Sestrin-3 (SESN3) antibody

Principal name

Sestrin-3 (SESN3) antibody

Alternative names for Sestrin-3 (SESN3) antibody

SEST3

SwissProt ID

P58005 (Human), Q9CYP7 (Mouse)

Gene ID

143686 (SESN3), 75747 (Sesn3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of Sestrin-3 (SESN3) antibody

Sestrin 3(SESN3), located at human chromosome 11q21, belongs to the sestrin family of proteins. These proteins are cystein sulfinyl reductases and they modulate peroxide signaling and antioxidant defense (1). This family of proteins is only present in multicellular organisms ranging from nematodes to mammals. These proteins selectively reduce or repair hyperoxidized forms of typical 2-Cys peroxiredoxins within eukaryotes (2). Peroxiredoxins are the enzymes that metabolize peroxides. Expression of these proteins is regulated by p53, a tumor suppressor protein (3). Sestrin 3 was identified as a forkhead box O (FoxO) target gene with antioxidant activity (4). Recently it was reported that sestrin 3 may play an important role in AKT induced increase in ROS and it might be a promising target in selectively killing cancer cells containing high levels of AKT activity (5).
AKT is a protein kinase that is hyperactivated in cancer. This hyperactivity leads to an increase in intracellular ROS mainly by inhibiting the expression of ROS scavengers downstream of FoxO, such as sestrin 3 (4). This phenomenon was supported by the fact that AKT deficient cells contained high levels of sestrin 3 leading to low levels of ROS. Furthermore, downregulation of sestrin 3 restored ROS levels in these cells (5). Hyperactivation of AKT has been shown to promote uncontrolled cell growth and also protect cells from apoptosis (6). Inhibition of mRNAs from sestrin 3 as well as from sestrin 1 has also been shown to substantially increase intracellular ROS levels. This increase in ROS is linked to Ras-induced mutagenesis which is one of the most common events in cancer (7).
Sestrin 3 is approximately a 38.5kDa protein (480 amino acids) in human and 59kDa protein (492 amino acids) in rat and mouse.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Sestrin-3 (SESN3) antibody

  Rabbit polyclonal antibody to SESN3 (sestrin 3)  
SESN3 antibody detects SESN3 protein by Western blot analysis. A. 30 ug Rat2 whole cell lysate/extract. 7.5 % SDS-PAGE. SESN3 antibody (TA309053) dilution: 1:1000 Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Sestrin-3 (SESN3) antibody

  Rabbit Polyclonal Anti-SESN3 Antibody  
Sestrin-3 (SESN3) Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Sestrin-3 (SESN3) (Center) antibody

Immunohistochemistry analysis in Formalin Fixed, Paraffin Embedded Human pancreas tissue stained with antibody (Center Y335) Cat.-No AP53867PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of Sestrin-3 Antibody (Center Y335) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

SESN3 - human gene knockout kit via CRISPR

SESN3 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

SESN3 - human gene knockout kit via CRISPR

SESN3 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

SESN3 - human gene knockout kit via CRISPR

SESN3 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

SESN3 - human gene knockout kit via CRISPR

SESN3 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

SESN3 overexpression lysate

SESN3 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SESN3 (mGFP-tagged) - Human sestrin 3 (SESN3), 200 uL, >10^7 TU/mL

Lenti ORF particles, SESN3 (mGFP-tagged) - Human sestrin 3 (SESN3), 200 uL, >10^7 TU/mL  
200 µl / €1,110.00
  OriGene Technologies, Inc.

Lenti ORF particles, SESN3 (Myc-DDK tagged) - Human sestrin 3 (SESN3) , 200 uL, >10^7 TU/mL

Lenti ORF particles, SESN3 (Myc-DDK tagged) - Human sestrin 3 (SESN3) , 200 uL, >10^7 TU/mL  
200 µl / €990.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Sesn3 (GFP-tagged) - Mouse sestrin 3 (Sesn3), 200 uL, >10^7 TU/mL

Lenti ORF particles, Sesn3 (GFP-tagged) - Mouse sestrin 3 (Sesn3), 200 uL, >10^7 TU/mL  
200 µl / €1,110.00
  OriGene Technologies, Inc.

Lenti ORF particles, Sesn3 (Myc-DDK-tagged) - Mouse sestrin 3 (Sesn3), 200 uL, >10^7 TU/mL

Lenti ORF particles, Sesn3 (Myc-DDK-tagged) - Mouse sestrin 3 (Sesn3), 200 uL, >10^7 TU/mL  
200 µl / €990.00
  OriGene Technologies, Inc.

12 Item(s)

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