SLC12A3 antibody

Principal name

SLC12A3 antibody

Alternative names for SLC12A3 antibody

TSC, Solute carrier family 12 member 3, Thiazide-sensitive sodium-chloride cotransporter, Na-Cl symporter

SwissProt ID

P55017 (Human), P55018 (Rat), P59158 (Mouse)

Gene ID

6559 (SLC12A3), 54300 (Slc12a3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of SLC12A3 antibody

Na-K-Cl cotransporters (NKCC) are channel proteins that aid in the transcellular movement of chloride across both secretory and absorptive epithelia. NKCC1 is expressed in muscle cells, neurons, and red blood cells. In the basolateral membrane of secretory epithelia, NKCC1 mediates active chloride secretion. The gene encoding human NKCC1 maps to chromosome 5q23.3. In mice, disruption of the NKCC1 gene leads to deafness and impaired balance. NKCC2 is specifically expressed in the kidney where it mediates active reabsorption of sodium chloride in the thick ascending limb of the loop of Henle. NKCC2 is sensitive to the clinically important diuretics furosemide and bumetanide. The gene encoding human NKCC2 maps to chromosome 15q15-q21 and mutations in this gene lead to Bartter’s syndrome, an inherited hypokalaemic alkalosis. NCCT is a thiazide-sensitive Na-Cl cotransporter that is primarily expressed in the distal convoluted tubule of the kidney where it accounts for a significant fraction of net renal sodium reabsorption. The gene for human NCCT map to chromosome 16q13. Mutations in the gene encoding NCCT cause Gitelman’s syndrome, a subset of Bartter’s syndrome.

9 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SLC12A3 antibody

Western blot analysis of NCC in rat tissues using a 1:1000 dilution of the antibody Rabbit Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SLC12A3 antibody

WB Suggested Anti-SLC12A3 Antibody Titration: 0.2-1 ug/ml; Positive Control: ACHN cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

SLC12A3 antibody

SLC12A3 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

SLC12A3 antibody

Human ACHN; WB Suggested Anti-SLC12A3 Antibody Titration: 0.2-1 ug/ml. Positive Control: ACHN cell lysate; SLC12A3 antibody - middle region (ARP43742_P050) in Human ACHN cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

SLC12A3 antibody

SLC12A3 Rabbit Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €450.00
  Novus Biologicals Inc.

SLC12A3 antibody

Western Blot: SLC12A3 Antibody [NBP1-59699] - This Anti-SLC12A3 antibody was used in Western Blot of ACHN       tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

SLC12A3 antibody

Immunohistochemistry-Paraffin: SLC12A3 Antibody [NBP1-86376] Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in cells in tubules. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SLC12A3 (transcript variant 1)

SLC12A3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

SLC12A3 overexpression lysate

SLC12A3 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

9 Item(s)

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