SHANK1 antibody

Principal name

SHANK1 antibody

Alternative names for SHANK1 antibody

SSTR-interacting protein, SSTRIP, SPANK-1, SPANK1, Synamon, SH3 and multiple ankyrin repeat domains protein 1, Somatostatin receptor-interacting protein

SwissProt ID

Q9WV48 (Rat), Q9Y566 (Human)

Gene ID

78957 (Shank1), 50944 (SHANK1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Immunoprecipitation (IP)

Background of SHANK1 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins (3).
Shank1 specifically might be relevant to human autism spectrum disorders, due to its differential role in specific cognitive processes, along with its importance for synapse structure and function in vivo (4).

General readings

Naisbitt et al. (1999). Neuron. 23:569-582.

9 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SHANK1 antibody

Immunohistochemistry: SHANK1a Antibody - Immunohistochemical staining of mouse retina using anti-SHANK1a. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SHANK1 antibody

Western Blot: SHANK1 Antibody - Analysis of SHANK1 in Rat Brain lysate at a 1:500 dilution. Rabbit Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SHANK1 (469-691) antibody

Western blot analysis of Shank1 in rat brain membrane lysates using a 1:1000 dilution of the antibody Mouse IgG1 S22-21 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SHANK1 antibody

Adult rat brain membrane immunoblot. Mouse IgG1 N22/21 Supernatant Hu, Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

SHANK1 antibody

Adult rat brain membrane immunoblot. Mouse IgG1 N22/21 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

SHANK1 antibody

SHANK1 Mouse IgG2a 8F7 Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SHANK1 (N-term) antibody

SHANK1 Rabbit Purified Hu, Ms, Rt WB
0.1 ml / €250.00
  Neuromics Antibodies

SHANK1 (C-term) antibody

SHANK1 Rabbit Aff - Purified Hu, Ms, Rt C, ICC/IF, P, WB
0.1 ml / €310.00
  Neuromics Antibodies

SHANK1 antibody

Immunohistochemistry-Paraffin: SHANK1 Antibody [NBP1-87016] Immunohistochemical staining of human pancreas shows distinct positivity in intercalated duct membranes. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

9 Item(s)

per page
  • LinkedIn