SF3B2 / SAP145 antibody

Principal name

SF3B2 / SAP145 antibody

Alternative names for SF3B2 / SAP145 antibody

Splicing factor 3B subunit 2, SAP-145, SAP 145, SF3b145, SF3b150, Pre-mRNA-splicing factor SF3b 145 kDa subunit, Spliceosome-associated protein 145

SwissProt ID

Q7Z627 (Human)

Gene ID

10992 (SF3B2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), ELISA (detection) (E(detection))

Background of SF3B2 / SAP145 antibody

This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus.

  • LinkedIn