Sestrin-1 (SESN1) antibody

Principal name

Sestrin-1 (SESN1) antibody

Alternative names for Sestrin-1 (SESN1) antibody

Sestrin 1, SEST1, PA26

SwissProt ID

P58003 (Xenla), P58006 (Mouse), Q9Y6P5 (Human)

Gene ID

27244 (SESN1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), Por (Porcine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP), Flow Cytometry (F), Neutralisation (NEUT)

Background of Sestrin-1 (SESN1) antibody

Sestrin 1 (SESN1), located on rat chromosome 20q13, belongs to the sestrin family of proteins. These proteins are cystein sulfinyl reductases and they modulate peroxide signaling and antioxidant defense (1). This family of proteins is only present in multicellular organisms ranging from nematodes to mammals. These proteins selectively reduce or repair hyperoxidized forms of typical 2-Cys peroxiredoxins within eukaryotes (2). Peroxiredoxins are the enzymes that metabolize peroxides. Expression of these proteins is regulated by p53, a tumor suppressor protein (3). Sestrin 1 is implicated in the inhibition of cell growth. It has been reported that Sestrin 1 activates AMP-responsive protein kinase (AMPK) and targets it to phosphorylate TSC2, a tumor suppressor. Phosphorylation of TSC2 stimulates its GAP activity which inhibits the activity of mTOR, a positive regulator of cell growth, thus leading to inhibition of cell proliferation and growth (4).
Inhibition of mRNAs from sestrin 1 and 3 genes has been shown to substantially increase intracellular ROS levels. This increase in ROS is linked to Ras-induced mutagenesis which is one of the most common events in cancer (5). Sestrin 1 was also identified as a candidate gene for heterotaxia in humans (6). Recent studies have identified that AMPK is an essential mediator of tumor suppressor LKB1 and is suppressed in cancer cells (7). Since activity of AMPK is regulated by sestrin 1, this protein could be a promising target for cancer treatment and therapy. Sestrin 1 is approximately a 66.1kDa protein in humans (551 amino acids) and 55.4kDa protein in mouse and rat (462 amino acids).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Sestrin-1 (SESN1) antibody

Western blot analysis of extracts from rat muscle cells, using SESN1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Sestrin-1 (SESN1) antibody

Host: Rabbit; Target Name: SESN1; Sample Tissue: THP-1 Whole cell lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Sestrin-1 (SESN1) Control Peptide

Sestrin-1 (SESN1) Ms
0.1 mg / €250.00
  Acris Antibodies GmbH

Sestrin-1 (SESN1) (N-term) antibody

Western Blot of Sestrin-1 antibody (Cat#AP09869PU-N) at 1/500 dilution. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Sestrin-1 (SESN1) antibody

SESN1 polyclonal antibody (A01), Lot # ABNOVA060616QCS1 Western Blot analysis of SESN1 expression in Hela NE ( Cat # L013V3 ). Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Sestrin-1 (SESN1) antibody

Immunofluorescence of purified MaxPab antibody to SESN1 on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

Sestrin-1 (SESN1) antibody

Sestrin-1 (SESN1) Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

Sestrin-1 (SESN1) antibody

Western Blot analysis of SESN1 expression in transfected 293T cell line (H00027244-T02) by SESN1 MaxPab polyclonal antibody.

Lane 1: SESN1 transfected lysate(63.80 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Sestrin-1 (SESN1) antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using SESN1 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

Sestrin-1 (SESN1) antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using SESN1 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €310.00
  Assay Biotech

Sestrin-1 (SESN1) antibody

Sestrin-1 (SESN1) Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €410.00
  Novus Biologicals Inc.

Sestrin-1 (SESN1) antibody

Western Blot: SESN1 Peptide [NBP1-44993PEP] - WB of SESN1 at 1:500 dilution in diluObuffer
was probed with PCSESN1 sample. Apparent MW of SESN1 is 89kDa Aff - Purified E, NEUT, WB
0.25 mg / €340.00
  Novus Biologicals Inc.

Sestrin-1 (SESN1) antibody

Western Blot: SESN1 Antibody [FITC] [NBP1-44994] - WB of SESN1 at 1:500 dilution in diluObuffer
was probed with PCSESN1 sample. Apparent MW of SESN1 is 89kDa Rabbit IgG FITC Hu, Ms, Rt E, WB
0.1 mg / €540.00
  Novus Biologicals Inc.

Sestrin-1 (SESN1) antibody

Sestrin-1 (SESN1) Rabbit IgG Aff - Purified Hu, Ms E, P, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

Sestrin-1 (SESN1) antibody

Sestrin-1 (SESN1) Rabbit IgG Aff - Purified Hu, Ms E, P, WB
50 µg / €290.00
  Novus Biologicals Inc.

Sestrin-1 (SESN1) antibody

Western Blot: SESN1 Antibody (EPR1930(2)) [NBP1-96045] - Sestrin-1. Rabbit EPR1930(2) Purified Hu, Ms, Rt F, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Sestrin-1 (SESN1)

Sestrin-1 (SESN1) Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Sestrin-1 (SESN1)

Sestrin-1 (SESN1) Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Sestrin-1 (SESN1)

Western Blot: SESN1 Protein [NBP1-44997] - WB of SESN1 at 1:500 dilution in diluObuffer
was probed with PCSESN1 sample. Apparent MW of SESN1 is 89kDa Human Aff - Purified
0.15 ml / €360.00
  Novus Biologicals Inc.

Antibody Pairs

Catalog No.    

SESN1 (Human) IP-WB Antibody Pair

SESN1 (Human) IP-WB Antibody Pair  
1 set / €710.00
  Abnova Taiwan Corp.

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