Skeletal muscle Troponin T antibody

Principal name

Skeletal muscle Troponin T antibody

Alternative names for Skeletal muscle Troponin T antibody

TnTs, TNNT1, TNT

SwissProt ID

O88346 (Mouse), P13805 (Human), Q75ZZ6 (Pig), Q7TNB2 (Rat), Q8MKH6 (Bovin)

Gene ID

7138 (TNNT1), 21955 (Tnnt1), 171409

Available reactivities

Hu (Human), Bov (Bovine), Chk (Chicken), Ms (Mouse), Por (Porcine), Rt (Rat), Ze (Zebrafish), African clawed frog, Rb (Rabbit), Can (Canine), Eq (Equine), GP (Guinea Pig)

Available hosts

Mouse, Rabbit, Goat

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Frozen Sections (C), Immunoprecipitation (IP), Paraffin Sections (P)

Background of Skeletal muscle Troponin T antibody

TNNT1 is a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year.This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene.

General readings

Witt,S.H., (2005) J. Mol. Biol. 350 (4), 713-722

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Skeletal muscle Troponin T antibody

  Rabbit Polyclonal Anti-TNNT1 Antibody  
WB Suggested Anti-TNNT1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Human Muscle Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Skeletal muscle Troponin T antibody

Skeletal muscle Troponin T Mouse IgG1 TT-98 Purified Chk, Hu, Ms, Rb, Rt C, IP, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Skeletal muscle Troponin T antibody

AP33501PU-N (0.03µg/ml) staining of Human Skeletal Muscle lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Por WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

TNNT1 - human gene knockout kit via CRISPR

TNNT1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

TNNT1 - human gene knockout kit via CRISPR

TNNT1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

TNNT1 - human gene knockout kit via CRISPR

TNNT1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

TNNT1 - human gene knockout kit via CRISPR

TNNT1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tnnt1 - mouse gene knockout kit via CRISPR

Tnnt1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Tnnt1 - mouse gene knockout kit via CRISPR

Tnnt1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tnnt1 - mouse gene knockout kit via CRISPR

Tnnt1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tnnt1 - mouse gene knockout kit via CRISPR

Tnnt1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Skeletal muscle Troponin T (transcript variant 1)

  Recombinant protein of human troponin T type 1 (skeletal, slow) (TNNT1), transcript variant 1  
Skeletal muscle Troponin T Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Skeletal muscle Troponin T (full length, C-term DDK tag, transcript variant 1)

  Purified recombinant protein of Human troponin T type 1 (skeletal, slow) (TNNT1), transcript variant 1, full length, with C-terminal DDK tag, expressed in sf9, 20ug  
Skeletal muscle Troponin T Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
SF9 cells
20 µg / €399.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

TNNT1 overexpression lysate

TNNT1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

TNNT1 overexpression lysate

TNNT1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, TNNT1 (mGFP-tagged) - Human troponin T type 1 (skeletal, slow) (TNNT1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, TNNT1 (mGFP-tagged) - Human troponin T type 1 (skeletal, slow) (TNNT1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, TNNT1 (mGFP-tagged) - Human troponin T type 1 (skeletal, slow) (TNNT1), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, TNNT1 (mGFP-tagged) - Human troponin T type 1 (skeletal, slow) (TNNT1), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, TNNT1 (Myc-DDK tagged) - Human troponin T type 1 (skeletal, slow) (TNNT1), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, TNNT1 (Myc-DDK tagged) - Human troponin T type 1 (skeletal, slow) (TNNT1), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €860.00
  OriGene Technologies, Inc.

Lenti ORF particles, TNNT1 (Myc-DDK tagged) - Human troponin T type 1 (skeletal, slow) (TNNT1), transcript variant 3 , 200 uL, >10^7 TU/mL

Lenti ORF particles, TNNT1 (Myc-DDK tagged) - Human troponin T type 1 (skeletal, slow) (TNNT1), transcript variant 3 , 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Tnnt1 (GFP-tagged) - Mouse troponin T1, skeletal, slow (Tnnt1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Tnnt1 (GFP-tagged) - Mouse troponin T1, skeletal, slow (Tnnt1), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

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