SHISA4 antibody

Principal name

SHISA4 antibody

Alternative names for SHISA4 antibody

Protein shisa-4, C1orf40, TMEM58, Transmembrane protein 58

SwissProt ID

Q8CA71 (Mouse), Q96DD7 (Human)

Gene ID

149345 (SHISA4)

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of SHISA4 antibody

SHISA4 Antibody: SHISA4 plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT sigling. The Shisa family of single-transmembrane proteins is characterized by an N-termil cysteine-rich domain and a proline-rich C-termil region. Its founding member, Xenopus Shisa, promotes head development by antagonizing Wnt and FGF sigling. Shisa physically interacted with immature forms of the Wnt receptor Frizzled and the FGF receptor within the ER and inhibited their posttranslatiol maturation and trafficking to the cell surface. Loss of Shisa function sensitized the neuroectoderm to Wnt sigling and suppressed head formation during gastrulation.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SHISA4 antibody

Western blot analysis of SHISA4 in human brain tissue lysate with SHISA4 antibody at (A) 1 and (B) 2 ug/mL. Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

SHISA4 overexpression lysate

SHISA4 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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