SH2B3 antibody

Principal name

SH2B3 antibody

Alternative names for SH2B3 antibody

SH2B3, LNK, SH2B adapter protein 3, Lymphocyte-specific adapter protein Lnk, Signal transduction protein Lnk, Lymphocyte adapter protein

SwissProt ID

O09039 (Mouse), P50745 (Rat), Q9UQQ2 (Human)

Gene ID

10019 (SH2B3)

Available reactivities

Hu (Human), Mky (Monkey), Ms (Mouse), Rt (Rat)

Available hosts

Goat, Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of SH2B3 antibody

LNK is an SH2-containing adaptor protein, which regulates cytokine receptor-mediated and growth factor pathways, and plays an essential role in B cell lymphopoiesis.
LNK mRNA is preferentially expressed in lymph node and spleen lymphocytes and the expression of LNK in vascular endothelial cells (ECs), increases in response to TNFalpha. The role of LNK as a negative regulator, includes the down regulation of the pro-inflammatory molecules VCAM-1 and E-selectin induced by TNFalpha, modulation of P13-kinase and MAPK ERK1/2 activity, and negative regulation of Thrombopoietin-mediated cell proliferation and endomitosis in hematopoietic cell lines.

General readings

Li Y, He X, Schembri-King J, Jakes S, Hayashi J. Cloning and characterization of human Lnk, an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation. J Immunol. 2000 May 15;164(10):5199-206.
PMID: 10799879

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SH2B3 antibody

Anti-SH2B3 mouse monoclonal antibody (TA502748) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SH2B3(RC218359 ). Mouse IgG2a OTI2B11 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SH2B3 antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-SH2B3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502764) Mouse IgG1 OTI2D8 Purified Hu F, ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

SH2B3 antibody

Anti-SH2B3 mouse monoclonal antibody (TA502933) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SH2B3(RC218359 ). Mouse IgG1 OTI2C9 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SH2B3 antibody

TA302531 (0.3µg/ml) staining of MOLT4 lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SH2B3 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SH2B3 (RC218359, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SH2B3. Mouse IgG1 OTI6F11 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SH2B3 antibody

Anti-SH2B3 mouse monoclonal antibody (TA502762) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SH2B3(RC218359 ). Mouse IgG1 OTI1E6 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SH2B3 antibody

Anti-SH2B3 mouse monoclonal antibody (TA503069) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SH2B3(RC218359 ). Mouse IgG1 OTI1F6 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SH2B3 antibody

SH2B3 Goat IgG Purified Hu WB
0.1 mg / €420.00
  Acris Antibodies GmbH

SH2B3 antibody

SH2B3 Rabbit Purified Hu, Mky, Ms, Rt C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

SH2B3 antibody

HEK293 overexpressing SH2B3 and probed with SH2B3 polyclonal antibody ( Cat # PAB6669 ) ( mock transfection in first lane ), tested by Origene. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

SH2B3 antibody

Western blot analysis of LNK expression in HEK293T (A); Raw264.7 (B); H9C2 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

SH2B3 antibody

Western blot analysis of LNK expression in HEK293T (A); Raw264.7 (B); H9C2 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

SH2B3 antibody

Western blot analysis of LNK expression in HEK293T (A); Raw264.7 (B); H9C2 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

SH2B3 antibody

Western Blot: LNK Antibody [NB100-2295] - NB100-2295 (0.3ug/ml) staining of MOLT4 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Ig Fraction Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SH2B3

SH2B3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

15 Item(s)

per page
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