SERPINB9 antibody

Principal name

SERPINB9 antibody

Alternative names for SERPINB9 antibody

PI9, PI-9, Serpin B9, Cytoplasmic antiproteinase 3, CAP-3, CAP3, Proteinase inhibitor 9

SwissProt ID

P50453 (Human)

Gene ID

5272 (SERPINB9)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Flow Cytometry (F), Paraffin Sections (P), ELISA (detection) (E(detection)), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of SERPINB9 antibody

PI-9 is a 42kDa intracellular nucleocytoplasmic serpin expressed in cytotoxic lymphocytes (CTLs), natural killer (NK) cells, monocyte-derived dendritic cells (DCs), and to a lesser extent in B cells and myeloid cells. Granzyme B (grB) is a serine protease highly expressed by CTLs and NK cells, which is endocytosed by virusinfected and malignant target cells. The subsequent release of grB from the endocytic vesicles into the cytoplasm of the target cells, triggers grB-mediated apoptosis, through cleavage of various cytoplasmic or nuclear proteins. PI-9, up-regulated in response to grB production and degranulation, has been identified as a potent inhibitor of Granzyme B-mediated apoptosis, providing a vital self-protection mechanism against the premature apoptosis of CTLs and NK cells by grB, which may escape into the cytoplasm of the effector cells themselves.

General readings

Jiang X, Ellison SJ, Alarid ET, Shapiro DJ.
Interplay between the levels of estrogen and estrogen receptor controls the level of the granzyme inhibitor, proteinase inhibitor 9 and susceptibility to immune surveillance by natural killer cells.
Oncogene. 2007 Jan 22
PMID: 17237823

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SERPINB9 antibody

  Goat Polyclonal Antibody against SERPINB9  
TA303212 (0.5µg/ml) staining of Human Placenta lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SERPINB9 antibody

  Rabbit polyclonal anti-SERPINB9 antibody  
Western blot analysis of extracts from Jurkat cells, using SERPINB9 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SERPINB9 antibody

  Mouse monoclonal anti-Proteinase Inhibitor (PI-9) antibody, clone PI9-17  
Western blot analysis of recombinant PI9: Lane 1: 2 µg Lane 2: 5 µg Lane 3: 10 µg Mouse IgG1 PI9-17 Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SERPINB9 antibody

SERPINB9 Mouse IgG1 7D8 Purified Hu F, P, WB
0.1 mg / €250.00
  Acris Antibodies GmbH

SERPINB9 antibody

SERPINB9 Mouse IgG1 7D8 Purified Hu C, F, WB
0.1 mg / €490.00
  Acris Antibodies GmbH

SERPINB9 antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using SERPINB9 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €230.00
  Assay Biotech

SERPINB9 antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using SERPINB9 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

SERPINB9 - human gene knockout kit via CRISPR

SERPINB9 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

SERPINB9 - human gene knockout kit via CRISPR

SERPINB9 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

SERPINB9 - human gene knockout kit via CRISPR

SERPINB9 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

SERPINB9 - human gene knockout kit via CRISPR

SERPINB9 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SERPINB9

  Recombinant protein of human serpin peptidase inhibitor, clade B (ovalbumin), member 9 (SERPINB9)  
SERPINB9 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SERPINB9 (mGFP-tagged) - Human serpin peptidase inhibitor, clade B (ovalbumin), member 9 (SERPINB9), 200 uL, >10^7 TU/mL

Lenti ORF particles, SERPINB9 (mGFP-tagged) - Human serpin peptidase inhibitor, clade B (ovalbumin), member 9 (SERPINB9), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, SERPINB9 (Myc-DDK tagged) - Human serpin peptidase inhibitor, clade B (ovalbumin), member 9 (SERPINB9) , 200 uL, >10^7 TU/mL

Lenti ORF particles, SERPINB9 (Myc-DDK tagged) - Human serpin peptidase inhibitor, clade B (ovalbumin), member 9 (SERPINB9) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

14 Item(s)

per page
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