SERPINE1 / PAI1 antibody

Principal name

SERPINE1 / PAI1 antibody

Alternative names for SERPINE1 / PAI1 antibody

Serpin E1, PLANH1, Plasminogen Activator Inhibitor 1, PAI-1, PAI, Endothelial plasminogen activator inhibitor

SwissProt ID

P05121 (Human), P13909 (Bovin), P20961 (Rat), P22777 (Mouse), P50449 (Musvi), P79335 (Pig)

Gene ID

5054 (SERPINE1), 24617 (Serpine1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Eq (Equine), Marmoset, Mky (Monkey), Gorilla, Bov (Bovine), Por (Porcine), Chk (Chicken), Dros (Drosophila), Ze (Zebrafish), African clawed frog, Rb (Rabbit), Sh (Sheep), GP (Guinea Pig), Gt (Goat)

Available hosts

Rabbit, Mouse, Goat, Sheep

Available applications

Enzyme Immunoassay (E), Immunoprecipitation (IP), Paraffin Sections (P), Western blot / Immunoblot (WB), Functional assay (FN), Frozen Sections (C), Radioimmunoassay (R), ELISA (detection) (E(detection)), Flow Cytometry (F), Neutralisation (NEUT)

Background of SERPINE1 / PAI1 antibody

Plasminogen activator inhibitor-1 (PAI-1) is the primary inhibitor of plasminogen activators in plasma, rapidly inactivating both tissue plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA). PAI-1 is a single-chain glycoprotein with a molecular weight of 47 kilodaltons. During fibrinolysis, tissue plasminogen activator (tPA) converts the inactive protein plasminogen into plasmin which plays a critical role in fibrinolysis by degrading fibrin and providing localized protease activity in a number of physiological functions. PAI-1 is synthesized in the liver and by endothelial cells, and its synthesis is regulated by several physiologic mediators, including endotoxin, interleukin-1, fibroblast growth factor-2, and lipids. Plasminogen activator inhibitor-1 is an important inhibitor of the fibrinolytic system, so elevated levels could suppress fibrinolysis and result in an increased risk of thrombosis. Increased PAI-1 levels have been shown to be associated with a number of atherosclerotic risk factors, PAI-1 has been shown to act as a prothrombic factor in both arterial and venous thromboembolic disorders. Increased levels of PAI-1 are associated with an increased incidence of acute coronary syndrome. PAI-1 levels are also increased in patients with chronic and acute coronary artery disease (CAD) and in patients who suffer restenosis after coronary angioplasty.Plasminogen activator inhibitor-1 (PAI-1) is the primary inhibitor of plasminogen activators in plasma, rapidly inactivating both tissue plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA). PAI-1 is a single-chain glycoprotein with a molecular weight of 47 kilodaltons. During fibrinolysis, tissue plasminogen activator (tPA) converts the inactive protein plasminogen into plasmin which plays a critical role in fibrinolysis by degrading fibrin and providing localized protease activity in a number of physiological functions. PAI-1 is synthesized in the liver and by endothelial cells, and its synthesis is regulated by several physiologic mediators, including endotoxin, interleukin-1, fibroblast growth factor-2, and lipids. Plasminogen activator inhibitor-1 is an important inhibitor of the fibrinolytic system, so elevated levels could suppress fibrinolysis and result in an increased risk of thrombosis. Increased PAI-1 levels have been shown to be associated with a number of atherosclerotic risk factors, PAI-1 has been shown to act as a prothrombic factor in both arterial and venous thromboembolic disorders. Increased levels of PAI-1 are associated with an increased incidence of acute coronary syndrome. PAI-1 levels are also increased in patients with chronic and acute coronary artery disease (CAD) and in patients who suffer restenosis after coronary angioplasty.

General readings

1. Keates AC, Tummala S, Peek RM Jr, Csizmadia E, Kunzli B, Becker K, Correa P, Romero-Gallo J, Piazuelo MB, Sheth S, Kelly CP, Robson SC, Keates S. Helicobacter pylori infection stimulates plasminogen activator inhibitor 1 production by gastric epithelial cells. Infect Immun. 2008 Sep;76(9):3992-9.
PMID: 18519558

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SERPINE1 / PAI1 antibody

TA303014 (0.1µg/ml) staining of Human Liver lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SERPINE1 / PAI1 antibody

Immunohistochemical analysis of paraffin-embedded lung cancer tissues using SERPINE1 Antibody Cat.-No AM33172PU-N (Clone 1D5) with DAB staining. Mouse IgG1 1D5 Purified Hu E, F, P, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

SERPINE1 / PAI1 antibody

TA303014 (0.1µg/ml) staining of Human Liver lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu E, P, WB
20 µg / €200.00
  Acris Antibodies GmbH

SERPINE1 / PAI1 antibody

Predicted cell location: Cytoplasm. Positive control: Human breast and colon cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human breast cancer tissue using SERPINE1 antibody at dilution 1/20, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

SERPINE1 / PAI1 (Center) antibody

Western blot analysis of SERPINE1 (arrow) using rabbit polyclonal SERPINE1 Antibody (Center) (Cat. #TA324506). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the SERPINE1 gene. Rabbit Ig Aff - Purified Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

SERPINE1 / PAI1 antibody

This antibody stained formalin-fixed, paraffin-embedded sections of human breast invasive ductal carcinoma.  The recommended concentration is 62.5 ng/ml with an overnight incubation at 4C.  An HRP-labeled polymer detection system was used with a DAB chromogen.  Heat induced antigen retrieval with a pH 6.0 sodium citrate buffer is recommended.  Optimal concentrations and conditions may vary.    *Additional Immunostaining data available. Please contact Tech Support for information. Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SERPINE1 / PAI1 antibody

Western Blot: PAI1/Serpine1 Antibody [TA336741] - Extracts from Jurkat cells. Rabbit Purified Hu, Ms, Rt C, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SERPINE1 / PAI1 antibody

WB Suggested Anti-SERPINE1 Antibody Titration: 0.2-1 ug/ml; Positive Control: Transfected 293T Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

SERPINE1 / PAI1 antibody

WB Suggested Anti-SERPINE1 Antibody Titration: 0.2-1 ug/ml; Positive Control: Transfected 293T Rabbit IgG Purified Bov, Can, Eq, GP, Gt, Hu, Ms, Por, Rb, Rt, Sh, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

SERPINE1 / PAI1 antibody

SERPINE1 / PAI1 Mouse IgG 3E529 Purified Hu E
0.2 mg / €460.00
  Acris Antibodies GmbH

SERPINE1 / PAI1 antibody

SERPINE1 / PAI1 Mouse IgG1 MA-124K1 Purified Ms, Rt E, FN
0.1 mg / €340.00
  Acris Antibodies GmbH

SERPINE1 / PAI1 antibody

SERPINE1 / PAI1 Mouse IgG1 MA-56A7C10 Purified Hu, Por E, FN
0.1 mg / €340.00
  Acris Antibodies GmbH

SERPINE1 / PAI1 antibody

SERPINE1 / PAI1 Mouse IgG1 MA-55F4C12 Purified Hu, Ms, Rt E, FN
0.1 mg / €340.00
  Acris Antibodies GmbH

SERPINE1 / PAI1 antibody

SERPINE1 / PAI1 Mouse IgG1 MA-33H1F7 Purified Hu, Ms, Rt E, FN, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

SERPINE1 / PAI1 antibody

SERPINE1 / PAI1 Mouse IgG1 MA-33H1F7 Liquid Hu, Ms, Rb, Rt C, E, FN, WB
0.1 mg / €500.00
  Acris Antibodies GmbH

SERPINE1 / PAI1 antibody

SERPINE1 / PAI1 Rabbit Purified Hu C, E, WB
0.2 mg / €460.00
  Acris Antibodies GmbH

SERPINE1 / PAI1 antibody

SERPINE1 / PAI1 Goat Purified Hu C, E, P, R
0.1 mg / €320.00
  Acris Antibodies GmbH

SERPINE1 / PAI1 antibody

SERPINE1 / PAI1 Goat Purified Hu C, E, P, R
10 µg / €130.00
  Acris Antibodies GmbH

SERPINE1 / PAI1 antibody

SERPINE1 / PAI1 Goat Serum Hu C, E, P, R
0.1 ml / €220.00
  Acris Antibodies GmbH

SERPINE1 / PAI1 antibody

SERPINE1 / PAI1 Goat Serum Hu C, E, P, R
20 µl / €120.00
  Acris Antibodies GmbH

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