Serotonin receptor 3B (HTR3B) antibody

Principal name

Serotonin receptor 3B (HTR3B) antibody

Alternative names for Serotonin receptor 3B (HTR3B) antibody

5-hydroxytryptamine receptor 3B, 5-HT3B, 5-HT3-B

SwissProt ID

O95264 (Human), Q9JHJ5 (Mouse), Q9JJ16 (Rat)

Gene ID

9177 (HTR3B), 58963 (Htr3b)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Enzyme Immunoassay (E)

Background of Serotonin receptor 3B (HTR3B) antibody

5-Hydroxytryptamine Receptor 3B (5-HT3B) belongs to the super-family of ligand-gated ion channels. Serotonin receptors, other than 5-HT3 subtype belong to the super-family of G-protein coupled receptors. The 5-HT3 receptor is formed by five subunits arranged around a pore forming unit. Receptors could be either monomeric, such as 5-HT3A or heteromeric entities like 5-HT3A/B. Indeed, the type of channel formed displays different pharmacological and electrophysiological characteristics. To date, five 5-HT3 subunits have been identified 5-HT3A-E, which show variability in the N-terminus and in the transmembrane region. 5-HT3A and 5-HT3B are the best characterized among the different types. In general, 5-HT3 receptors are located in the peripheral and central nervous system, in lymphocytes and intestil enterochromaffine cells. In presyptic neurons, activation of these receptors leads to an increase in intracellular Ca2+ (by both influx and mobilization of intracellular stores), and modulates the release of a number of neurotransmitters and neuropeptides. At the postsyptic level, activation leads to membrane depolarization. The localization of 5-HT3B subunits is somewhat controversial; some studies show that its expression is restricted to the peripheral nervous system and others show that it is also detected in the brain and in hippocampal neurons. 5-HT3 receptors have become important targets for which to develop treatments regarding irritable bowel syndrome (IBS), side effects resulting from chemotherapeutic treatment, schizophrenia and bipolar disorder.

General readings

Krzywkowski K, Davies PA, Feinberg-Zadek PL, Bräuner-Osborne H, Jensen AA: High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor. Proceedings of the National Academy of Sciences of the United States of America 2008 Jan 105 (2): 722-7. PMID: 18184810

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Serotonin receptor 3B (HTR3B) antibody

TA305926 (1ug/ml) staining of Human Cerebral Cortex lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Serotonin receptor 3B (HTR3B) antibody

Western blot analysis of rat hippocampus lysate (lanes 1 and 3) and mouse brain membrane (lanes 2 and 4): 1-2. Anti-5-Hydroxytryptamine Receptor 3B (extracellular) antibody, (1:200). 3-4. Anti-5-Hydroxytryptamine Receptor 3B (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Serotonin receptor 3B (HTR3B) antibody

WB Suggested Anti-HTR3B Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Por, Rb, Rt ICC/IF, P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Serotonin receptor 3B (HTR3B) antibody

5-HT3B receptor antibody AP54751PU-N staining of Human Kidney Rabbit Purified Hu E, P, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Serotonin receptor 3B (HTR3B) antibody

Western Blot analysis of HTR3B expression in transfected 293T cell line (H00009177-T01) by HTR3B MaxPab polyclonal antibody.

Lane 1: HTR3B transfected lysate(50.30 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Serotonin receptor 3B (HTR3B) antibody

Human Spleen; Rabbit Anti-HTR3B Antibody. Catalog Number: ARP35186. Paraffin Embedded Tissue: Human Spleen. Cellular Data: Spleen cells. Antibody Concentration: 4.0-8.0 ug/ml. Magnification: 400X; HTR3B antibody - N-terminal region (ARP35186_P050) in Human Spleen cells using Immunohistochemistry Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Serotonin receptor 3B (HTR3B)

Serotonin receptor 3B (HTR3B) Human
10 µg / €540.00
  Abnova Taiwan Corp.

7 Item(s)

per page
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