SKA2 antibody

Principal name

SKA2 antibody

Alternative names for SKA2 antibody

FAM33A, Spindle and kinetochore-associated protein 2

SwissProt ID

Q2TBY0 (Bovin), Q5I0J4 (Rat), Q8WVK7 (Human), Q9CR46 (Mouse)

Gene ID

348235 (SKA2)

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C)

Background of SKA2 antibody

Upon entry into mitosis, the cell's microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes. Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs. A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, has been found to be required for stable KT-MT interactions and timely anaphase onset. Depletion of either SKA1 or SKA2 by siRNA results in the loss of both proteins from the KT, but does not impact overall KT structure. Cells depleted of the SKA complex undergo a prolonged checkpoint-dependent delay in a metaphase-like state, indicating the importance of the SKA complex in the maintenance of the metaphase plate and spindle checkpoint silencing. SKA2 has also been shown to interact with glucocorticoid receptors and to be involved in glucocorticoid signaling and cell proliferation.

6 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SKA2 antibody

Western blot analysis of SKA2 in 3T3 cell lysate with SKA2 antibody at (A) 0.5 and (B) 1 µg/ml. Rabbit IgG Aff - Purified Hu, Ms E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SKA2 (N-term) antibody

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu, Ms E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

SKA2 Control Peptide

SKA2
50 µg / €160.00
  Acris Antibodies GmbH

SKA2 (N-term) antibody

Formalin fixed, paraffin embedded human cervix tissue stained with SKA2 Antibody (N-term) Cat.-No AP53923PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of SKA2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

SKA2 antibody

SKA2 Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

SKA2 antibody

Western Blot: SKA2 Antibody [NBP1-76312] - Analysis of SKA2 in 3T3 cell lysate with SKA2 antibody at (A) 0.5 and (B) 1 ug/mL._x000d_ Rabbit Aff - Purified Hu, Ms E, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

6 Item(s)

per page
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