Serotonin receptor 3A (HTR3A) antibody

Principal name

Serotonin receptor 3A (HTR3A) antibody

Alternative names for Serotonin receptor 3A (HTR3A) antibody

5-hydroxytryptamine receptor 3A, 5-HT3R, 5-HT3A, Serotonin-gated ion channel receptor

SwissProt ID

O70212 (Cavpo), P23979 (Mouse), P35563 (Rat), P46098 (Human)

Gene ID

3359 (HTR3A), 79246 (Htr3a), 15561

Available reactivities

Hu (Human), Rt (Rat), Prim (Primate), Can (Canine), Ms (Mouse), Bov (Bovine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Rabbit, Goat

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Frozen Sections (C)

Background of Serotonin receptor 3A (HTR3A) antibody

5-Hydroxytryptamine Receptor 3A (5-HT3A) belongs to the super-family of ligand-gated ion channels. Serotonin receptors, other than 5-HT3 subtype belong to the super-family of G-protein coupled receptors. The 5-HT3 receptor is formed by five subunits arranged around a pore forming unit. Receptors could be either monomeric, such as 5-HT3A or heteromeric entities like 5-HT3A/B. Indeed, the type of channel formed displays different pharmacological and electrophysiological characteristics. To date, five 5-HT3 subunits have been identified 5-HT3A-E, which show variability in the N-terminus and in the transmembrane region. 5-HT3A and 5-HT3B are the best characterized among the different types. In general, 5-HT3 receptors are located in the peripheral and central nervous system, in lymphocytes and intestil enterochromaffine cells. In presyptic neurons, activation of these receptors leads to an increase in intracellular Ca2+ (by both influx and mobilization of intracellular stores), and modulates the release of a number of neurotransmitters and neuropeptides. At the postsyptic level, activation leads to membrane depolarization. The 5-HT3A subunit is expressed in GABAergic and enkephalinergic neurons in the spil dorsal horn thereby marking its possible antinociceptive effect. 5-HT3 receptors have become important targets for which to develop treatments regarding irritable bowel syndrome (IBS), side effects resulting from chemotherapeutic treatment, schizophrenia and bipolar disorder.

General readings

Gatt, J.M., et al. Biol. Psychiatry 68(9):818-824(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Gatt, J.M., et al. Depress Anxiety 27(8):752-759(2010)
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
Hammer, C., et al. Pharmacogenomics 11(7):943-950(2010)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Serotonin receptor 3A (HTR3A) antibody

  Rabbit Polyclonal Anti-Htr3a Antibody  
WB Suggested Anti-Htr3a Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Rat Brain Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €360.00
  OriGene Technologies, Inc.

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