SHANK3 antibody

Principal name

SHANK3 antibody

Alternative names for SHANK3 antibody

PROSAP2, PSAP2, SPANK-2, SPANK2, KIAA1650, SH3 and multiple ankyrin repeat domains protein 3, Proline-rich synapse-associated protein 2

SwissProt ID

Q4ACU6 (Mouse), Q9BYB0 (Human), Q9JLU4 (Rat)

Gene ID

85358 (SHANK3), 59312 (Shank3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Enzyme Immunoassay (E)

Background of SHANK3 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.
There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2).
Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins (3). Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Shank proteins are also crucial in receptor tyrosine kinase signaling; specifically, Shank3 can mediate Erk-MAPK and P13K signaling which is crucial for tubule formation (4). Shank3 is also one of the latest genes to be associated with autism. A mutation of a single copy of Shank3 on chromosome 22q13 can result in language and/or social communication disorders (5).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SHANK1/3 antibody

Adult rat hippocampus immunohistochemistry Mouse IgG2a N367/51 Supernatant Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

SHANK3 antibody

Immunohistochemistry-Paraffin: SHANK3 Antibody [NBP1-20197] - IHC on rat spinal cord (paraffin section) using Rabbit antibody to internal region of SHANK3 (ProSAP2): whole serum at 1 : 200 dilution incubated overnight at room temperature, developed with DAB/Ni and counterstained with hematoxylin. Rabbit Serum Hu, Ms, Rt P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

SHANK3 (840-857) antibody

Western blot analysis of Shank3 in rat brain membrane lysates using a 1:1000 dilution of TA309476. Mouse IgG2b S69-46 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SHANK3 antibody

Western blot analysis of SHANK3 in 3T3 cell lysate with SHANK3 antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide. Rabbit Purified Hu, Ms E, P, WB
0.1 mg / €379.00
  OriGene Technologies, Inc.

SHANK3 antibody

Adult rat hippocampus immunohistochemistry. Mouse IgG2b N69/46 Supernatant Hu, Ms, Rt C, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

SHANK3 antibody

Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and COS cells transiently transfected with HA-tagged Shank1, Shank2, Shank3 or untagged Kv2.1 plasmid and probed with N367/62 (left) or N23B/49 (right) TC supe. Mouse IgG2a N367/62 Supernatant Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

SHANK3 antibody

Adult rat hippocampus immunohistochemistry. Mouse IgG2b N69/46 Purified Hu, Ms, Rt C, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

SHANK3 antibody

Adult rat hippocampus immunohistochemistry Mouse IgG2a N367/51 Purified Ms, Rt C, ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

SHANK3 antibody

Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and COS cells transiently transfected with HA-tagged Shank1, Shank2, Shank3 or untagged Kv2.1 plasmid and probed with N367/62 (left) or N23B/49 (right) TC supe. Mouse IgG2a N367/62 Purified Ms, Rt C, ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

SHANK3 antibody

SHANK3 Mouse S69-46 Purified Hu, Ms, Rt IP, P, WB
0.1 mg / €450.00
  Novus Biologicals Inc.

10 Item(s)

per page
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