SGK1 / SGK antibody

Principal name

SGK1 / SGK antibody

Alternative names for SGK1 / SGK antibody

Serine/threonine-protein kinase Sgk1, Serum/glucocorticoid-regulated kinase 1

SwissProt ID

O00141 (Human), Q06226 (Rat), Q9WVC6 (Mouse), Q9XT18 (Rabit)

Gene ID

6446 (SGK1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Rb (Rabbit), Chk (Chicken), Ze (Zebrafish), Mky (Monkey)

Available hosts

Rabbit, Mouse, Chicken, Goat

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Flow Cytometry (F), Frozen Sections (C)

Background of SGK1 / SGK antibody

SGK-1 (also called Serine/threonine-protein kinase Sgk1 and Serum/glucocorticoid-regulated kinase 1) is a protein kinase that plays an important role in cellular stress response. SGK1 activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. This kinase mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A and phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, Kv1.3, or EAAT1. SGK1 is localized to the cytoplasm and upon phosphorylation is translocated to the nucleus. The kinase is expressed in most tissues with highest levels in the pancreas, followed by placenta, kidney and lung. Induction occurs upon exposure to glucocorticoids and by excessive extracellular glucose or TGF-beta, in cultured cells. SGK-1 is regulated by phosphorylation. Phosphoinositide 3-kinase (PI3-kinase) pathway promotes phosphorylation at Ser-422 which in turn increases the phosphorylation of Thr-256 by PDPK1. The kinase is ubiquitinated by NEDD4L; which promotes proteasomal degradation.

General readings

Maiyar A.C. et al. (1996) J. Biol. Chem.. 271: 12414-12422.Brunet A. et al. (2001) Mol. Cell. Biol. 21:952-65

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SGK1/2 antibody

Immunohistochemical analysis of SGK1/2 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Rb, Rt, Ze ICC/IF, P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

SGK1/2 antibody

Immunohistochemical analysis of SGK1/2 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Rb, Rt, Ze ICC/IF, P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

SGK1/2 antibody

Immunohistochemical analysis of SGK1/2 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Rb, Rt, Ze ICC/IF, P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

SGK1 / SGK antibody

Immunoperoxidase of monoclonal antibody to SGK on formalin-fixed paraffin-embedded human kidney. [antibody concentration 3 ug/ml] Mouse IgG1 4D7-G3 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SGK1 / SGK antibody

Western blot analysis of extracts from Jurkat cells, using SGK (Ab-422) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SGK1 / SGK antibody

Affinity Purified anti-SGK-1 antibody was used at a 15 µg/ml to detect nuclear and cytoplasmic signal in a variety of tissues including adrenal, heart, liver, ovary, pancreas, placenta, skin, spleen, testes, thyroid and uterus. Low to moderate levels of background staining were noted. This image shows SGK-1 staining of human pancreas. Tissue was formalin-fixed and paraffin embedded. Personal Communication, Tina Roush, LifeSpanBiosciences, Seattle, WA. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.5 mg / €325.00
  OriGene Technologies, Inc.

SGK1 / SGK (C-term) antibody

Western blot analysis of SGK1 in human stomach tissue lysate with SGK1 antibody at (A) 1 and (B) 2 ug/mL. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SGK1 / SGK antibody

Western blot analysis of SGK expression in Jurkat whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SGK1 / SGK (C-term) antibody

TA326326 (2µg/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining. Goat Aff - Purified Bov, Can, Hu, Ms, Rb, Rt E, P
0.1 mg / €325.00
  OriGene Technologies, Inc.

SGK1 / SGK antibody

Western blot analysis of extracts of various cell lines, using SGK1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

SGK1 / SGK (1-91) antibody

Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2b 3E3 Purified Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

SGK1 / SGK antibody

Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2b 3C4 Purified Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

SGK1 / SGK antibody

Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2b 1C4 Purified Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

SGK1 / SGK antibody

Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 3G8 Purified Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

SGK1 / SGK (C-term) antibody

Western blot analysis of SGK
expression in lysate from Rat
kidney (Lane 1) and 3T3 cells
(Lane 2). Rabbit Aff - Purified Hu, Ms, Rt IP, WB
0.1 mg / €370.00
  Acris Antibodies GmbH

SGK1 / SGK antibody

Immunohistochemistry (IHC) analyzes of SGK antibody (Cat.-No.: AP06580PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

SGK1 / SGK antibody

Figure 1. Staining SGK in Pancreas by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Aff - Purified Hu E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

SGK1 / SGK control peptide

SGK1 / SGK
50 µg / €160.00
  Acris Antibodies GmbH

SGK1 / SGK antibody

SGK1 / SGK Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

SGK1 / SGK antibody

SGK1 / SGK Mouse IgG1 4D7-G3 Ascites Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

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