SFRS1 (SF2) antibody

Principal name

SFRS1 (SF2) antibody

Alternative names for SFRS1 (SF2) antibody

ASF, ASF-1, Alternative-splicing factor 1, SF2P33, Splicing factor arginine/serine-rich 1, pre-mRNA-splicing factor SF2 P33 subunit

SwissProt ID

Q07955 (Human), Q0VCY7 (Bovin), Q3YLA6 (Pig), Q5ZML3 (Chick), Q6NYA0 (Danre), Q6PDM2 (Mouse)

Gene ID

6426 (SRSF1), 110809 (Srsf1)

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection))

Background of SFRS1 (SF2) antibody

SFRS1 is a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site. The protein\'s ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor associated proteins. Multiple transcript variants encoding different isoforms have been found for this gene.Alternative mRNA splicing plays an important role in development and differentiation; many transcripts are spliced differently in distinct cell types and tissues. Both constitutive and alternative splicing occurs on spliceosomes, which are complex particles composed of small nuclear ribonucleoproteins (snRNPs) and non-snRNP proteins. The SR family of non-snRNP splicing factors is characterized by the presence of an RNA recognition motif and a serine- and arginine-rich (SR) domain. SR proteins are required at early stages of spliceosome assembly, have distinct but overlapping specificities for different pre-mRNAs, and can alter splice site choice, suggesting that they may be involved in the regulation of alternative splicing in vivo. Two of the SR proteins, ASF/SF2 (SFRS1) and SC35 (SFRS2; MIM 600813), have been extensively characterized.Alternative mRNA splicing plays an important role in development and differentiation; many transcripts are spliced differently in distinct cell types and tissues. Both constitutive and alternative splicing occurs on spliceosomes, which are complex particles composed of small nuclear ribonucleoproteins (snRNPs) and non-snRNP proteins. The SR family of non-snRNP splicing factors is characterized by the presence of an RNA recognition motif and a serine- and arginine-rich (SR) domain. SR proteins are required at early stages of spliceosome assembly, have distinct but overlapping specificities for different pre-mRNAs, and can alter splice site choice, suggesting that they may be involved in the regulation of alternative splicing in vivo. Two of the SR proteins, ASF/SF2 (SFRS1) and SC35 (SFRS2; MIM 600813), have been extensively characterized (Bermingham et al., 1995).[supplied by OMIM].

General readings

Zuo P., et al. (1993) EMBO J. 12:4727-4737Kohtz J.D., et al. (1994) Nature. 368:119-124

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SFRS1 (SF2) antibody

  Rabbit anti-SFRS1 Polyclonal Antibody  
Western blot analysis of extracts of human brain cell lines, using SFRS1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

SFRS1 (SF2) antibody

  Rabbit Polyclonal Anti-SFRS1 Antibody  
WB Suggested Anti-SFRS1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: HepG2 cell lysateThere is BioGPS gene expression data showing that SRSF1 is expressed in HepG2 Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

SFRS1 (SF2) antibody

  Rabbit Polyclonal Anti-SFRS1 Antibody  
WB Suggested Anti-SFRS1 Antibody Titration: 5.0 ug/ml; ELISA Titer: 1: 312500; Positive Control: HepG2 cell lysateThere is BioGPS gene expression data showing that SRSF1 is expressed in HepG2 Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SFRS1 (SF2) antibody

  Rabbit Polyclonal SF2 Antibody  
SFRS1 (SF2) Rabbit IgG Purified Hu
50 µg / €325.00
  OriGene Technologies, Inc.

SFRS1 (SF2) (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human colon carcinoma reacted with SFRS1 Antibody (C-term), which was Peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Hu P, WB

Regular Price: 0.4 ml / €370.00

Special Price: 0.4 ml / €231.00

  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

SRSF1 - human gene knockout kit via CRISPR

SRSF1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

SRSF1 - human gene knockout kit via CRISPR

SRSF1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Srsf1 - mouse gene knockout kit via CRISPR

Srsf1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Srsf1 - mouse gene knockout kit via CRISPR

Srsf1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Srsf1 - mouse gene knockout kit via CRISPR

Srsf1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Srsf1 - mouse gene knockout kit via CRISPR

Srsf1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SFRS1 (SF2) (transcript variant 1)

  Recombinant protein of human splicing factor, arginine/serine-rich 1 (SFRS1), transcript variant 1  
SFRS1 (SF2) Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

SFRS1 (SF2) (1-248, His-tag)

SFRS1 (SF2) Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

SFRS1 (SF2) (1-248, His-tag)

SFRS1 (SF2) Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SRSF1 (mGFP-tagged) - Human serine/arginine-rich splicing factor 1 (SRSF1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, SRSF1 (mGFP-tagged) - Human serine/arginine-rich splicing factor 1 (SRSF1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, SRSF1 (Myc-DDK tagged) - Human serine/arginine-rich splicing factor 1 (SRSF1), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, SRSF1 (Myc-DDK tagged) - Human serine/arginine-rich splicing factor 1 (SRSF1), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Lenti ORF particles, SRSF1 (Myc-DDK tagged) - Human serine/arginine-rich splicing factor 1 (SRSF1), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, SRSF1 (Myc-DDK tagged) - Human serine/arginine-rich splicing factor 1 (SRSF1), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Srsf1 (GFP-tagged) - Mouse serine/arginine-rich splicing factor 1 (Srsf1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Srsf1 (GFP-tagged) - Mouse serine/arginine-rich splicing factor 1 (Srsf1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Srsf1 (Myc-DDK-tagged) - Mouse serine/arginine-rich splicing factor 1 (Srsf1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Srsf1 (Myc-DDK-tagged) - Mouse serine/arginine-rich splicing factor 1 (Srsf1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

19 Item(s)

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