SIRT6 antibody

Principal name

SIRT6 antibody

Alternative names for SIRT6 antibody

SIRT-6, SIR2-like protein 6, SIR2L6, sirtuin type 6, sirtuin 6, sirtuin-6, sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae), NAD-dependent deacetylase sirtuin-6

SwissProt ID

P59941 (Mouse), Q8N6T7 (Human), Q9NRC7 (Human)

Gene ID

51548 (SIRT6), 50721 (Sirt6)

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat), African clawed frog

Available hosts

Rabbit, Mouse, Chicken

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C)

Background of SIRT6 antibody

SIRT6 is a D-dependent protein deacetylase. SIRT6 has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. SIRT6 modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target D. SIRT6 may be required for the association of WRN with telomeres during S-phase and for normal telomere maintence. SIRT6 is required for genomic stability, normal IGF1 serum levels and normal glucose homeostasis. SIRT6 modulates cellular senescence and apoptosis. SIRT6 regulates the production of TNF protein.This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombition of rD. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.

General readings

Michishita E., et al. (2008) Nature. 27;452(7186):492-6.
Mostoslavsky R., et al. (2006) Cell. 27;124(2):315-29.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SIRT6 antibody

  SIRT6 mouse monoclonal antibody, clone OTI1G3 (formerly 1G3)  
Anti-SIRT6 mouse monoclonal antibody (TA503670) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SIRT6(RC202833). Mouse IgG1 OTI1G3 Purified Hu ICC/IF, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

SIRT6 antibody

  Rabbit Polyclonal Antibody against SIRT6  
Detection of SIRT6 in HeLa whole cell lysate Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SIRT6 antibody

  Rabbit Polyclonal Antibody against SIRT6  
Detection of SIRT6 in HeLa whole cell lysate Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SIRT6 (C-term) antibody

  Chicken Polyclonal SIRT6 Antibody  
Western blot analysis of SIRT6 in HeLa cell lysate with SIRT6 antibody at (A) 0.5 and (B) 1 ug/mL. Chicken Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SIRT6 antibody

  Anti-SIRT6 Rabbit Polyclonal Antibody  
Predicted band size: 39 kDa . Positive control: Mouse stomach tissue lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/300 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 5 seconds) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SIRT6 antibody

  Rabbit Polyclonal Anti-SIRT6 Antibody  
WB Suggested Anti-SIRT6 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human Spleen Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

SIRT6 antibody

  Rabbit Polyclonal Anti-SIRT6 Antibody  
WB Suggested Anti-SIRT6 Antibody Titration: 1.25ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SIRT6 antibody

  Rabbit Polyclonal SIRT6 Antibody  
Western Blot: SIRT6 Antibody [TA336289] - WB analysis of SIRT6 in NIH/3T3 cell lysate. Rabbit Purified Ms C, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SIRT6 antibody

  Mouse Monoclonal SIRT6 Antibody  
Western blot analysis of extracts from CHO-K1 cells,transfected with pcDNA3.1-FLAG vector (A) or transfected with pcDNA3.1-FLAG-SIRT6 construct (B),using SIRT6 mouse mAb (1:500 diluted). Mouse IgG1 1B5-G10-H9 Purified WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SIRT6 (305-320) antibody

Figure 1. Staining SIRT6 in Adrenal by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Purified Hu E, P
50 µg / €470.00
  Acris Antibodies GmbH

SIRT6 (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

SIRT6 - human gene knockout kit via CRISPR

SIRT6 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

SIRT6 - human gene knockout kit via CRISPR

SIRT6 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

SIRT6 - human gene knockout kit via CRISPR

SIRT6 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

SIRT6 - human gene knockout kit via CRISPR

SIRT6 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Sirt6 - mouse gene knockout kit via CRISPR

Sirt6 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Sirt6 - mouse gene knockout kit via CRISPR

Sirt6 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Sirt6 - mouse gene knockout kit via CRISPR

Sirt6 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Sirt6 - mouse gene knockout kit via CRISPR

Sirt6 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SIRT6

  Recombinant protein of human sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) (SIRT6)  
SIRT6 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

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