SFRP5 antibody

Principal name

SFRP5 antibody

Alternative names for SFRP5 antibody

SFRP-5, SARP3, SARP-3, FRP1B, FRP-1b, Secreted frizzled-related protein 5, Secreted apoptosis-related protein 3, Frizzled-related protein 1b

SwissProt ID

Q5T4F7 (Human), Q9WU66 (Mouse), Q9XSC1 (Bovin)

Gene ID

6425 (SFRP5)

Available reactivities

Hu (Human), Bov (Bovine), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB)

Background of SFRP5 antibody

Secreted frizziled-related protein 2 (Sfrp2) is a member of Sfrp family of proteins, consisting of five members in mammals. The N-terminal region of these proteins shares sequence homology with extracellular Wnt binding domain of frizziled receptors (1). Wnts are a large family of cysteine-rich secreted glycoproteins that control development in various organisms (2). Since Sfrp family of proteins interact directly with Wnts, the Sfrp family of proteins have also been implicated in early embryonic development as well as modulating apoptotic events (3). More specifically, sfrp5 is implicated in determining the polarity of photoreceptor cells in the retina (4). Furthermore, it is an anti-inflammatory adipokine (5). Sfrp5 is a promising target in cancer treatment because it is known to play an important role in the development of bladder tumor and its downregulation or overexpression is linked with various cancers (6).
Hypermethylation of the promoter region of sfrp5 deactivates this protein, this leads to oncogenic activation of wnt signaling pathway which is common in cancers (7). Therfore, inactivation of sfrp5 has been linked with oral squamous cell carcinoma, ovarian and colorectal cancers (8). Hypermethylation, as well as overexpression of sfrp5 was reported to be seen in pancreatic cancers (9). Sfrp5 is located on human chromosome 10q24.1. It is highly expressed in retinal pigment epithelium. It is also expressed in pancreas and weakly expressed in heart, liver and skeletal muscle. Sfrp5 is approximately a 38kDa protein (317 amino acids).

General readings

Veeck J, Geisler C, et al. (2008). Carcinogenesis. 29(5):991-8.urakami S, Shiina H, et al. (2006). Clin Cancer Res. 12(7 Pt 1):2109-16.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SFRP5 antibody

Western Blot: SFRP5 Antibody -Analysis of human SFRP5 in pancreas lysate with anti SFRP5 at a 1:500 dilution. Rabbit Purified Hu C, E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SFRP5 (Center) antibody

Western blot analysis of SFRP5 Antibody (Center) (AP17741PU-N) in K562 cell line lysates (35ug/lane). SFRP5 (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

SFRP5 (150-200) antibody

SFRP5 Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

SFRP5 (Center) antibody

Immunohistochemistry analysis in Formalin Fixed, Paraffin Embedded Human pancreas tissue stained with SFRP5 Antibody (Center) Cat.-No AP53876PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of SFRP5 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

SFRP5 antibody

Immunohistochemistry-Paraffin: SFRP5 Antibody [NBP1-87089] - Immunohistochemical staining of human oral mucosa shows strong cytoplasmic positivity in squamous epithelial cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SFRP5 (30-317, His-tag)

SFRP5 Human Purified > 85 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

SFRP5 (30-317, His-tag)

SFRP5 Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

SFRP5 overexpression lysate

SFRP5 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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