SFRP2 antibody

Principal name

SFRP2 antibody

Alternative names for SFRP2 antibody

SFRP-2, FRP2, FRP-2, SARP1, SARP-1, FKSG12, Secreted frizzled-related protein 2, Frizzled-related protein 2, Secreted apoptosis-related protein 1

SwissProt ID

P97299 (Mouse), Q863H1 (Canfa), Q96HF1 (Human), Q9IA96 (Chick)

Gene ID

6423 (SFRP2)

Available reactivities

Hu (Human), Can (Canine), Ms (Mouse), Rt (Rat), Bov (Bovine), Rb (Rabbit), Eq (Equine), Por (Porcine), Sh (Sheep)

Available hosts

Goat, Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP)

Background of SFRP2 antibody

Secreted frizziled-related protein 2 (Sfrp2) is a member of Sfrp family of proteins, consisting of five members in mammals. The N-terminal region of these proteins shares sequence homology with extracellular Wnt binding domain of frizziled receptors (1). Wnts are a large family of cysteine-rich secreted glycoproteins that control development in various organisms (2). Since Sfrp family of proteins interact directly with Wnts, the Sfrp family of proteins have also been implicated in early embryonic development as well as modulating apoptotic events (3). More specifically, Sfrp2 has been shown to play a role in regulating cell growth and differentiation and it is an essential protein required in eye retinal development and myogenesis (4). Sfrp2 is also known to be a tumor-suppressor gene which is epigenetically silenced in medulloblastoma (5).
Recently it was reported that Sfrp2 is a novel stimulator of angiogenesis (6). Normal expression of this protein stimulates angiogenesis via a calcineurin/NFAT pathway whereas aberrant expression of this protein is usually found in the vasculature of majority of human breast tumors (7). While this protein is overexpressed in breast tumors, it is downregulated in human cervical cancers through promoter hypermethylation (8). This downregulation leads to abnormal activation of Wnt/β-catenin signaling pathway which can be attenuated by restoring the expression of SFRP2, hence suppressing cancer cell growth (8). Sfrp2 is located on human chromosome 4q31.3 and is highly expressed in adipose tissue, intestine and colon. It also expressed in heart, brain, skeletal muscle, pancreas, thymus, prostate, testis and ovary. Sfrp2 is approximately a 35.4kDa protein (295 amino acids).

General readings

Urakami S, Shiina H, Enokida H, Kawakami T, Kawamoto K, Hirata H, Tanaka Y,
Kikuno N, Nakagawa M, Igawa M, Dahiya R.
Combination analysis of hypermethylated Wnt-antagonist family genes as a novel
epigenetic biomarker panel for bladder cancer detection.
Clin Cancer Res. 2006 Apr 1;12(7 Pt 1):2109-16.
PMID: 16609023

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SFRP2 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-SFRP2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA807387)(1:150) Mouse IgG1 OTI6E1 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SFRP2 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-SFRP2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA807497) Mouse IgG2a OTI6C2 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SFRP2 antibody

TA302604 (0.1µg/ml) staining of Human Duodenum lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SFRP2 antibody

WB Suggested Anti-SFRP2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

SFRP2 (C-term) antibody

SFRP2 Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

SFRP2 antibody

SFRP2 polyclonal antibody ( Cat # PAB7603 ) ( 0.1 µg/ml ) staining of human duodenum lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

SFRP2 antibody

Western blot analysis of extracts from HeLa/COLO/HuvEc cells, using SFRP2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €205.00
  Assay Biotech

SFRP2 antibody

Western blot analysis of extracts from HeLa/COLO/HuvEc cells, using SFRP2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €310.00
  Assay Biotech

SFRP2 antibody

Human Jurkat; WB Suggested Anti-SFRP2 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: Jurkat cell lysate; SFRP2 antibody - middle region (ARP56543_P050) in Human Jurkat cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Rb, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

SFRP2 antibody

Western blot analysis of SFRP2 expression in SKNSH (A); Jurkat (B); A431 (C) whole cell lysates. Rabbit Aff - Purified Can, Hu, Ms, Rt IP, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

SFRP2 antibody

Western blot analysis of SFRP2 expression in SKNSH (A); Jurkat (B); A431 (C) whole cell lysates. Rabbit Aff - Purified Can, Hu, Ms, Rt IP, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

SFRP2 antibody

Western blot analysis of SFRP2 expression in SKNSH (A); Jurkat (B); A431 (C) whole cell lysates. Rabbit Aff - Purified Can, Hu, Ms, Rt IP, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

SFRP2 antibody

NB110-74715 (0.1µg/ml) staining of Human Duodenum lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence Goat Aff - Purified Hu E, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

SFRP2 antibody

Western Blot: SFRP2 Antibody [NBP1-56609] - This Anti-SFRP2 antibody was used in Western Blot of Jurkat     tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Can, Hu, Ms WB
50 µg / €440.00
  Novus Biologicals Inc.

SFRP2 antibody

Immunohistochemistry-Paraffin: SFRP2 Antibody [NBP1-83423] - Immunohistochemical staining of human epididymis shows strong membranous and cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

SFRP2 antibody

Western Blot: SFRP2 Antibody (EPR4832) [NBP1-95105] (A) U87-MG and (B) HUVEC cell lysates using anti-SFRP2. Rabbit EPR4832 Purified Hu, Ms, Rt WB
0.1 ml / €480.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SFRP2

SFRP2 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
10 µg / €139.00
  OriGene Technologies, Inc.

SFRP2 (20-295, His-tag)

SFRP2 Human Purified > 85 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

SFRP2 (20-295, His-tag)

SFRP2 Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

19 Item(s)

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