Serotonin receptor 2B (HTR2B) antibody

Principal name

Serotonin receptor 2B (HTR2B) antibody

Alternative names for Serotonin receptor 2B (HTR2B) antibody

5-hydroxytryptamine receptor 2B, 5-HT2B, 5-HT-2B

SwissProt ID

P28286 (Drome), P30994 (Rat), P41595 (Human), P97267 (Cavpo), Q02152 (Mouse), Q29005 (Pig)

Gene ID

3357 (HTR2B)

Available reactivities

Bt (Bat), Bov (Bovine), Chimp (Chimpanzee), Hu (Human), Mky (Monkey), Rt (Rat), Gorilla, Can (Canine), Eq (Equine), Bear, Ms (Mouse)

Available hosts

Rabbit, Mouse

Available applications

Paraffin Sections (P), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Immunoprecipitation (IP)

Background of Serotonin receptor 2B (HTR2B) antibody

5-HT2B, a Serotonin Receptor, activates phospholipase C upon binding serotonin, which results in a rise in intracellular calcium. It is known that 5-HT2B regulates cardiovascular function during development and in adulthood; mice lacking functional 5-HT2B receptors died of heart defects during gestation or neonatally, and adult mutant mice displayed cardiopathy, including myocyte disarray and ventricular dilation. Abnormal vascular proliferation causes an increase in pulmonary blood pressure, which is associated with an increase in 5-HT2B receptor, resulting in the development of pulmonary hypertension. It has also been reported that the 5-HT2B is involved in cell-cycle regulation via interaction with tyrosine kinase pathways. 5-HT2B receptors may have a role in the initiation of migraine headaches, and selective antagonists may prove therapeutic in migraine treatment.
5-HT2B receptor is expressed in many tissues including human liver, kidney, lung, heart, pancreas, spleen, brain, spinal cord, gastrointestinal tract, placenta, and coronary and pulmonary arteries. It has also been reported in embryonic mouse heart and spinal cord. ESTs have been isolated from heart/melanocyte/uterus, kidney, prostate, skin, and thyroid libraries.

General readings

1. Bailey, S.D., et al. Diabetes Care 33(10):2250-2253 (2010). 
2. Roberts, K.E., et al. Gastroenterology 139(1):130-139 (2010).  
3. Svejda, B., et al. Cancer 116(12):2902-2912 (2010).  
4. Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642 (2009). 
5. Tabakoff, B., et al. BMC Biol. 7, 70 (2009).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Serotonin receptor 2B (HTR2B) antibody

Immunohistochemistry: 5HT2B Receptor Antibody - Most normal and malignant cells showed a moderate or strong cytoplasmic staining.  Malignant lymphomas and gliomas were either negative or weakly cytoplasmic stained. Image (malignant lymphoma) was provided courtesy of the Swedish Human Proteome Resource (HPR) Center. Rabbit IgG Purified Hu E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Serotonin receptor 2B (HTR2B) antibody

Mouse Spinal Cord; Immunofluorescence-- 1.3ug/mL; HTR2B antibody - N-terminal region (ARP30716_P050) in Mouse Spinal Cord cells using Immunofluorescence Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Serotonin receptor 2B (HTR2B) antibody

Immunohistochemistry: 5HT2B Receptor Antibody [19510002] - Most normal and malignant cells showed a moderate or strong cytoplasmic staining.  Malignant lymphomas and gliomas were either negative or weakly cytoplasmic stained. Image (malignant lymphoma) was provided courtesy of the Swedish Human Proteome Resource (HPR) Center. Rabbit Hu E, P, WB
50 µg / €440.00
  Novus Biologicals Inc.

Serotonin receptor 2B (HTR2B) antibody

Western blot analysis of extracts from HeLa cells, using 5-HT-2B antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Serotonin receptor 2B (HTR2B) antibody

Immunohistochemistry of paraffin-embedded Human gastic cancer tissue using TA321221(HTR2B Antibody)(left image) at dilution 1/60, the image on the right is treated with the fusion protein.(Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Serotonin receptor 2B (HTR2B) antibody

Western blot analysis of 293T cell using TA321222(HTR2B Antibody) at dilution 1/500 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Serotonin receptor 2B (HTR2B) antibody

Western blot analysis of extracts of various cell lines, using HTR2B antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Serotonin receptor 2B (HTR2B) (2nd Extracell. Dom.) antibody

Anti-5HT2B Receptor antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bov, Bt, Chimp, Gorilla, Hu, Mky, Rt P
50 µg / €379.00
  OriGene Technologies, Inc.

Serotonin receptor 2B (HTR2B) (extracell. dom.) (N-term) antibody

Anti-5HT2B Receptor antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Bt, Can, Eq, Hu, Mky P
50 µg / €379.00
  OriGene Technologies, Inc.

Serotonin receptor 2B (HTR2B) antibody

Anti-5HT2B Receptor antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €379.00
  OriGene Technologies, Inc.

Serotonin receptor 2B (HTR2B) antibody

Western blot analysis of SR-2B Antibody (Cat.-No AP01188PU-N) in extracts from HT-29. Rabbit Aff - Purified Hu ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Serotonin receptor 2B (HTR2B) antibody

HTR2B polyclonal antibody (A01), Lot # 050927JC01 Western Blot analysis of HTR2B expression in HepG2 ( Cat # L019V1 ). Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Serotonin receptor 2B (HTR2B) antibody

Serotonin receptor 2B (HTR2B) Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Serotonin receptor 2B (HTR2B) antibody

Serotonin receptor 2B (HTR2B) Mouse IgG2a 4A4 Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Serotonin receptor 2B (HTR2B) antibody

Serotonin receptor 2B (HTR2B) Mouse IgG2b 4F3 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

Serotonin receptor 2B (HTR2B) antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using 5-HT-2B Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, P, WB
50 µg / €205.00
  Assay Biotech

Serotonin receptor 2B (HTR2B) antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using 5-HT-2B Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, P, WB
0.1 mg / €310.00
  Assay Biotech

Serotonin receptor 2B (HTR2B) antibody

Immunofluorescence analysis of COS7 cells, using HTR2B Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, WB
50 µg / €205.00
  Assay Biotech

Serotonin receptor 2B (HTR2B) antibody

Immunofluorescence analysis of COS7 cells, using HTR2B Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €310.00
  Assay Biotech

Serotonin receptor 2B (HTR2B) antibody

Western blot analysis of 5-HT2B expression in HeLa (A); HT29 (B) whole cell lysates. Rabbit Aff - Purified Hu IP, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

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