SERPINC1 / Antithrombin-III antibody

Principal name

SERPINC1 / Antithrombin-III antibody

Alternative names for SERPINC1 / Antithrombin-III antibody

AT3, Serpin C1, ATIII

SwissProt ID

P01008 (Human), P32261 (Mouse), P32262 (Sheep), P41361 (Bovin), P81050 (Mesau), Q03352 (Chick), Q5M7T5 (Rat)

Gene ID

462 (SERPINC1), 11905 (Serpinc1), 304917, 831462 (GRF5)

Available reactivities

Hu (Human), Mky (Monkey), Can (Canine), Fe (Feline), Ms (Mouse), Rt (Rat), Eq (Equine), Bov (Bovine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Sh (Sheep), Ze (Zebrafish)

Available hosts

Mouse, Sheep, Rabbit, Goat, Rat

Available applications

Enzyme Immunoassay (E), Functional assay (FN), Western blot / Immunoblot (WB), Immunodiffusion (ID), Dot blot (Dot), Paraffin Sections (P), Radioimmunoassay (R), ELISA (detection) (E(detection)), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of SERPINC1 / Antithrombin-III antibody

Antithrombin II is a single polypeptide chain glycoprotein (MW 61,000) with a high degree of homology with the alpha-1 antitrypsin. It is a circulating natural anticoagulant acting as a proteinase inhibitor. It is synthesized in the liver and the vascular endothelial cells. In electrophoresis of plasma it migrates in the alpha-1 region and is consumed during coagulation in vivo. Antithrombin III inhibits the action of factors IXa, Xa, XIIa, thombin and kallikrein by forming a stable complex. Heparin acts as a cofactor which greatly increases its inhibitory activities.
Normal adult plasma contain an average of 0.15 mg antithrombin III per ml. This can vary from 75 to 128%. A partial deficiency in antithrombin III activity in the plasma (less than 50%) will result in an increased tendency to recurrent thrombo-enbolism. Several types of congenital deficiency have been reported. Most common type 1 deficiency patients have reduced antithrombin III antigen and activity levels. Heterozygotes have levels of 25 to 50% of normal values.

General readings

(1) Ishiguro K. et al. (2000) J Clin Invest. 106, 873-8.
(2) Vossenaar E.R. et al (2003) Bioessays. 25:1106-
(3) Chang, X. et al. (2005) Rheumatology. 44, 293-298.
(4) Pike, R. N. et al. (1997) J. Biol. Chem. 272, 19652-196655.
(5) Chang, X. et al. (2009) BMC Cancer. 9:40.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SERPINC1 / Antithrombin-III (C-term) antibody

Western blot analysis of SERPINC1 Antibody (C-term) (Cat. #TA324863) in mouse liver tissue lysates (35ug/lane). SERPINC1 (arrow) was detected using the purified Pab. Rabbit Hu, Ms WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

SERPINC1 / Antithrombin-III antibody

Predicted cell location: Cytoplasm, Nucleus. Positive control: Human thyroid and lung cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using SERPINC1 antibody at dilution 1/15, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

SERPINC1 / Antithrombin-III antibody

Predicted cell location: Cytoplasm. Positive control: Human ovarian cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human ovarian cancer tissue using SERPINC1 antibody at dilution 1/30, on the right is treated with the fusion protein. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

SERPINC1 / Antithrombin-III antibody

Western blot analysis of extracts of various cell lines, using SERPINC1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

SERPINC1 / Antithrombin-III antibody

WB Suggested Anti-SERPINC1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: PANC1 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Sh, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

SERPINC1 / Antithrombin-III antibody

WB Suggested Anti-Serpinc1 Antibody; Titration: 1.0 ug/ml; Positive Control: Mouse Small Intestine Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

SERPINC1 / Antithrombin-III antibody

Western blot analysis of extracts (10ug) from 10 Human tissue by using anti-SERPINC1 monoclonal antibody at 1:500 (1: Testis; 2: Omentum; 3: Uterus; 4: Breast; 5: Brain; 6: Liver; 7: Ovary; 8: Thyroid gland; 9: colon;10: spleen). Mouse IgG2b OTI8D5 Purified Hu F, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

SERPINC1 / Antithrombin-III antibody

Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 n.a Purified Hu E, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

SERPINC1 / Antithrombin-III antibody

SERPINC1 / Antithrombin-III Sheep Purified Can, Eq, Fe, Hu, Ms, Rt ID, P
1 ml / €360.00
  Acris Antibodies GmbH

SERPINC1 / Antithrombin-III antibody

SERPINC1 / Antithrombin-III Goat Serum Hu C, E, ID
1 ml / €250.00
  Acris Antibodies GmbH

SERPINC1 / Antithrombin-III antibody

SERPINC1 / Antithrombin-III Mouse IgG1 BDI205 Purified Hu, Mky E, FN, WB
0.5 mg / €710.00
  Acris Antibodies GmbH

SERPINC1 / Antithrombin-III antibody

SERPINC1 MaxPab polyclonal antibody. Western Blot analysis of SERPINC1 expression in human kidney. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

SERPINC1 / Antithrombin-III antibody

Western Blot analysis of SERPINC1 expression in transfected 293T cell line (H00000462-T02) by SERPINC1 MaxPab polyclonal antibody.

Lane 1: SERPINC1 transfected lysate(29.10 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

SERPINC1 / Antithrombin-III antibody

SERPINC1 / Antithrombin-III Mouse IgG2b 3G9 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SERPINC1 / Antithrombin-III antibody

SERPINC1 monoclonal antibody (M02), clone 2B12. Western Blot analysis of SERPINC1 expression in human kidney. Mouse IgG2b 2B12 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SERPINC1 / Antithrombin-III antibody

SERPINC1 / Antithrombin-III Mouse IgG2b 2B12 Ascites Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

SERPINC1 / Antithrombin-III antibody

Immunoblot analysis of human plasma protein. Lane 1 : Antithrombin III isolated from human plasma. Lane 2 : Human plasma. Mouse IgG1 8C12 Hu E, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

SERPINC1 / Antithrombin-III antibody

SERPINC1 / Antithrombin-III Mouse Rt E, R, WB
0.4 mg / €390.00
  Abnova Taiwan Corp.

SERPINC1 / Antithrombin-III antibody

SERPINC1 / Antithrombin-III Sheep Ms E, WB
1 mg / €390.00
  Abnova Taiwan Corp.

SERPINC1 / Antithrombin-III antibody

SERPINC1 / Antithrombin-III Rabbit Ms E, R, WB
0.4 mg / €390.00
  Abnova Taiwan Corp.

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