SIRT6 antibody

Principal name

SIRT6 antibody

Alternative names for SIRT6 antibody

SIRT-6, SIR2-like protein 6, SIR2L6, sirtuin type 6, sirtuin 6, sirtuin-6, sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae), NAD-dependent deacetylase sirtuin-6

SwissProt ID

P59941 (Mouse), Q8N6T7 (Human), Q9NRC7 (Human)

Gene ID

51548 (SIRT6), 50721 (Sirt6)

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat), African clawed frog

Available hosts

Rabbit, Mouse, Chicken

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C)

Background of SIRT6 antibody

SIRT6 is a D-dependent protein deacetylase. SIRT6 has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. SIRT6 modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target D. SIRT6 may be required for the association of WRN with telomeres during S-phase and for normal telomere maintence. SIRT6 is required for genomic stability, normal IGF1 serum levels and normal glucose homeostasis. SIRT6 modulates cellular senescence and apoptosis. SIRT6 regulates the production of TNF protein.This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombition of rD. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.

General readings

Michishita E., et al. (2008) Nature. 27;452(7186):492-6.
Mostoslavsky R., et al. (2006) Cell. 27;124(2):315-29.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SIRT6 antibody

Anti-SIRT6 mouse monoclonal antibody (TA503670) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SIRT6(RC202833). Mouse IgG1 OTI1G3 Purified Hu ICC/IF, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

SIRT6 antibody

Detection of SIRT6 in HeLa whole cell lysate Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SIRT6 antibody

Detection of SIRT6 in HeLa whole cell lysate Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SIRT6 (C-term) antibody

Western blot analysis of SIRT6 in HeLa cell lysate with SIRT6 antibody at (A) 0.5 and (B) 1 ug/mL. Chicken Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SIRT6 antibody

Predicted band size: 39 kDa . Positive control: Mouse stomach tissue lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/300 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 5 seconds) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SIRT6 antibody

WB Suggested Anti-SIRT6 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human Spleen Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

SIRT6 antibody

WB Suggested Anti-SIRT6 Antibody Titration: 1.25ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SIRT6 antibody

Western Blot: SIRT6 Antibody [TA336289] - WB analysis of SIRT6 in NIH/3T3 cell lysate. Rabbit Purified Ms C, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SIRT6 antibody

Western blot analysis of extracts from CHO-K1 cells,transfected with pcDNA3.1-FLAG vector (A) or transfected with pcDNA3.1-FLAG-SIRT6 construct (B),using SIRT6 mouse mAb (1:500 diluted). Mouse IgG1 1B5-G10-H9 Purified WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SIRT6 (305-320) antibody

Figure 1. Staining SIRT6 in Adrenal by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Purified Hu E, P
50 µg / €470.00
  Acris Antibodies GmbH

SIRT6 (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P
0.4 ml / €370.00
  Acris Antibodies GmbH

SIRT6 control peptide

SIRT6
50 µg / €160.00
  Acris Antibodies GmbH

SIRT6 (56-105) antibody

Formalin-Fixed, Paraffin-Embedded Human Testis stained with SIRT6 Antibody Cat.-No AP31324PU-N at 10 µg/ml after heat-induced antigen retrieval. Rabbit IgG Purified Av, Bov, Bt, Can, Eq, GP, Hst, Hu, Mky, Ms, Op, Prim, Rt, Xen P, WB
0.1 mg / €530.00
  Acris Antibodies GmbH

SIRT6 antibody

Western Blot analysis of SIRT6 expression in transfected 293T cell line (H00051548-T02) by SIRT6 MaxPab polyclonal antibody.

Lane 1: SIRT6 transfected lysate(36.08 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

SIRT6 antibody

SIRT6 Mouse IgG2a 1D8 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

SIRT6 antibody

Formalin-fixed and paraffin-embedded human breast cancer tissue reacted with SIRT6 polyclonal antibody ( Cat # PAB1985 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Hu, Ms E, P
0.4 ml / €390.00
  Abnova Taiwan Corp.

SIRT6 antibody

Western blot analysis of Sirt6 in MEF lysate with Sirt6 polyclonal antibody ( Cat# PAB12035 ). Rabbit Ms WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

SIRT6 antibody

Western blot analysis of SIRT6 in HeLa whole cell lysate with SIRT6 polyclonal antibody ( Cat # PAB12036 ). Rabbit Hu WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

SIRT6 antibody

Western blot analysis of SIRT6 in HeLa whole cell lysate with SIRT6 polyclonal antibody ( Cat# PAB12037 ). Rabbit Hu WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

SIRT6 antibody

Human U2OS; U2OS; SIRT6 antibody - middle region (ARP32408_P050) in Human U2OS cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

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