SERPINC1 / Antithrombin-III antibody

Principal name

SERPINC1 / Antithrombin-III antibody

Alternative names for SERPINC1 / Antithrombin-III antibody

AT3, Serpin C1, ATIII

SwissProt ID

P01008 (Human), P32261 (Mouse), P32262 (Sheep), P41361 (Bovin), P81050 (Mesau), Q03352 (Chick), Q5M7T5 (Rat)

Gene ID

462 (SERPINC1), 11905 (Serpinc1), 304917

Available reactivities

Hu (Human), Mky (Monkey), Can (Canine), Eq (Equine), Fe (Feline), Ms (Mouse), Rt (Rat), Bov (Bovine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Sh (Sheep), Ze (Zebrafish)

Available hosts

Mouse, Sheep, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Functional assay (FN), Western blot / Immunoblot (WB), Immunodiffusion (ID), Paraffin Sections (P), ELISA (detection) (E(detection)), Radioimmunoassay (R), Frozen Sections (C), Flow Cytometry (F)

Background of SERPINC1 / Antithrombin-III antibody

Antithrombin II is a single polypeptide chain glycoprotein (MW 61,000) with a high degree of homology with the alpha-1 antitrypsin. It is a circulating natural anticoagulant acting as a proteinase inhibitor. It is synthesized in the liver and the vascular endothelial cells. In electrophoresis of plasma it migrates in the alpha-1 region and is consumed during coagulation in vivo. Antithrombin III inhibits the action of factors IXa, Xa, XIIa, thombin and kallikrein by forming a stable complex. Heparin acts as a cofactor which greatly increases its inhibitory activities.
Normal adult plasma contain an average of 0.15 mg antithrombin III per ml. This can vary from 75 to 128%. A partial deficiency in antithrombin III activity in the plasma (less than 50%) will result in an increased tendency to recurrent thrombo-enbolism. Several types of congenital deficiency have been reported. Most common type 1 deficiency patients have reduced antithrombin III antigen and activity levels. Heterozygotes have levels of 25 to 50% of normal values.

General readings

(1) Ishiguro K. et al. (2000) J Clin Invest. 106, 873-8.
(2) Vossenaar E.R. et al (2003) Bioessays. 25:1106-
(3) Chang, X. et al. (2005) Rheumatology. 44, 293-298.
(4) Pike, R. N. et al. (1997) J. Biol. Chem. 272, 19652-196655.
(5) Chang, X. et al. (2009) BMC Cancer. 9:40.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SERPINC1 / Antithrombin-III (C-term) antibody

  Rabbit polyclonal SERPINC1 Antibody (C-term)  
Western blot analysis of SERPINC1 Antibody (C-term) (Cat. #TA324863) in mouse liver tissue lysates (35ug/lane). SERPINC1 (arrow) was detected using the purified Pab. Rabbit Hu, Ms WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

SERPINC1 / Antithrombin-III antibody

  Anti-SERPINC1 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm, Nucleus. Positive control: Human thyroid and lung cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using SERPINC1 antibody at dilution 1/15, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

SERPINC1 / Antithrombin-III antibody

  Anti-SERPINC1 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human ovarian cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human ovarian cancer tissue using SERPINC1 antibody at dilution 1/30, on the right is treated with the fusion protein. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

SERPINC1 / Antithrombin-III antibody

  Rabbit anti-SERPINC1 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using SERPINC1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

SERPINC1 / Antithrombin-III antibody

  Rabbit Polyclonal Anti-SERPINC1 Antibody  
WB Suggested Anti-SERPINC1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: PANC1 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Sh, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

SERPINC1 / Antithrombin-III antibody

  Rabbit Polyclonal Anti-Serpinc1 Antibody  
WB Suggested Anti-Serpinc1 Antibody; Titration: 1.0 ug/ml; Positive Control: Mouse Small Intestine Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

SERPINC1 / Antithrombin-III antibody

  SERPINC1 (Antithrombin III) mouse monoclonal antibody, clone OTI8D5 (formerly 8D5)  
Western blot analysis of extracts (10ug) from 10 Human tissue by using anti-SERPINC1 monoclonal antibody at 1:500 (1: Testis; 2: Omentum; 3: Uterus; 4: Breast; 5: Brain; 6: Liver; 7: Ovary; 8: Thyroid gland; 9: colon;10: spleen). Mouse IgG2b OTI8D5 Purified Hu F, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

SERPINC1 / Antithrombin-III antibody

Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 n.a Purified Hu E, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

SERPINC1 / Antithrombin-III antibody

SERPINC1 / Antithrombin-III Sheep Purified Can, Eq, Fe, Hu, Ms, Rt ID, P
1 ml / €380.00
  Acris Antibodies GmbH

SERPINC1 / Antithrombin-III antibody

SERPINC1 / Antithrombin-III Goat Serum Hu C, E, ID
1 ml / €260.00
  Acris Antibodies GmbH

SERPINC1 / Antithrombin-III antibody

SERPINC1 / Antithrombin-III Mouse IgG1 BDI205 Purified Hu, Mky E, FN, WB
0.5 mg / €810.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

Serpinc1 - mouse gene knockout kit via CRISPR

Serpinc1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Serpinc1 - mouse gene knockout kit via CRISPR

Serpinc1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Serpinc1 - mouse gene knockout kit via CRISPR

Serpinc1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Serpinc1 - mouse gene knockout kit via CRISPR

Serpinc1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SERPINC1 / Antithrombin-III

  Recombinant protein of human serpin peptidase inhibitor, clade C (antithrombin), member 1 (SERPINC1)  
SERPINC1 / Antithrombin-III Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

SERPINC1 / Antithrombin-III (33-464, His-tag)

SERPINC1 / Antithrombin-III Human Purified > 85 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

SERPINC1 / Antithrombin-III (33-464, His-tag)

SERPINC1 / Antithrombin-III Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

SERPINC1 / Antithrombin-III

SERPINC1 / Antithrombin-III Human Purified Plasma
0.1 mg / €220.00
  Acris Antibodies GmbH

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SERPINC1 (mGFP-tagged) - Human serpin peptidase inhibitor, clade C (antithrombin), member 1 (SERPINC1), 200 uL, >10^7 TU/mL

Lenti ORF particles, SERPINC1 (mGFP-tagged) - Human serpin peptidase inhibitor, clade C (antithrombin), member 1 (SERPINC1), 200 uL, >10^7 TU/mL  
200 µl / €1,070.00
  OriGene Technologies, Inc.

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