SERPINF1 / PEDF antibody

Principal name

SERPINF1 / PEDF antibody

Alternative names for SERPINF1 / PEDF antibody

Pigment epithelium-derived factor, Serpin-F1, EPC-1

SwissProt ID

P36955 (Human), P97298 (Mouse), Q95121 (Bovin)

Gene ID

5176 (SERPINF1), 20317 (Serpinf1)

Available reactivities

Hu (Human), Ms (Mouse), Rb (Rabbit), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine)

Available hosts

Mouse, Rabbit, Goat, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Frozen Sections (C)

Background of SERPINF1 / PEDF antibody

PEDF is a non-inhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. It is a 50 kDa glycoprotein produced and secreted in many tissues throughout the body. A major component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. In addition, PEDF is able to inhibit the activity of angiogenic factors such as VEGF and FGF-2. The neuroprotective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins. The recent identification of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity (1) should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member. The unique range of PEDF activities implicate it as a potential therapeutic agent for the treatment of vasculature related neurodegenerative diseases such as age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR). PEDF also has the potential to be useful in the treatment of various angiogenesis-related diseases including a number of cancers.

General readings

Baba H. et al (2005) Arteriosler Thromb Vasc Biol. 25, 1938-1944
Filleur S. et al (2005) Cancer Res. 65, 5144-5152
Hattenbach LO. et al (2004) Ophthalmic Res. 37, 341-346

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SERPINF1 / PEDF antibody

Predicted band size: 46kDa. Positive control: K562 cell lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lysate:40 ug Primary antibody: 1/200 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/8000 dilution Exposure time: 2 minutes) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SERPINF1 / PEDF antibody

Predicted band size: 46 kDa . Positive control: 293T cell lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/150 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SERPINF1 / PEDF antibody

Western blot analysis of extracts of human liver cell lines, using SERPINF1 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SERPINF1 / PEDF antibody

WB Suggested Anti-SERPINF1 Antibody Titration: 0.2-1 ug/ml; Positive Control: Human Placenta Rabbit IgG Purified Hu P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

SERPINF1 / PEDF antibody

TA334193 (0.3µg/ml) staining of Human Albumin-depleted Plasma (A) and Serum (B) lysates (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Por E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SERPINF1 / PEDF antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SERPINF1 (RC204186, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SERPINF1. Mouse IgG2a OTI1F7 Purified Hu WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

SERPINF1 / PEDF (N-term) antibody

Western blot analysis of SERPINF1 Antibody (N-term) (AP17737PU-N) in 293 cell line lysates (35ug/lane). SERPINF1 (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

SERPINF1 / PEDF antibody

SERPINF1 antibody (Cat.-No SM6032) staining of Formalin-Fixed, Paraffin-Embedded Human placenta at 10 µg/ml followed by biotinylated anti-Mouse IgG secondary antibody, Alkaline Phosphatase-Streptavidin and chromogen. Mouse IgG1 1C4 Purified Hu E, P, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

SERPINF1 / PEDF antibody

SERPINF1 antibody (Cat.-No SM6032) staining of Formalin-Fixed, Paraffin-Embedded Human placenta at 10 µg/ml followed by biotinylated anti-Mouse IgG secondary antibody, Alkaline Phosphatase-Streptavidin and chromogen. Mouse IgG1 1C4 Purified Hu, Rb E, P, WB
50 µl / €230.00
  Acris Antibodies GmbH

SERPINF1 / PEDF antibody

Western Blot analysis of SERPINF1 expression in transfected 293T cell line (H00005176-T01) by SERPINF1 MaxPab polyclonal antibody.

Lane 1: SERPINF1 transfected lysate(46.30 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

SERPINF1 / PEDF antibody

Western blot analysis of A-549 cell lysate was resolved by SDS - PAGE , transferred to PVDF membrane and probed with SERPINF1 monoclonal antibody , clone 1C4 ( 1 : 1000 ) ( Cat # MAB1077 ) . Protein was visualized using a goat anti - mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG1 1C4 Hu E, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

SERPINF1 / PEDF antibody

Western blot analysis of extract from retinal pigment epithelium, using SERPINF1 monoclonal antibody, clone 14K ( Cat # MAB1712 ) . Mouse IgG1 14K Hu WB
50 µg / €740.00
  Abnova Taiwan Corp.

SERPINF1 / PEDF antibody

SERPINF1 / PEDF Mouse IgG1 710-1E-94 Hu E, WB
0.2 mg / €900.00
  Abnova Taiwan Corp.

SERPINF1 / PEDF antibody

SERPINF1 / PEDF Rabbit Hu E, WB
1 mg / €730.00
  Abnova Taiwan Corp.

SERPINF1 / PEDF antibody

SERPINF1 / PEDF Mouse IgG1 14K Purified Hu WB
50 µg / €700.00
  Funakoshi Co., Ltd.

SERPINF1 / PEDF antibody

Western Blot: PEDF Antibody [NB600-1493] - Y79 cell lysate was probed with 1.0µg/ml of Anti-PEDF. Rabbit IgG Purified Hu, Ms WB
0.1 mg / €400.00
  Novus Biologicals Inc.

SERPINF1 / PEDF antibody

SERPINF1 / PEDF Mouse IgG1 1C4 Purified Hu E, WB
0.1 ml / €380.00
  Novus Biologicals Inc.

SERPINF1 / PEDF antibody

SERPINF1 / PEDF Rabbit Aff - Purified Hu, Ms, Rt P
0.1 mg / €420.00
  Novus Biologicals Inc.

SERPINF1 / PEDF antibody

Immunohistochemistry-Paraffin: PEDF Antibody [NBP1-83972] - Immunohistochemical staining of human breast shows cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SERPINF1 / PEDF

SERPINF1 / PEDF Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

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