SH2B2 / APS antibody

Principal name

SH2B2 / APS antibody

Alternative names for SH2B2 / APS antibody

SH2B adapter protein 2, SH2 and PH domain-containing adapter protein APS, Adapter protein with pleckstrin homology and Src homology 2 domains

SwissProt ID

O14492 (Human), Q9JID9 (Mouse), Q9Z200 (Rat)

Gene ID

10603 (SH2B2), 114203 (Sh2b2)

Available reactivities

Ms (Mouse), Hu (Human), Rt (Rat)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of SH2B2 / APS antibody

APS (adapter protein with Pleckstrin homology and Src homology 2 domains) a member of the Lnk family, is an adaptor protein that is involved in B-cell signaling, insulin signaling, cytoskeletal reorganization. It is tyrosine phosphorylated by JAK2, KIT and other kinases during B-cell receptor stimulation of many different cytokines, chemokines and leukokines. APS has been shown to inhibit the JAK-STAT pathway in collaboration with c-Cbl. It is located in the cytoplasm in pre-PDGF (platelet derived growth factor) stimulated cells and localizes to the plasma membrane and peripheral regions upon PDGF stimulation.
This protein is expressed in B-cells and mast cells when detected in haematopoietic cell lines yet is also expressed in many different tissues including spleen, prostrate, testis, uterus, small intestine and skeletal muscle.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SH2B2 / APS antibody

Western blot analysis of extracts from HuvEc cells, using SH2B2 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SH2B2 / APS antibody

Western Blot: SH2B2 Antibody [NBP1-32149-  (30 µg of whole cell lysate) A:293T 7.5% SDS PAGE diluted at 1:1000 Rabbit IgG Hu WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SH2B2 / APS

SH2B2 / APS Human > 80 %
Preparation: or Add: Recombint proteins was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

SH2B2 / APS

SH2B2 / APS Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

SH2B2 / APS

SH2B2 / APS Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

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