SFTPD antibody

Principal name

SFTPD antibody

Alternative names for SFTPD antibody

Lung surfactant protein D, SP-D, PSP-D, PSPD, SFTP4, Collectin-7, COLEC7, Pulmonary surfactant-associated protein D

SwissProt ID

P35246 (Bovin), P35247 (Human), P35248 (Rat), P50404 (Mouse), Q9N1X4 (Pig)

Gene ID

25350 (Sftpd), 6441 (SFTPD), 397198, 20390

Available reactivities

Hu (Human), Rt (Rat), Bov (Bovine), Mky (Monkey), Ms (Mouse), Can (Canine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection))

Selected product citations ‐ of BM4005

1. Jakobsen KR, Paulsen BS, Bæk R, Varming K, Sorensen BS, Jørgensen MM. Exosomal proteins as potential diagnostic markers in advanced non-small cell lung carcinoma. J Extracell Vesicles. 2015 Mar 2;4:26659. doi: 10.3402/jev.v4.26659. eCollection 2015. PubMed PMID: 25735706. 
2. Bæk, R;Varming, K;Jørgensen, MM;2016Does smoking, age or gender affect the protein phenotype of extracellular vesicles in plasma? Transfus. Apher. Sci. 2016, 44-52, 55, 1. PubMed PMID: 27470710.

Background of SFTPD antibody

SP-D belongs to the collectin familiy. These proteins are oligomeric proteins composed of carbohydrate-recognition domains (CRD) attached to collagenous regions. They are structurally similar to the ficolins although they make use of different CRD structures: C-type lectin domain for the collectins. The anti-microbial effector mechanisms of SP-D are direct opsonization, neutralization, and agglutination. Thus limiting the infection and concurrently orchestrating the subsequent adaptive immune response. The lung is the major site of synthesis of SP-D, where the molecules are produced and secreted onto the epithelial surface by alveolar type II cells and unciliated bronchial epithelial cells. SP-D is also found in different epithelial cells of the gastrointeststinal tract and in epithelial cells of exocrine glands. SP-D synthesis and secretion increase significantly after inflammatory stress. Increased amounts of SP-D in lavage and tissue, particularly in type II pneumocytes, in Clara cells and in hyperplastic goblet cells are found in inflamed lungs. The localization of SP-D in endocytic vesicles and in lysosomal granules of alveolar macrophages suggests that a receptor-mediated uptake occurs. SP-D binds to apoptotic neutrophils and enhances their clearance by alveolar macrophages.

General readings

1. Schmidt R, Markart P, Ruppert C, Wygrecka M, Kuchenbuch T, Walmrath D, Seeger W, Guenther A.: Time-dependent changes in pulmonary surfactant function and composition in
acute respiratory distress syndrome due to pneumonia or aspiration. Respir Res. 2007 Jul 27;8:55.
2. Hilgendorff A, Schmidt R, Bohnert A, Merz C, Bein G, Gortner L.: Host defence lectins in preterm neonates. Acta Paediatr. 2005 Jun;94(6):794-9.
3. Griese M, Neumann M, von Bredow T, Schmidt R, Ratjen F.: Surfactant in children with malignancies, immunosuppression, fever and pulmonary infiltrates. Eur Respir J. 2002. Nov;20(5):1284-91.
4. Pan T, Nielsen LD, Allen MJ, Shannon KM, Shannon JM, Selman M, Mason RJ.: Serum SPD is a marker of lung injury in rats. Am J Physiol Lung Cell Mol Physiol. 2002 Apr;282(4):L824-32.
5. Kasper M, Albrecht S, Grossmann H, Grosser M, Schuh D, Müller M.: Monoclonal antibodies to surfactant protein D: evaluation of immunoreactivity in normal rat lung and in a radiationinduced
fibrosis model. Exp Lung Res. 1995 Jul-Aug;21(4):577-88.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SFTPD (Conformational epitope) antibody

Immunohistochemical staining of Rat Lung Frozen  Section uing BM4083 antibody Clone IIE11. Mouse IgG2b IIE11 (SPDE) Purified Hu, Rt C, E, WB
0.25 mg / €520.00
  Acris Antibodies GmbH

SFTPD (conformational epitope) antibody

SFTPD Mouse IgG2b IIE11 Biotin Hu, Rt C, P, WB
0.2 mg / €570.00
  Acris Antibodies GmbH

SFTPD antibody

Predicted cell location: Cytoplasm. Positive control: Human tonsil and ovarian cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human tonsil tissue using SFTPD antibody at dilution 1/30, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

SFTPD antibody

Predicted cell location: Cytoplasm. Positive control: Human ovarian and cervical cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human ovarian cancer tissue using SFTPD antibody at dilution 1/30, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

SFTPD antibody

WB Suggested Anti-SFTPD Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Human Thymus Rabbit IgG Purified Can, GP, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

SFTPD antibody

SFTPD Mouse IgG1 IVG8 Purified Hu, Rt E, E(detection), P, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

SFTPD antibody

SFTPD Mouse IgG1 VIF9 Purified Hu, Rt E, E(detection), P, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

SFTPD antibody

SFTPD Mouse IgG1 IIIH3 Purified Hu, Rt E, P, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

SFTPD antibody

Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 2A10 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

SFTPD (Lectin Domain) antibody

Immunohistochemistry: BM4005 SP-D antibody (Clone: VIF11) staining of Rat Lung Frozen Section Mouse IgG1 VIF11 Purified Hu, Rt C, E, P, WB
0.2 mg / €520.00
  Acris Antibodies GmbH

SFTPD (Lectin Domain) antibody

BM4005B SFTPD antibody staining of Frozen Rat Lung Section (Clone VIF11, Biotin Conjugated) Mouse IgG1 VIF11 Biotin Hu, Rt C, E, WB
0.2 mg / €570.00
  Acris Antibodies GmbH

SFTPD antibody

SFTPD Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

SFTPD antibody

SFTPD Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

SFTPD antibody

SFTPD monoclonal antibody (M01), clone 3E6 Western Blot analysis of SFTPD expression in IMR-32 ( Cat # L008V1 ). Mouse IgG1 3E6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SFTPD antibody

Immunoperoxidase of monoclonal antibody to SFTPD on formalin-fixed paraffin-embedded human spleen. [antibody concentration 3 ug/ml] Mouse IgG1 2A10 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SFTPD antibody

Immunofluorescence of monoclonal antibody to SFTPD on HeLa cell . [antibody concentration 10 ug/ml] Mouse IgG2a 2C10 Purified Hu E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SFTPD antibody

Human Thymus; WB Suggested Anti-SFTPD Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: Human Thymus; SFTPD antibody - middle region (ARP41514_P050) in Human Thymus cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

CRISPR

Catalog No. Species Donor Vector  

Sftpd - mouse gene knockout kit via CRISPR

Sftpd - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Sftpd - mouse gene knockout kit via CRISPR

Sftpd - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Sftpd - mouse gene knockout kit via CRISPR

Sftpd - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

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