SKA1 antibody

Principal name

SKA1 antibody

Alternative names for SKA1 antibody

C18orf24, Spindle and kinetochore-associated protein 1

SwissProt ID

Q6DHG8 (Danre), Q96BD8 (Human), Q9CPV1 (Mouse)

Gene ID

220134 (SKA1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of SKA1 antibody

Upon entry into mitosis, the cell’s microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes. Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs. A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, has been found to be required for stable KT-MT interactions and timely anaphase onset. Depletion of either SKA1 or SKA2 by siRNA results in the loss of both proteins from the KT, but does not impact overall KT structure. Cells depleted of the SKA complex undergo a prolonged checkpoint-dependent delay in a metaphase-like state, indicating the importance of the SKA complex in the maintenance of the metaphase plate and spindle checkpoint silencing.

General readings

Ota T. et al. (2004) Nat Genet. 36:40-45
Hanisch A. et al. (2006) EMBO J. 25: 5504-5515.

10 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SKA1 antibody

Western blot analysis of SKA1 in A549 cell lysate with SKA1 antibody at (A) 0.5 and (B) 1 µg/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SKA1 (C-term) antibody

Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

SKA1 Control Peptide

SKA1
50 µg / €160.00
  Acris Antibodies GmbH

SKA1 antibody

SKA1 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

SKA1 antibody

SKA1 Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €480.00
  Novus Biologicals Inc.

SKA1 antibody

Immunohistochemistry-Paraffin: SKA1 Antibody [NBP1-92391] - Immunohistochemical staining of human small intestine shows distinct cytoplasmic and membranous positivity in glandular cells. Rabbit IgG Aff - Purified Hu ICC/IF, P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SKA1 (transcript variant 2)

SKA1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

SKA1 (transcript variant 1)

SKA1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

SKA1 (1-255, His-tag)

SKA1 Human Purified > 80 % by SDS - PAGE E. coli
50 µg / €730.00
  Acris Antibodies GmbH

SKA1 (1-255, His-tag)

SKA1 Human Purified > 80 % by SDS - PAGE E. coli
10 µg / €300.00
  Acris Antibodies GmbH

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