Sestrin-3 (SESN3) antibody

Principal name

Sestrin-3 (SESN3) antibody

Alternative names for Sestrin-3 (SESN3) antibody

SEST3

SwissProt ID

P58005 (Human), Q9CYP7 (Mouse)

Gene ID

143686 (SESN3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Neutralisation (NEUT)

Background of Sestrin-3 (SESN3) antibody

Sestrin 3(SESN3), located at human chromosome 11q21, belongs to the sestrin family of proteins. These proteins are cystein sulfinyl reductases and they modulate peroxide signaling and antioxidant defense (1). This family of proteins is only present in multicellular organisms ranging from nematodes to mammals. These proteins selectively reduce or repair hyperoxidized forms of typical 2-Cys peroxiredoxins within eukaryotes (2). Peroxiredoxins are the enzymes that metabolize peroxides. Expression of these proteins is regulated by p53, a tumor suppressor protein (3). Sestrin 3 was identified as a forkhead box O (FoxO) target gene with antioxidant activity (4). Recently it was reported that sestrin 3 may play an important role in AKT induced increase in ROS and it might be a promising target in selectively killing cancer cells containing high levels of AKT activity (5).
AKT is a protein kinase that is hyperactivated in cancer. This hyperactivity leads to an increase in intracellular ROS mainly by inhibiting the expression of ROS scavengers downstream of FoxO, such as sestrin 3 (4). This phenomenon was supported by the fact that AKT deficient cells contained high levels of sestrin 3 leading to low levels of ROS. Furthermore, downregulation of sestrin 3 restored ROS levels in these cells (5). Hyperactivation of AKT has been shown to promote uncontrolled cell growth and also protect cells from apoptosis (6). Inhibition of mRNAs from sestrin 3 as well as from sestrin 1 has also been shown to substantially increase intracellular ROS levels. This increase in ROS is linked to Ras-induced mutagenesis which is one of the most common events in cancer (7).
Sestrin 3 is approximately a 38.5kDa protein (480 amino acids) in human and 59kDa protein (492 amino acids) in rat and mouse.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Sestrin-3 (SESN3) antibody

SESN3 antibody detects SESN3 protein by Western blot analysis. A. 30 ug Rat2 whole cell lysate/extract. 7.5 % SDS-PAGE. SESN3 antibody (TA309053) dilution: 1:1000 Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Sestrin-3 (SESN3) Control Peptide

Sestrin-3 (SESN3)
0.1 mg / €250.00
  Acris Antibodies GmbH

Sestrin-3 (SESN3) (N-term) antibody

Western Blot of Sestrin-3 antibody (Cat#AP09871PU-N) at 1/500 dilution. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Sestrin-3 (SESN3) (Center) antibody

Immunohistochemistry analysis in Formalin Fixed, Paraffin Embedded Human pancreas tissue stained with antibody (Center Y335) Cat.-No AP53867PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of Sestrin-3 Antibody (Center Y335) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Sestrin-3 (SESN3) antibody

Immunofluorescence of purified MaxPab antibody to SESN3 on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

Sestrin-3 (SESN3) antibody

Western Blot analysis of SESN3 expression in transfected 293T cell line (H00143686-T02) by SESN3 MaxPab polyclonal antibody.

Lane 1: SESN3 transfected lysate(36.60 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Sestrin-3 (SESN3) antibody

SESN3 monoclonal antibody (M02), clone 2C9. Western Blot analysis of SESN3 expression in human pancreas. Mouse IgG1 2C9 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Sestrin-3 (SESN3) antibody

Western Blot: SESN3 Antibody [NBP1-31702] - (30 ug of whole cell lysate)  A: Hela  7.5% SDS PAGE diluted at 1:1000 Rabbit IgG Hu ICC/IF, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

Sestrin-3 (SESN3) antibody

Sestrin-3 (SESN3) Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €410.00
  Novus Biologicals Inc.

Sestrin-3 (SESN3) antibody

Western Blot: SESN3 Peptide [NBP1-44985PEP] - analysis at 1:500 dilution was probed with PC-SESN3 sample. MW of
SESN3 is approximately 59kDa. Aff - Purified Hu E, NEUT, WB
0.25 mg / €340.00
  Novus Biologicals Inc.

Sestrin-3 (SESN3) antibody

Western Blot: SESN3 Antibody [FITC] [NBP1-44986] - Western Blot of SESN3. SESN3 antibody (cat # SESN-301AP) at 1:500 dilution was probed with PC-SESN3 sample. MW of SESN3 is approximately 59kDa. Rabbit IgG FITC Hu, Ms, Rt E, WB
0.1 mg / €540.00
  Novus Biologicals Inc.

Sestrin-3 (SESN3) antibody

Immunohistochemistry-Paraffin: SESN3 Antibody [NBP1-82717] - Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine pancreas. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Sestrin-3 (SESN3)

Sestrin-3 (SESN3) Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

Sestrin-3 (SESN3)

Sestrin-3 (SESN3) Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Sestrin-3 (SESN3)

Sestrin-3 (SESN3) Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Sestrin-3 (SESN3)

Sestrin-3 (SESN3) Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Sestrin-3 (SESN3)

Western Blot: SESN3 Protein [NBP1-44988] - Western Blot of SESN3. SESN3 antibody (cat # NBP!-44985) at 1:500 dilution was probed with NBP1-44988 sample. MW of SESN3 is approximately 59kDa. Human Aff - Purified
0.15 ml / €360.00
  Novus Biologicals Inc.

Lysates

Catalog No.    

SESN3 293T Cell Transient Overexpression Lysate(Denatured)

SESN3 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

SESN3 overexpression lysate

SESN3 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

19 Item(s)

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