SIN3A antibody

Principal name

SIN3A antibody

Alternative names for SIN3A antibody

Paired amphipathic helix protein Sin3a, Transcriptional corepressor Sin3a, Histone deacetylase complex subunit Sin3a

SwissProt ID

Q60520 (Mouse), Q96ST3 (Human)

Gene ID

25942 (SIN3A), 20466 (Sin3a)

Available reactivities

Hu (Human), Chk (Chicken), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of SIN3A antibody

SIN3 was origilly identified as a negative regulator of transcription in budding yeast. Since then, three isoforms of the SIN3 proteins have been identified in mammalian cells, as products of two different genes, SIN3A and SIN3B. Both SIN3A and SIN3B are nuclear proteins that function as scaffolding subunits for the multi-subunit SIN3 transcriptiol repressor complex, containing SIN3A or SIN3B, HDAC1, HDAC2, SDS3, RBBP4/RBAP48, RBBP7/RBAP46, SAP30, and SAP18. SIN3 proteins contain four paired amphipathic alpha-helix (PAH) motifs that function in the recruitment of the SIN3 complex to target genes by binding a multitude of D-binding transcriptiol repressor proteins, including Mad1, p53, E2F4, HCF-1, AML1, Elk-1, NRSF, CTCF, ERa, and MeCP2. In addition, SIN3 proteins contain an HDAC interaction domain (HID), which mediates binding of HDAC1 and HDAC2 via the SDS3 bridging protein, and a highly conserved region (HCR) at the carboxy terminus, which contributes to repressor protein binding. RBBP4 and RBBP7 proteins also bind to SDS3 and contribute to nucleosome binding of the complex. The SIN3 complex functions to repress transcription, in part, by deacetylating histones at target gene promoters. In addition, recent studies have shown that SIN3 is recruited to the coding regions of repressed and active genes, where it deacetylates histones and suppresses spurious transcription by R polymerase II. In addition to histone deacetylase activity, the SIN3 complex associates with histone methyltransferase (ESET), histone demethylase (JARID1A/RBP2), ATP-dependent chromatin remodeling (SWI/SNF), methylcytosine dioxygese (TET1), and O-Glcc transferase (OGT) activities, all of which appear to contribute to the regulation of target genes. The SIN3 complex is critical for proper regulation of embryonic development, cell growth and proliferation, apoptosis, D replication, D repair, and D methylation (imprinting and X-chromosome ictivation)

General readings

Zhao,X., (2008) Genes Dev. 22 (5), 640-653

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SIN3A antibody

Western blot analysis of extracts of various cell lines, using SIN3A antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

SIN3A antibody

WB Suggested Anti-SIN3A Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Hela cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

SIN3A antibody

SIN3A Mouse IgG1 1B7 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SIN3A antibody

Human Placenta; Immunohistochemistry with Human Placenta lysate tissue at an antibody concentration of 5.0ug/ml using anti-SIN3A antibody (ARP32483_P050); SIN3A antibody - N-terminal region (ARP32483_P050) in Human Placenta cells using Immunohistochemistry Rabbit Aff - Purified Chk, Hu, Ms, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

CRISPR

Catalog No. Species Donor Vector  

SIN3A - human gene knockout kit via CRISPR

SIN3A - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SIN3A

SIN3A Human
2 µg / €300.00
  Abnova Taiwan Corp.

SIN3A

SIN3A Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

SIN3A

SIN3A Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

SIN3A

SIN3A Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

SIN3A

SIN3A Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SIN3A (mGFP-tagged) - Human SIN3 homolog A, transcription regulator (yeast) (SIN3A), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, SIN3A (mGFP-tagged) - Human SIN3 homolog A, transcription regulator (yeast) (SIN3A), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,320.00
  OriGene Technologies, Inc.

Lenti ORF particles, SIN3A (mGFP-tagged) - Human SIN3 homolog A, transcription regulator (yeast) (SIN3A), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, SIN3A (mGFP-tagged) - Human SIN3 homolog A, transcription regulator (yeast) (SIN3A), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,320.00
  OriGene Technologies, Inc.

Lenti ORF particles, SIN3A (mGFP-tagged) - Human SIN3 homolog A, transcription regulator (yeast) (SIN3A), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, SIN3A (mGFP-tagged) - Human SIN3 homolog A, transcription regulator (yeast) (SIN3A), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,320.00
  OriGene Technologies, Inc.

Lenti ORF particles, SIN3A (Myc-DDK tagged) - Human SIN3 homolog A, transcription regulator (yeast) (SIN3A), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, SIN3A (Myc-DDK tagged) - Human SIN3 homolog A, transcription regulator (yeast) (SIN3A), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €1,180.00
  OriGene Technologies, Inc.

Lenti ORF particles, SIN3A (Myc-DDK tagged) - Human SIN3 homolog A, transcription regulator (yeast) (SIN3A), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, SIN3A (Myc-DDK tagged) - Human SIN3 homolog A, transcription regulator (yeast) (SIN3A), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €1,180.00
  OriGene Technologies, Inc.

Lenti ORF particles, SIN3A (Myc-DDK tagged) - Human SIN3 homolog A, transcription regulator (yeast) (SIN3A), transcript variant 3 , 200 uL, >10^7 TU/mL

Lenti ORF particles, SIN3A (Myc-DDK tagged) - Human SIN3 homolog A, transcription regulator (yeast) (SIN3A), transcript variant 3 , 200 uL, >10^7 TU/mL  
200 µl / €1,180.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Sin3a (GFP-tagged) - Mouse transcriptional regulator, SIN3A (yeast) (cDNA clone MGC:64685 IMAGE:6837144), 200 uL, >10^7 TU/mL

Lenti ORF particles, Sin3a (GFP-tagged) - Mouse transcriptional regulator, SIN3A (yeast) (cDNA clone MGC:64685 IMAGE:6837144), 200 uL, >10^7 TU/mL  
200 µl / €1,780.00
  OriGene Technologies, Inc.

Lenti ORF particles, Sin3a (GFP-tagged) - Mouse transcriptional regulator, SIN3A (yeast) (Sin3a), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Sin3a (GFP-tagged) - Mouse transcriptional regulator, SIN3A (yeast) (Sin3a), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €2,140.00
  OriGene Technologies, Inc.

Lenti ORF particles, Sin3a (GFP-tagged) - Mouse transcriptional regulator, SIN3A (yeast) (Sin3a), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Sin3a (GFP-tagged) - Mouse transcriptional regulator, SIN3A (yeast) (Sin3a), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €2,140.00
  OriGene Technologies, Inc.

Lenti ORF particles, Sin3a (GFP-tagged) - Mouse transcriptional regulator, SIN3A (yeast) (Sin3a), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, Sin3a (GFP-tagged) - Mouse transcriptional regulator, SIN3A (yeast) (Sin3a), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €2,140.00
  OriGene Technologies, Inc.

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