SIGIRR / TIR8 antibody

Principal name

SIGIRR / TIR8 antibody

Alternative names for SIGIRR / TIR8 antibody

UNQ301/PRO342, Single Ig IL-1-related receptor, Single Ig IL-1R-related molecule, Single immunoglobulin domain-containing IL1R-related protein, Toll/interleukin-1 receptor 8

SwissProt ID

Q4V892 (Rat), Q6IA17 (Human), Q9JLZ8 (Mouse)

Gene ID

59307 (SIGIRR), 24058 (Sigirr), 309106

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Chk (Chicken), Rt (Rat), Ze (Zebrafish)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of SIGIRR / TIR8 antibody

SIGIRR is a member of the Toll-like receptor-interleukin 1 receptor superfamily. Members of this family are defined by the presence of an intracellular Toll-IL-1R (TIR) domain. The Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). SIGIRR was originally identified through database analysis and was shown to have only one Ig domain as opposed to the normal three Ig folds seen in the TIR family (3). Similar to ST2, another TIR family member, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor signaling (4,5). However, SIGIRR inhibits TLR-IL-1R signaling by dimerizing with TLR4, TLR5, TLR9, and IL-1R. It also associates with the down-stream TLR signaling proteins IRAK and TRAF6 in an IL-1-dependent fashion (4).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SIGIRR / TIR8 (C-term) antibody

  Rabbit Polyclonal SIGIRR Antibody  
Western blot analysis of SIGIRR in A549 cell lysate with SIGIRR antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL. Rabbit IgG Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SIGIRR / TIR8 (transcript variant 3)

  Purified recombinant protein of Homo sapiens single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (SIGIRR), transcript variant 3  
SIGIRR / TIR8 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

SIGIRR / TIR8 (transcript variant 2)

  Recombinant protein of human single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (SIGIRR), transcript variant 2  
SIGIRR / TIR8 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

SIGIRR / TIR8 (transcript variant 1)

  Recombinant protein of human single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (SIGIRR), transcript variant 1  
SIGIRR / TIR8 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Lysates

Catalog No.    

SIGIRR overexpression lysate

SIGIRR overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

SIGIRR overexpression lysate

SIGIRR overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

SIGIRR overexpression lysate

SIGIRR overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SIGIRR (mGFP-tagged) - Human single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (SIGIRR), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, SIGIRR (mGFP-tagged) - Human single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (SIGIRR), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, SIGIRR (mGFP-tagged) - Human single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (SIGIRR), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, SIGIRR (mGFP-tagged) - Human single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (SIGIRR), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, SIGIRR (mGFP-tagged) - Human single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (SIGIRR), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, SIGIRR (mGFP-tagged) - Human single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (SIGIRR), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, SIGIRR (Myc-DDK tagged) - Human single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (SIGIRR), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, SIGIRR (Myc-DDK tagged) - Human single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (SIGIRR), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, SIGIRR (Myc-DDK tagged) - Human single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (SIGIRR), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, SIGIRR (Myc-DDK tagged) - Human single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (SIGIRR), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, SIGIRR (Myc-DDK tagged) - Human single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (SIGIRR), transcript variant 3 , 200 uL, >10^7 TU/mL

Lenti ORF particles, SIGIRR (Myc-DDK tagged) - Human single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (SIGIRR), transcript variant 3 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Sigirr (GFP-tagged) - Mouse single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (Sigirr), 200 uL, >10^7 TU/mL

Lenti ORF particles, Sigirr (GFP-tagged) - Mouse single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (Sigirr), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Sigirr (Myc-DDK-tagged) - Mouse single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (Sigirr), 200 uL, >10^7 TU/mL

Lenti ORF particles, Sigirr (Myc-DDK-tagged) - Mouse single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (Sigirr), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Sigirr (GFP-tagged ORF) - Rat single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (Sigirr), 200 uL, >10^7 TU/mL

Lenti ORF particles, Sigirr (GFP-tagged ORF) - Rat single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (Sigirr), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Sigirr (Myc-DDK-tagged ORF) - Rat single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (Sigirr), 200 uL, >10^7 TU/mL

Lenti ORF particles, Sigirr (Myc-DDK-tagged ORF) - Rat single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (Sigirr), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

17 Item(s)

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