SIGLEC12 antibody

Principal name

SIGLEC12 antibody

Alternative names for SIGLEC12 antibody

Siglec-12, SIGLECL1, Siglec-L1, SLG, Sialic acid-binding Ig-like lectin 12, Sialic acid-binding Ig-like lectin-like 1

SwissProt ID

Q91Y57 (Mouse), Q96PQ1 (Human)

Gene ID

89858 (SIGLEC12)

Available reactivities

Hu (Human), Chimp (Chimpanzee), Bov (Bovine), Rt (Rat), Ms (Mouse), Eq (Equine), Por (Porcine), Ze (Zebrafish)

Available hosts

Goat, Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of SIGLEC12 antibody

Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. SIGLEC12 is a member of the SIGLEC3-like subfamily of SIGLECs. SIGLEC12, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor.Western blots using four different antibodies against four unique regions of this protein target confirm the same apparent molecular weight in our tests.Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.

General readings

Angata,T., (2001) J. Biol. Chem. 276 (43), 40282-40287

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SIGLEC12 antibody

WB Suggested Anti-SIGLEC12 Antibody Titration: 0.2-1 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Eq, Hu, Por, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

SIGLEC12 antibody

WB Suggested Anti-SIGLEC12 Antibody Titration: 0.2-1 ug/ml; Positive Control: Jurkat cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

SIGLEC12 antibody

WB Suggested Anti-SIGLEC12 Antibody Titration: 0.2-1 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

SIGLEC12 (C-term) antibody

Western blot analysis of SIGLEC12 Antibody (C-term) (AP18196PU-N) in mouse bladder tissue lysates (35ug/lane). SIGLEC12 (arrow) was detected using the purified Pab. Rabbit Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

SIGLEC12 antibody

Western Blot analysis of SIGLEC12 expression in transfected 293T cell line (H00089858-T01) by SIGLEC12 MaxPab polyclonal antibody.

Lane 1: SIGLEC12 transfected lysate(65.45 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

SIGLEC12 antibody

SIGLEC12 Mouse IgG2a 1D1 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SIGLEC12 antibody

SIGLEC12 Goat Chimp, Hu E
0.1 mg / €390.00
  Abnova Taiwan Corp.

SIGLEC12 antibody

Human HepG2; WB Suggested Anti-SIGLEC12 Antibody Titration: 0.2-1 ug/ml. Positive Control: HepG2 cell lysate; SIGLEC12 antibody - N-terminal region (ARP50183_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Bov, Hu, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

SIGLEC12 antibody

Human Jurkat; WB Suggested Anti-SIGLEC12 Antibody Titration: 0.2-1 ug/ml. Positive Control: Jurkat cell lysate; SIGLEC12 antibody - N-terminal region (ARP50235_P050) in Human Jurkat cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

SIGLEC12 antibody

Human HepG2; WB Suggested Anti-SIGLEC12 Antibody Titration: 0.2-1 ug/ml. Positive Control: HepG2 cell lysate; SIGLEC12 antibody - N-terminal region (ARP50236_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

SIGLEC12 antibody

Western Blot: SIGLECL1 Antibody [NBP1-59241] - This Anti-SIGLEC12 antibody was used in Western Blot of HepG2 tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

SIGLEC12 antibody

Western Blot: SIGLECL1 Antibody [NBP1-59243] - This Anti-SIGLEC12 antibody was used in Western Blot of Jurkat tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SIGLEC12 (transcript variant 1)

SIGLEC12 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

SIGLEC12

SIGLEC12 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue
2 µg / €300.00
  Abnova Taiwan Corp.

SIGLEC12

SIGLEC12 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

SIGLEC12

SIGLEC12 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

SIGLEC12

SIGLEC12 Human Purified
10 µg / €380.00
  Abnova Taiwan Corp.

SIGLEC12

SIGLEC12 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

SIGLEC12

SIGLEC12 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

SIGLEC12 293T Cell Transient Overexpression Lysate(Denatured)

SIGLEC12 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

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