SIGMAR1 / OPRS1 antibody

Principal name

SIGMAR1 / OPRS1 antibody

Alternative names for SIGMAR1 / OPRS1 antibody

Sigma1-receptor, Sigma1R, SIG-1R, SRBP, SR-BP, AAG8, Sigma non-opioid intracellular receptor 1, Sigma 1-type opioid receptor, SR31747-binding protein, Aging-associated gene 8 protein

SwissProt ID

O55242 (Mouse), Q58DH7 (Bovin), Q5ZL84 (Chick), Q60492 (Cavpo), Q6DCU6 (Xenla), Q7ZWG9 (Danre), Q99720 (Human), Q9R0C9 (Rat)

Gene ID

10280 (SIGMAR1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of SIGMAR1 / OPRS1 antibody

The sigma (s) receptor (sigma-1R, Oprs1 protein, opioid receptor sigma 1) and its agonists are implicated in a variety of cellular functions, biological processes and diseases, including cancer biology, psychosis, regulation of neurotransmitter function, motor, endocrine and immune systems. Two sigma receptors, -1 and -2 are presently known and classified based on their ability to bind a variety of ligands. The sigma-1 receptor interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. It is distinct from any known receptor class and lacks significant homology to known mammalian proteins but possesses some homology with fungal sterol isomerases. The predicted structure of this 25 kDa protein depicts two transmembrane domains with both N- and C-terminal tails residing in the cytoplasm.
The sigma-1 receptor is highly expressed in the central nervous system, heart, ovary, kidney, testes, liver, placenta and embryonic stem cells. Both sigma receptors are also highly expressed in tumor cell lines from various tissues, including small- and non-small-cell lung carcinoma, large-cell carcinoma, renal carcinoma, colon carcinoma, sarcoma, brain tumors, breast cancer, emlanoma, glioblastoma, neuroblastoma and prostate cancer. The exact mechanism how sigma-1R affects cancer biology is not known. Some hypotheses include modulation of ion channel activity, cytoskeletal proteins such as ankyrin, intracellular calcium levels, or sphingolipid levels1. Recent evidence also suggests that sigma-1R is important in the compartmentalization / transport of ER-synthesized lipids. Two polymorphisms of the sigma-1R gene, which decrease expression of the gene, are associated with occurrence of Alzheimer's disease.

12 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SIGMAR1 / OPRS1 (Center) antibody

Western blot analysis of OPRS1 (arrow) using rabbit polyclonal OPRS1 Antibody (Center) (Cat.#TA302032).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the OPRS1 gene (Lane 2) (Origene Technologies). Rabbit Ig Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SIGMAR1 / OPRS1 (N-term) antibody

Western blot analysis of OPRS1 (arrow) using rabbit polyclonal OPRS1 Antibody (N-term) (Cat.#TA302033).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the OPRS1 gene (Lane 2) (Origene Technologies). Rabbit Ig Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SIGMAR1 / OPRS1 antibody

Western blot analysis of extracts of various cell lines, using SIGMAR1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

SIGMAR1 / OPRS1 pSer1 antibody

SIGMAR1 / OPRS1 Rabbit Serum Hu E, ICC/IF, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

SIGMAR1 / OPRS1 antibody

Western blot analysis of OPRS1 ( arrow ) using rabbit OPRS1 polyclonal antibody ( Cat # PAB2593 ) . 293 cell lysates ( 2 µg/lane ) either nontransfected ( Lane 1 ) or transiently transfected with the OPRS1 gene ( Lane 2 ) ( Origene Technologies ) . Rabbit Hu E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

SIGMAR1 / OPRS1 antibody

Western blot analysis of OPRS1 ( arrow ) using rabbit OPRS1 polyclonal antibody ( Cat # PAB2594 ) . 293 cell lysates ( 2 µg/lane ) either nontransfected ( Lane 1 ) or transiently transfected with the OPRS1 gene ( Lane 2 ) ( Origene Technologies ) . Rabbit Hu, Ms E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

SIGMAR1 / OPRS1 antibody

Immunohistochemistry-Paraffin: OPRS1 Antibody [NBP1-82479] - Immunohistochemical staining of human small intestine shows distinct positivity in glandular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SIGMAR1 / OPRS1 (transcript variant 1)

SIGMAR1 / OPRS1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

SIGMAR1 / OPRS1

SIGMAR1 / OPRS1 Human
2 µg / €300.00
  Abnova Taiwan Corp.

SIGMAR1 / OPRS1

SIGMAR1 / OPRS1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

SIGMAR1 / OPRS1

SIGMAR1 / OPRS1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

SIGMAR1 overexpression lysate

SIGMAR1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

12 Item(s)

per page
  • LinkedIn