SERPINE1 / PAI1 antibody

Principal name

SERPINE1 / PAI1 antibody

Alternative names for SERPINE1 / PAI1 antibody

Serpin E1, PLANH1, Plasminogen Activator Inhibitor 1, PAI-1, PAI, Endothelial plasminogen activator inhibitor

SwissProt ID

P05121 (Human), P13909 (Bovin), P20961 (Rat), P22777 (Mouse), P50449 (Musvi), P79335 (Pig)

Gene ID

24617 (Serpine1), 5054 (SERPINE1)

Available reactivities

Rt (Rat), Hu (Human), Ms (Mouse), Bov (Bovine), Por (Porcine), Can (Canine), Chk (Chicken), Dros (Drosophila), Ze (Zebrafish), African clawed frog, Rb (Rabbit), Mky (Monkey), Prim (Primate), Eq (Equine), Sh (Sheep), GP (Guinea Pig), Gt (Goat)

Available hosts

Rabbit, Mouse, Goat, Sheep

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Frozen Sections (C), Radioimmunoassay (R), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Functional assay (FN), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of SERPINE1 / PAI1 antibody

Plasminogen activator inhibitor type-1 (PAI-1), a member of the serine protease inhibitor (serpin) superfamily is an important protein in the regulation of fibrinolysis. PAI-1 is unique among the serpins because of its functional and conformational flexibility. PAI-1 is the most important physiological inhibitor of both tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA). Increased PAI-1 levels are associated with thrombotic events and is an established risk factor for cardiovascular diseases. The active conformation PAI-1 inhibits its target proteinases by the formation of a stable, inactive complex. Although PAI-1 is synthesized as an active molecule, it converts spontaneously to an inactive, latent form that can be partially reactivated by denaturing agents. In addition, a third conformation reacting as a non-inhibitory substrate towards various target proteinases has been identified.
The residues Glu242, Lys243 and Glu244, located in the loop connecting s3B with hG (designated loop 2) and the residues Glu350, Asp355 and Arg356, located at the distal hinge of the reactive site loop, form the major site of interaction for the monoclonal antibody MA-56A7C10. This is clearly a conformational epitope comprising residues clustered together in the three dimensional structure.

General readings

1. Keates AC, Tummala S, Peek RM Jr, Csizmadia E, Kunzli B, Becker K, Correa P, Romero-Gallo J, Piazuelo MB, Sheth S, Kelly CP, Robson SC, Keates S. Helicobacter pylori infection stimulates plasminogen activator inhibitor 1 production by gastric epithelial cells. Infect Immun. 2008 Sep;76(9):3992-9.
PMID: 18519558

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SERPINE1 / PAI1 antibody

  Goat Polyclonal Antibody against SERPINE1  
TA303014 (0.1µg/ml) staining of Human Liver lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SERPINE1 / PAI1 antibody

Immunohistochemical analysis of paraffin-embedded lung cancer tissues using SERPINE1 Antibody Cat.-No AM33172PU-N (Clone 1D5) with DAB staining. Mouse IgG1 1D5 Purified Hu E, F, P, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

SERPINE1 / PAI1 antibody

  Anti-SERPINE1 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human breast and colon cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human breast cancer tissue using SERPINE1 antibody at dilution 1/20, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

SERPINE1 / PAI1 (Center) antibody

  Rabbit polyclonal SERPINE1 Antibody (Center)  
Western blot analysis of SERPINE1 (arrow) using rabbit polyclonal SERPINE1 Antibody (Center) (Cat. #TA324506). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the SERPINE1 gene. Rabbit Ig Aff - Purified Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

SERPINE1 / PAI1 antibody

  Anti-Human PAI-1 Rabbit Polyclonal Antibody  
This antibody stained formalin-fixed, paraffin-embedded sections of human breast invasive ductal carcinoma.  The recommended concentration is 62.5 ng/ml with an overnight incubation at 4C.  An HRP-labeled polymer detection system was used with a DAB chromogen.  Heat induced antigen retrieval with a pH 6.0 sodium citrate buffer is recommended.  Optimal concentrations and conditions may vary.    *Additional Immunostaining data available. Please contact Tech Support for information. Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SERPINE1 / PAI1 antibody

  Rabbit Polyclonal Serpin E1/PAI-1 Antibody  
Western Blot: PAI1/Serpine1 Antibody [TA336741] - Extracts from Jurkat cells. Rabbit Purified Hu, Ms, Rt C, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SERPINE1 / PAI1 antibody

  Rabbit Polyclonal Anti-SERPINE1 Antibody  
WB Suggested Anti-SERPINE1 Antibody Titration: 0.2-1 ug/ml; Positive Control: Transfected 293T Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

SERPINE1 / PAI1 antibody

  Rabbit Polyclonal Anti-SERPINE1 Antibody  
WB Suggested Anti-SERPINE1 Antibody Titration: 0.2-1 ug/ml; Positive Control: Transfected 293T Rabbit IgG Purified Bov, Can, Eq, GP, Gt, Hu, Ms, Por, Rb, Rt, Sh, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

SERPINE1 / PAI1 antibody

SERPINE1 / PAI1 Mouse IgG 3E529 Purified Hu E
0.2 mg / €490.00
  Acris Antibodies GmbH

SERPINE1 / PAI1 antibody

SERPINE1 / PAI1 Mouse IgG1 MA-124K1 Purified Ms, Rt E, FN
0.1 mg / €350.00
  Acris Antibodies GmbH

SERPINE1 / PAI1 antibody

SERPINE1 / PAI1 Mouse IgG1 MA-56A7C10 Purified Hu, Por E, FN
0.1 mg / €350.00
  Acris Antibodies GmbH

SERPINE1 / PAI1 antibody

SERPINE1 / PAI1 Mouse IgG1 MA-55F4C12 Purified Hu, Ms, Rt E, FN
0.1 mg / €350.00
  Acris Antibodies GmbH

SERPINE1 / PAI1 antibody

SERPINE1 / PAI1 Mouse IgG1 MA-33H1F7 Purified Hu, Ms, Rt E, FN, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

SERPINE1 / PAI1 antibody

SERPINE1 / PAI1 Mouse IgG1 MA-33H1F7 Liquid Hu, Ms, Rb, Rt C, E, FN, WB
0.1 mg / €520.00
  Acris Antibodies GmbH

SERPINE1 / PAI1 antibody

SERPINE1 / PAI1 Rabbit Purified Hu C, E, WB
0.2 mg / €490.00
  Acris Antibodies GmbH

SERPINE1 / PAI1 antibody

SERPINE1 / PAI1 Goat Purified Hu C, E, P, R
0.1 mg / €320.00
  Acris Antibodies GmbH

SERPINE1 / PAI1 antibody

SERPINE1 / PAI1 Goat Purified Hu C, E, P, R
10 µg / €130.00
  Acris Antibodies GmbH

SERPINE1 / PAI1 antibody

SERPINE1 / PAI1 Goat Serum Hu C, E, P, R
0.1 ml / €220.00
  Acris Antibodies GmbH

SERPINE1 / PAI1 antibody

SERPINE1 / PAI1 Goat Serum Hu C, E, P, R
20 µl / €120.00
  Acris Antibodies GmbH

SERPINE1 / PAI1 antibody

Immunohistochemistry analyzes of PAI-1 Antibody (Cat.-No AP20625PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

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