Htr1b), 200 uL, >10^7 TU/mL

Lenti ORF particles, Htr1b (GFP-tagged) - Mouse 5-hydroxytryptamine (serotonin) receptor 1B (Htr1b), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Htr1b (Myc-DDK-tagged) - Mouse 5-hydroxytryptamine (serotonin) receptor 1B (Htr1b), 200 uL, >10^7 TU/mL

Lenti ORF particles, Htr1b (Myc-DDK-tagged) - Mouse 5-hydroxytryptamine (serotonin) receptor 1B (Htr1b), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

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