SHOC2 antibody

Principal name

SHOC2 antibody

Alternative names for SHOC2 antibody

SHOC-2, Protein soc-2 homolog, Protein sur-8 homolog, SOC2, SUR8, KIAA0862, Leucine-rich repeat protein SHOC-2

SwissProt ID

A6QLV3 (Bovin), O88520 (Mouse), Q6AYI5 (Rat), Q9UQ13 (Human)

Gene ID

8036 (SHOC2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Immunoprecipitation (IP), Paraffin Sections (P), Western blot / Immunoblot (WB), Frozen Sections (C)

Background of SHOC2 antibody

SHOC2 protein participates in protein binding / transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. It is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and cytoplasmically localized. SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade, which is elicited by EGL-15 and LET-23 and mediated by LET-60. SHOC2 together with protein phosphatase 1c (PP1c) forms a highly specific M-Ras effector complex and is essential for activation of the MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of SHOC2 expression inhibits MAPK, but not PI3K activity. The SHOC2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. Recent studies show that aberrantly acquired N-myristoylation of SHOC2 causes human disease Noonan-like syndrome with loose anagen hair.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SHOC2 antibody

Western blot analysis of SHOC2 in Jurkat cell lysate with SHOC2 antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SHOC2 antibody

Host: Rabbit; Target Name: SHOC2; Sample Tissue: Fetal Kidney lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

SHOC2 Control Peptide

SHOC2
50 µg / €160.00
  Acris Antibodies GmbH

SHOC2 antibody

SHOC2 Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

SHOC2 antibody

Immunohistochemistry-Paraffin: SUR-8 Antibody [NBP1-77041] - Human spleen tissue with SHOC2 antibody at 5 ug/mL._x000d_ Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

SHOC2 antibody

Immunohistochemistry-Paraffin: SUR-8 Antibody [NBP1-87831] - Immunohistochemical staining of human kidney shows moderate cytoplasmic positivity in cells in tubules. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SHOC2

SHOC2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

SHOC2

SHOC2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

SHOC2

SHOC2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

SHOC2 overexpression lysate

SHOC2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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