SERPIND1 antibody

Principal name

SERPIND1 antibody

Alternative names for SERPIND1 antibody

Serpin D1, Heparin cofactor 2, HCF2, HC-II, HLS2, Protease inhibitor leuserpin-2

SwissProt ID

P05546 (Human), P47776 (Rabit), P49182 (Mouse), Q64268 (Rat)

Gene ID

3053 (SERPIND1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Sheep

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Immunodiffusion (ID)

Background of SERPIND1 antibody

The herpes simplex virus (HSV) infection is initiated by VP16, a viral transcription factor that activates the viral immediate-early (IE) genes.The anticoagulant action of heparin is dependent on plasma components termed heparin cofactors. The first of these to be well characterized was antithrombin III. Heparin Cofactor II is antigenically distinct from AT III. Heparin Cofactor II is normal in patients with AT III deficiency and is low in patients with disseminated intravascular coagulation. It is expressed predominantly in liver. Its function is: thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, Heparin Cofactor II becomes the predominant thrombin inhibitor in place of antithrombin III (AT III). Also inhibits chymotrypsin, but in a glycosaminoglycan independent manner and peptides at the N terminal of Heparin Cofactor II have chemotactic activity for both monocytes and neutrophils. The N terminal acidic repeat region mediates, in part, the glycosaminoglycan accelerated thrombin inhibition. Defects in SERPIND1 are the cause of Heparin Cofactor II deficiency. Heparin Cofactor II deficiency is an important risk factor for hereditary thrombophilia, a multifactorial trait characterized by recurrent thrombosis and abnormal platelet aggregation in response to various agents. Heparin Cofactor II deficiency is inherited as an autosomal dominant disorder, in which affected individuals are prone to develop serious spontaneous thrombosis.

General readings

van Deerlin V.M.D., Tollefsen D.M. (1991) J. Biol. Chem. 266:20223-20231.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SERPIND1 antibody

Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using Heparin Cofactor II antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

SERPIND1 antibody

Western blot analysis of extracts of various cell lines, using SERPIND1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

SERPIND1 antibody

WB Suggested Anti-SERPIND1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: THP-1 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

SERPIND1 antibody

SERPIND1 Rabbit Serum Hu ID, IP
1 ml / €360.00
  Acris Antibodies GmbH

SERPIND1 antibody

Western Blot analysis of SERPIND1 expression in transfected 293T cell line (H00003053-T01) by SERPIND1 MaxPab polyclonal antibody.

Lane 1: SERPIND1 transfected lysate(54.89 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

SERPIND1 antibody

Western Blot analysis of SERPIND1 expression in transfected 293T cell line (H00003053-T01) by SERPIND1 MaxPab polyclonal antibody.

Lane 1: SERPIND1 transfected lysate(54.89 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

SERPIND1 antibody

SERPIND1 Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

SERPIND1 antibody

Western Blot analysis of SERPIND1 expression in transfected 293T cell line (H00003053-T01) by SERPIND1 MaxPab polyclonal antibody.

Lane 1: SERPIND1 transfected lysate(57.00 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

SERPIND1 antibody

Immunoblot analysis of human plasma. Lane 1 : Heparin cofactor II isolated from human plasma. Lane 2 : Human plasma. Mouse IgG2b 74E5 Hu C, E, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

SERPIND1 antibody

Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using Heparin Cofactor II Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
50 µg / €205.00
  Assay Biotech

SERPIND1 antibody

Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using Heparin Cofactor II Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
0.1 mg / €310.00
  Assay Biotech

SERPIND1 antibody

Human THP-1; WB Suggested Anti-SERPIND1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: THP-1 cell lysate; SERPIND1 antibody - middle region (ARP41368_P050) in Human THP-1 cells using Western Blot Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

SERPIND1 antibody

SERPIND1 Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, P
0.1 mg / €360.00
  Novus Biologicals Inc.

SERPIND1 antibody

SERPIND1 Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, P
50 µg / €290.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SERPIND1 (58-499, His-tag)

SERPIND1 Human Purified > 85 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

SERPIND1 (58-499, His-tag)

SERPIND1 Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

SERPIND1

SERPIND1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

SERPIND1

SERPIND1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Antibody Pairs

Catalog No.    

SERPIND1 (Human) IP-WB Antibody Pair

SERPIND1 (Human) IP-WB Antibody Pair  
1 set / €710.00
  Abnova Taiwan Corp.

SERPIND1 (Human) Matched Antibody Pair

SERPIND1 (Human) Matched Antibody Pair  
1 set / €710.00
  Abnova Taiwan Corp.

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