SHOC2 antibody

Principal name

SHOC2 antibody

Alternative names for SHOC2 antibody

SHOC-2, Protein soc-2 homolog, Protein sur-8 homolog, SOC2, SUR8, KIAA0862, Leucine-rich repeat protein SHOC-2

SwissProt ID

A6QLV3 (Bovin), O88520 (Mouse), Q6AYI5 (Rat), Q9UQ13 (Human)

Gene ID

8036 (SHOC2), 56392 (Shoc2), 309548

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Rabbit

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of SHOC2 antibody

SHOC2 protein participates in protein binding / transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. It is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and cytoplasmically localized. SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade, which is elicited by EGL-15 and LET-23 and mediated by LET-60. SHOC2 together with protein phosphatase 1c (PP1c) forms a highly specific M-Ras effector complex and is essential for activation of the MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of SHOC2 expression inhibits MAPK, but not PI3K activity. The SHOC2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. Recent studies show that aberrantly acquired N-myristoylation of SHOC2 causes human disease Noonan-like syndrome with loose anagen hair.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SHOC2 antibody

  Rabbit Polyclonal SHOC2 Antibody  
Western blot analysis of SHOC2 in Jurkat cell lysate with SHOC2 antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SHOC2 antibody

  Rabbit Polyclonal Anti-SHOC2 Antibody  
Host: Rabbit; Target Name: SHOC2; Sample Tissue: Fetal Kidney lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

SHOC2 antibody

SHOC2 Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

SHOC2 - human gene knockout kit via CRISPR

SHOC2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

SHOC2 - human gene knockout kit via CRISPR

SHOC2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

SHOC2 - human gene knockout kit via CRISPR

SHOC2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

SHOC2 - human gene knockout kit via CRISPR

SHOC2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Shoc2 - mouse gene knockout kit via CRISPR

Shoc2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Shoc2 - mouse gene knockout kit via CRISPR

Shoc2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Shoc2 - mouse gene knockout kit via CRISPR

Shoc2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Shoc2 - mouse gene knockout kit via CRISPR

Shoc2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SHOC2

  Recombinant protein of human soc-2 suppressor of clear homolog (C. elegans) (SHOC2)  
SHOC2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

SHOC2 overexpression lysate

SHOC2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SHOC2 (mGFP-tagged) - Human soc-2 suppressor of clear homolog (C. elegans) (SHOC2), 200 uL, >10^7 TU/mL

Lenti ORF particles, SHOC2 (mGFP-tagged) - Human soc-2 suppressor of clear homolog (C. elegans) (SHOC2), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, SHOC2 (Myc-DDK tagged) - Human soc-2 suppressor of clear homolog (C. elegans) (SHOC2) , 200 uL, >10^7 TU/mL

Lenti ORF particles, SHOC2 (Myc-DDK tagged) - Human soc-2 suppressor of clear homolog (C. elegans) (SHOC2) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Shoc2 (GFP-tagged) - Mouse soc-2 (suppressor of clear) homolog (C. elegans) (cDNA clone MGC:31051 IMAGE:4014650), 200 uL, >10^7 TU/mL

Lenti ORF particles, Shoc2 (GFP-tagged) - Mouse soc-2 (suppressor of clear) homolog (C. elegans) (cDNA clone MGC:31051 IMAGE:4014650), 200 uL, >10^7 TU/mL  
200 µl / €1,170.00
  OriGene Technologies, Inc.

Lenti ORF particles, Shoc2 (GFP-tagged) - Mouse soc-2 (suppressor of clear) homolog (C. elegans) (Shoc2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Shoc2 (GFP-tagged) - Mouse soc-2 (suppressor of clear) homolog (C. elegans) (Shoc2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,230.00
  OriGene Technologies, Inc.

Lenti ORF particles, Shoc2 (GFP-tagged) - Mouse soc-2 (suppressor of clear) homolog (C. elegans) (Shoc2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Shoc2 (GFP-tagged) - Mouse soc-2 (suppressor of clear) homolog (C. elegans) (Shoc2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,170.00
  OriGene Technologies, Inc.

Lenti ORF particles, Shoc2 (Myc-DDK-tagged) - Mouse soc-2 (suppressor of clear) homolog (C. elegans) (cDNA clone MGC:31051 IMAGE:4014650), 200 uL, >10^7 TU/mL

Lenti ORF particles, Shoc2 (Myc-DDK-tagged) - Mouse soc-2 (suppressor of clear) homolog (C. elegans) (cDNA clone MGC:31051 IMAGE:4014650), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, Shoc2 (Myc-DDK-tagged) - Mouse soc-2 (suppressor of clear) homolog (C. elegans) (Shoc2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Shoc2 (Myc-DDK-tagged) - Mouse soc-2 (suppressor of clear) homolog (C. elegans) (Shoc2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,100.00
  OriGene Technologies, Inc.

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