SERPINB2 / PAI2 antibody

Principal name

SERPINB2 / PAI2 antibody

Alternative names for SERPINB2 / PAI2 antibody

Serpin B2, PAI-2, Plasminogen activator inhibitor 2, PLANH2, Placental plasminogen activator inhibitor, Monocyte Arg-serpin, Urokinase inhibitor

SwissProt ID

P05120 (Human), P12388 (Mouse), P29524 (Rat), Q9QWZ6 (Mouse)

Gene ID

5055 (SERPINB2)

Available reactivities

Hu (Human), Ms (Mouse), Prim (Primate), Can (Canine), Rb (Rabbit), Rt (Rat), Mky (Monkey), Bov (Bovine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Sh (Sheep)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Frozen Sections (C), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Flow Cytometry (F)

Background of SERPINB2 / PAI2 antibody

PAI-2 is an inhibitory serpin expressed mainly in keratinocytes, activated monocytes, and placental trophoblasts. It exists predominantly as a 47 kDa nonglycosylated intracellular protein which can be induced to be secreted as 60 kDa glycoprotein. The glycosylated and unglycosylated forms of PAI-2 are equally effective as inhibitors of urokinase-type plasminogen activator (uPA), the only established physiological target of this serpin. PAI-2 has a unique ability to form dormant polymers spontaneously and reversibly under physiological conditions. The physiological relevance of this property, which is neither a consequence of any mutation in the PAI-2 gene nor associated with any known disorder, is still unclear. However, it appears that the formation of intracellular dormant polymers may be important for the controlled release of the inhibitor from PAI-2 producing cells. Plasma levels of PAI-2 are usually low or undetectable, except during pregnancy and in some forms of monocytic leukemia. Secretion of PAI-2 from the placenta normally occurs during the third trimester of pregnancy and accounts for the dramatic increase in PAI-2 levels (up to 250 ng/ml), which are maintained at these levels until postpartum, and then rapidly decline. In addition to its vital role in protecting the placenta from degradation by uPA and/or uPA-activated proteases, PAI-2 has been shown to be essential for the prevention of metastatic spread of neck, lung and breast cancers. The beneficial effect of PAI-2 seen in these studies is presumed to stem from its ability to inhibit uPA-dependent cell dissemination. PAI-2 has also been reported to inhibit keratinocyte proliferation, and to participate in the innate immune response during viral infection.

General readings

Schleuning W.-D., et al, (1987) Mol. Cell. Biol. 7:4564-4567.Ye R.D., et al, (1989) J. Biol. Chem. 264:5495-5502.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SERPINB2 / PAI2 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-SERPINB2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503926) Mouse IgG1 OTI1G3 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SERPINB2 / PAI2 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-SERPINB2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503927) Mouse IgG1 OTI1E3 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SERPINB2 / PAI2 antibody

Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-SERPINB2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503928) Mouse IgG1 OTI1F6 Purified Hu F, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

SERPINB2 / PAI2 antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-SERPINB2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA504005) Mouse IgG1 OTI4E6 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SERPINB2 / PAI2 antibody

Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-SERPINB2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA504056) Mouse IgG1 OTI3H1 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SERPINB2 / PAI2 antibody

WB using Anti-PAI-2 antibody shows detection of endogenous PAI-2 in 50 µg of HeLa whole cell lysates. The band at ~42 kDa (arrowhead) corresponds to PAI-2. Faint non-specific bands are also noted at lower and higher molecular weights positions. Primary antibody was used at 1:500in 5% BLOTTO in PBS reacted overnight at 4?. The membrane was washed and reacted with a 1:5,000 dilution of HRP- conjugated Gt-a-Rabbit IgG (p/n 611-103-122) for 45 min at RTwith ECL used for detection. Rabbit IgG Aff - Purified Hu, Prim E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SERPINB2 / PAI2 antibody

WB Suggested Anti-SERPINB2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Human Liver Rabbit IgG Purified Bov, Can, Eq, GP, Ms, Por, Rb, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

SERPINB2 / PAI2 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SERPINB2 (RC203139, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SERPINB2. Mouse IgG1 OTI4A3 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SERPINB2 / PAI2 antibody

Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 1G3 Purified Hu F, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

SERPINB2 / PAI2 antibody

SERPINB2 / PAI2 Goat Serum Hu C, E, P, WB
0.1 ml / €220.00
  Acris Antibodies GmbH

SERPINB2 / PAI2 antibody

SERPINB2 / PAI2 Goat Serum Hu C, E, P, WB
20 µl / €120.00
  Acris Antibodies GmbH

SERPINB2 / PAI2 antibody

WB using Anti-PAI-2 antibody shows detection of endogenous PAI-2 in 50 µg of HeLa whole cell lysates. The band at ~42 kDa (arrowhead) corresponds to PAI-2. Faint non-specific bands are also noted at lower and higher molecular weights positions. Primary antibody was used at 1:500in 5% BLOTTO in PBS reacted overnight at 4?. The membrane was washed and reacted with a 1:5,000 dilution of HRP- conjugated Gt-a-Rabbit IgG (p/n 611-103-122) for 45 min at RTwith ECL used for detection. Rabbit IgG Aff - Purified Hu, Prim E, WB
25 µl / €190.00
  Acris Antibodies GmbH

SERPINB2 / PAI2 (Center) antibody

Western blot analysis of PAI2 antibody (Center) (AP17618PU-N) in NCI-H460 cell line lysates (35ug/lane). PAI2 (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

SERPINB2 / PAI2 antibody

Immunohistochemistry (IHC) analyzes of PAI-2 antibody (Cat.-No.: AP20791PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

SERPINB2 / PAI2 antibody

Western Blot analysis of SERPINB2 expression in transfected 293T cell line (H00005055-T01) by SERPINB2 MaxPab polyclonal antibody.

Lane 1: SERPINB2 transfected lysate(45.65 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

SERPINB2 / PAI2 antibody

Western Blot analysis of SERPINB2 expression in transfected 293T cell line (H00005055-T02) by SERPINB2 MaxPab polyclonal antibody.

Lane 1: SERPINB2 transfected lysate(46.60 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

SERPINB2 / PAI2 antibody

Detection limit for recombinant GST tagged SERPINB2 is approximately 0.3ng/ml as a capture antibody. Mouse IgG2b 3A9 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

SERPINB2 / PAI2 antibody

Hum. Adult Placenta; Host: Rabbit. Target Name: CHAD . Sample Tissue: Human Adult Placenta . Antibody Dilution: 1.0ug/ml.; SERPINB2 antibody - middle region (ARP56375_P050) in Hum. Adult Placenta cells using Western Blot Rabbit Aff - Purified Can, Hu, Ms, Rb, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

SERPINB2 / PAI2 antibody

SERPINB2 / PAI2 Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

SERPINB2 / PAI2 antibody

Western blot analysis of PAI2 expression in HeLa (A); A431 (B) whole cell lysates. Rabbit Aff - Purified Hu WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

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