SGK1 / SGK antibody

Principal name

SGK1 / SGK antibody

Alternative names for SGK1 / SGK antibody

Serine/threonine-protein kinase Sgk1, Serum/glucocorticoid-regulated kinase 1

SwissProt ID

O00141 (Human), Q06226 (Rat), Q9WVC6 (Mouse), Q9XT18 (Rabit)

Gene ID

6446 (SGK1), 20393 (Sgk1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Rb (Rabbit), Ze (Zebrafish), Mky (Monkey), Can (Canine)

Available hosts

Rabbit, Mouse, Goat

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Frozen Sections (C)

Background of SGK1 / SGK antibody

Serum- and glucocorticoid-regulated kinase (SGK) is a serine/threonine protein kinase and a member of the "AGC" subfamily, which includes protein kinases A, G, and C. SGK plays an important role in activating certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. SGK contains a catalytic domain, which is most similar to Akt1 (also known as protein kinase B or PKB). SGK is a downstream target of PI 3-kinase-stimulated growth factor signaling, with 3-phosphoinositidedependent protein kinase 1 (PDK1) capable of phosphorylating the activation- loop of SGK at Threonine-256. The adrenal corticosteroid hormone, Aldosterone, induces the transcription of SGK, which mediates Na + transport by stimulating epithelial sodium channel activity. The SGK promoter contains a glucocorticoid response element and an SP-1 regulatory element, and is a transcriptional target for p53. SGK is also a component of the p38 MAPK-mediated response to hyperosmotic stress. The human SGK gene maps to chromosome 6q23 and encodes the 431-amino acid, 49 kDa SGK protein.

General readings

Maiyar A.C. et al. (1996) J. Biol. Chem.. 271: 12414-12422.Brunet A. et al. (2001) Mol. Cell. Biol. 21:952-65

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SGK1/2 antibody

Immunohistochemical analysis of SGK1/2 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Rb, Rt, Ze ICC/IF, P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

SGK1/2 antibody

Immunohistochemical analysis of SGK1/2 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Rb, Rt, Ze ICC/IF, P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

SGK1/2 antibody

Immunohistochemical analysis of SGK1/2 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Rb, Rt, Ze ICC/IF, P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

SGK1 / SGK antibody

Immunoperoxidase of monoclonal antibody to SGK on formalin-fixed paraffin-embedded human kidney. [antibody concentration 3 ug/ml] Mouse IgG1 4D7-G3 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SGK1 / SGK antibody

Western blot analysis of extracts from Jurkat cells, using SGK (Ab-422) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SGK1 / SGK antibody

Western blot analysis of extracts from HeLa cells treated with Insulin (0.01U/ml, 15mins), using SGK (phospho-Ser422) antibody (#TA314531, Line 1 and 2)The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SGK1 / SGK antibody

Affinity Purified anti-SGK-1 antibody was used at a 15 µg/ml to detect nuclear and cytoplasmic signal in a variety of tissues including adrenal, heart, liver, ovary, pancreas, placenta, skin, spleen, testes, thyroid and uterus. Low to moderate levels of background staining were noted. This image shows SGK-1 staining of human pancreas. Tissue was formalin-fixed and paraffin embedded. Personal Communication, Tina Roush, LifeSpanBiosciences, Seattle, WA. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.5 mg / €325.00
  OriGene Technologies, Inc.

SGK1 / SGK (C-term) antibody

Western blot analysis of SGK1 in human stomach tissue lysate with SGK1 antibody at (A) 1 and (B) 2 ug/mL. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SGK1 / SGK antibody

Western blot analysis of SGK expression in Jurkat whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SGK1 / SGK antibody

Western blot analysis of SGK phosphorylation expression in Insulin treated HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SGK1 / SGK (C-term) antibody

TA326326 (2µg/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining. Goat Aff - Purified Bov, Can, Hu, Ms, Rb, Rt E, P
0.1 mg / €325.00
  OriGene Technologies, Inc.

SGK1 / SGK antibody

Western blot analysis of extracts of various cell lines, using SGK1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

SGK1 / SGK (1-91) antibody

Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2b 3E3 Purified Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

SGK1 / SGK antibody

Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2b 3C4 Purified Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

SGK1 / SGK antibody

Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2b 1C4 Purified Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

SGK1 / SGK antibody

Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 3G8 Purified Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

SGK1 / SGK (C-term) antibody

Western blot analysis of SGK
expression in lysate from Rat
kidney (Lane 1) and 3T3 cells
(Lane 2). Rabbit Aff - Purified Hu, Ms, Rt IP, WB
0.1 mg / €370.00
  Acris Antibodies GmbH

SGK1 / SGK antibody

Immunohistochemistry (IHC) analyzes of SGK antibody (Cat.-No.: AP06580PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

SGK1 / SGK control peptide

SGK1 / SGK
50 µg / €160.00
  Acris Antibodies GmbH

SGK1 / SGK antibody

SGK1 / SGK Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

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