SIP1 / GEMIN2 antibody

Principal name

SIP1 / GEMIN2 antibody

Alternative names for SIP1 / GEMIN2 antibody

GEMIN-2, Survival of motor neuron protein-interacting protein 1, SMN-interacting protein 1, Component of gems 2

SwissProt ID

O14893 (Human), O14893-2, O42260 (Xenla), Q9CQQ4 (Mouse), Q9QZP1 (Rat)

Gene ID

8487 (GEMIN2), 66603 (Sip1)

Available reactivities

Hu (Human), Bov (Bovine), Ms (Mouse), Rt (Rat), Xen (Xenopus), Can (Canine), Eq (Equine), Por (Porcine), Rb (Rabbit), GP (Guinea Pig), Ze (Zebrafish)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunoprecipitation (IP), Paraffin Sections (P), Flow Cytometry (F)

Background of SIP1 / GEMIN2 antibody

Smad Interacting Protein 1 (SIP1) is observed in neural crest derived cells (peripheric nervous system, enteric nervous system, facial neurectoderm and cranial nerve ganglia), central nervous system, genital tubercle, muscles and kidneys in the developing human. SIP1 belongs to the delta-EF1/Zfh1 family of 2-handed zinc finger/homeodomain proteins and contains a SMAD-binding domain, a homeodomain and two clusters of zinc fingers on the N- and C-termini. SIP1 can be induced by TGF. SIP1 plays a crucial role in normal embryonic development of neural structures and the neural crest. Mutations in the SIP1 gene cause a form of Hirschsprung disease (HSCR). Patients with SIP1 mutations show mental retardation, delayed motor development, epilepsy, microcephaly, distinct facial features and/or congenital heart disease. SIP1 is also involved in the regulation of epithelial to mesenchymal transition, an important process in tumor progression.

General readings

Gregory,P.A., (2008) Nat. Cell Biol. 10 (5), 593-601

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SIP1 / GEMIN2 antibody

Immunohistochemical staining of paraffin-embedded Human lymph node tissue within the normal limits using anti-GEMIN2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA808769)(1:150) Mouse IgG1 OTI4C11 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SIP1 / GEMIN2 (C-term) antibody

Western blot analysis of SIP1 in HeLa cell lysate with SIP1 antibody at (A) 0.5 and (B) 1ug/mL. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SIP1 / GEMIN2 antibody

Predicted cell location: Cytoplasm. Positive control: Human ovarian and breast cancer tissue . Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human ovarian cancer tissue using GEMIN2 antibody at dilution 1/25, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

SIP1 / GEMIN2 antibody

Predicted band size: 32 kDa . Positive control: K562 and hela cell lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lane1: K562 cell lysate Lane2: Hela cell lysate Lysates: 40 ug per lane Primary antibody: 1/400 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 2 minutes) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SIP1 / GEMIN2 antibody

Predicted cell location: Cytoplasm. Positive control: Human breast and gastric cancer tissue . Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human breast cancer tissue using GEMIN2 antibody at dilution 1/40, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

SIP1 / GEMIN2 antibody

Predicted cell location: Cytoplasm. Positive control: Human liver and ovarian cancer tissue . Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human liver cancer tissue using GEMIN2 antibody at dilution 1/40, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

SIP1 / GEMIN2 antibody

WB Suggested Anti-SIP1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Hela cell lysate.GEMIN2 is strongly supported by BioGPS gene expression data to be expressed in HeLa Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

SIP1 / GEMIN2 antibody

WB Suggested Anti-Sip1 Antibody; Titration: 1.0 ug/ml; Positive Control: Mouse Brain Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

SIP1 / GEMIN2 antibody

Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-GEMIN2 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA808759)(1:150) Mouse IgG1 OTI4B3 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SIP1 / GEMIN2 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SIP1 (RC211219, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SIP1.(1:2000) Mouse IgG1 OTI6G4 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SIP1 / GEMIN2 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SIP1 (RC211219, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SIP1.(1:2000) Mouse IgG1 OTI4A2 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SIP1 / GEMIN2 control peptide

SIP1 / GEMIN2
50 µg / €160.00
  Acris Antibodies GmbH

SIP1 / GEMIN2 (C-term) antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

SIP1 / GEMIN2 antibody

Immunofluorescence of purified MaxPab antibody to SIP1 on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

SIP1 / GEMIN2 antibody

SIP1 / GEMIN2 Mouse IgG1 2E17 Hu E, ICC/IF, IP, WB
0.1 ml / €560.00
  Abnova Taiwan Corp.

SIP1 / GEMIN2 antibody

Human 721_B; Host:Rabbit. Target Name:GEMIN2. Sample Tissue:Human 721_B. Antibody Dilution: 1.0ug/ml. GEMIN2 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells.; SIP1 antibody - middle region (ARP40272_P050) in Human 721_B cells using Western Blot Rabbit Aff - Purified Bov, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

SIP1 / GEMIN2 (N-term) antibody

Mouse Brain; WB Suggested Anti-Sip1 Antibody. . Titration: 1.0 ug/ml. . Positive Control: Mouse Brain; Sip1 antibody - N-terminal region (ARP40273_P050) in Mouse Brain cells using Western Blot Rabbit Aff - Purified Hu, Ms WB
50 µg / €350.00
  AVIVA Systems Biology

SIP1 / GEMIN2 antibody

Western blot analysis of Gemin2 expression in A549 (A); Raw264.7 (B); H9C2 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

SIP1 / GEMIN2 antibody

Western blot analysis of Gemin2 expression in A549 (A); Raw264.7 (B); H9C2 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

SIP1 / GEMIN2 antibody

Western blot analysis of Gemin2 expression in A549 (A); Raw264.7 (B); H9C2 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

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