SHANK2 antibody

Principal name

SHANK2 antibody

Alternative names for SHANK2 antibody

Cortactin-binding protein 1, CORTBP1, PROSAP1, SPANK-3, SPANK3, KIAA1022, SH3 and multiple ankyrin repeat domains protein 2, Proline-rich synapse-associated protein 1

SwissProt ID

Q52KW0 (Xenla), Q80Z38 (Mouse), Q9QX74 (Rat), Q9UPX8 (Human)

Gene ID

22941 (SHANK2), 171093 (Shank2), 210274

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Paraffin Sections (P)

Background of SHANK2 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.
There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins (3). Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Studies suggest that Shank2 is expressed in the neurons of the developing retina, and could play a role in the neuronal differentiation of the developing retina (4). Other recent studies suggest that the disruption of glutamate receptors at the Shankpostsynaptic platform could contribute to the destruction of the postsynaptic density, which underlies the synaptic dysfunction and loss in Alzheimer's disease (5).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Pan Shank antibody

Cultured rat hippocampal neuron immunofluorescence: N23B/49 (Pan-Shank) = red, rabbit anti-PSD-95 = green, merge = yellow (bottom right). Image courtesy of Dr. Albert Hung, Picower Institute, MIT. Mouse IgG1 N23B/49 Supernatant Hu, Ms, Rt C, ICC/IF, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

Pan Shank antibody

Cultured rat hippocampal neuron immunofluorescence: N23B/49 (Pan-Shank) = red, rabbit anti-PSD-95 = green, merge = yellow (bottom right). Image courtesy of Dr. Albert Hung, Picower Institute, MIT. Mouse IgG1 N23B/49 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

Shank (Pan) (84-309) antibody

  Mouse Monoclonal Anti-SHANK (pan) Antibody  
Western blot analysis of pan-shank in rat brain membrane lysates using a 1:1000 dilution of the antibody Mouse IgG1 S23b-49 Purified Hu, Ms, Rt ICC/IF, IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SHANK2 (84-309) antibody

  Mouse Monoclonal anti-shank2 Antibody  
Western blot analysis of Shank2in rat brain membrane lysates using a 1:1000 dilution of TA309475. Mouse IgG1 S23b-6 Purified Hu, Rt C, ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SHANK2 antibody

Transfected cell immunoblot: extracts of COS-1 cells transiently transfected with Shank1, Shank2 or Shank3 plasmids and probed with N23B/6 TC supe (left panel) or a monoclonal lane loading control (right panel). Mouse IgG1 N23B/6 Supernatant Hu, Ms, Rt C, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

SHANK2 antibody

Transfected cell immunoblot: extracts of COS-1 cells transiently transfected with Shank1, Shank2 or Shank3 plasmids and probed with N23B/6 TC supe (left panel) or a monoclonal lane loading control (right panel). Mouse IgG1 N23B/6 Purified Hu, Ms, Rt C, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

SHANK2 (Center) antibody

Western blot analysis of SHANK2 Antibody (Center) Cat.-No AP53906PU-N in Mouse bladder tissue lysates (35ug/lane).This demonstrates the SHANK2 antibody detected the SHANK2 protein (arrow). Rabbit Ig Aff - Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

SHANK2 antibody

Western blot analysis of extracts from RAW264.7/Jurkat/HepG2/COLO cells, using SHANK2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €230.00
  Assay Biotech

SHANK2 antibody

Western blot analysis of extracts from RAW264.7/Jurkat/HepG2/COLO cells, using SHANK2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

SHANK2 - human gene knockout kit via CRISPR

SHANK2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

SHANK2 - human gene knockout kit via CRISPR

SHANK2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

SHANK2 - human gene knockout kit via CRISPR

SHANK2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

SHANK2 - human gene knockout kit via CRISPR

SHANK2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Shank2 - mouse gene knockout kit via CRISPR

Shank2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Shank2 - mouse gene knockout kit via CRISPR

Shank2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Shank2 - mouse gene knockout kit via CRISPR

Shank2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Shank2 - mouse gene knockout kit via CRISPR

Shank2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SHANK2 (mGFP-tagged)-Human SH3 and multiple ankyrin repeat domains 2 (SHANK2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, SHANK2 (mGFP-tagged)-Human SH3 and multiple ankyrin repeat domains 2 (SHANK2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €2,460.00
  OriGene Technologies, Inc.

Lenti ORF particles, SHANK2 (Myc-DDK-tagged)-Human SH3 and multiple ankyrin repeat domains 2 (SHANK2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, SHANK2 (Myc-DDK-tagged)-Human SH3 and multiple ankyrin repeat domains 2 (SHANK2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €2,220.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Shank2 (GFP-tagged) - Mouse SH3/ankyrin domain gene 2 (Shank2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Shank2 (GFP-tagged) - Mouse SH3/ankyrin domain gene 2 (Shank2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €2,130.00
  OriGene Technologies, Inc.

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