SLC12A4 antibody

Principal name

SLC12A4 antibody

Alternative names for SLC12A4 antibody

KCC1, Solute carrier family 12 member 4, Erythroid K-Cl cotransporter 1

SwissProt ID

Q28677 (Rabit), Q63632 (Rat), Q9JIS8 (Mouse), Q9UP95 (Human)

Gene ID

6560 (SLC12A4), 29501 (Slc12a4), 20498

Available reactivities

Hu (Human), Bt (Bat), Bov (Bovine), Can (Canine), Eq (Equine), Hst (Hamster), Mky (Monkey), Ms (Mouse), Prim (Primate), Rb (Rabbit), Rt (Rat), Bear, GP (Guinea Pig), Sh (Sheep)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of SLC12A4 antibody

Potassium chloride cotransporters (KCCs) are members of cation chloride cotransporter gene superfamily (Slc12 family). This family consists of sodium potassium two chloride cotransporter 1 (NKCC1) and 2 (NKCC2), sodium chloride cotransporte (NCC) and KCCs. All of these transporters mediate electroneutral transport of cations coupled with one or two Cl and contribute to regulation of cell volume and homeostasis of intracellular Cl concentration. KCCs extrude one K+ with one Cl from intracellular space to the extracellular space by using the chemical gradient of K+ as the driving force of Cl extrusion. Four KCC isofroms (KCC1, KCC2, KCC3 and KCC4) have been identified in mammalian species . K-Cl cotransporters regulate neurol and glial electrochemical equilibrium potential for Cl, and so can determine the excitatory or inhibitory influences of GABA- and glycine-gated Cl channels. KCC1 is a member of the cation-chloride cotransporter (CCC) superfamily of proteins, as with all CCC proteins, KCC1 is an integral membrane protein with 12 transmembrane domains and both N- and C-termil cytoplasmic domains. KCC1 is ubiquitously expressed. K-Cl cotransport activity is elevated in red blood cells of individuals with sickle cell disease, thalassemia, and diseases associated with other mutant Hb. Human erythrocytes from individuals with the reticulocytotic anemic states of sickle cell disease, Hb SC disease, and β-thalassemia intermedia exhibit uniformly elevated KCC1-like immunoreactivity compared with normal AA erythrocytes .

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SLC12A4 antibody

  Goat Polyclonal Antibody against SLC12A4  
TA303291 (0.3µg/ml) staining of Human Heart lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SLC12A4 antibody

  Anti-SLC12A4 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm . Positive control: Human thyroid and colon cancer tissue . Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using SLC12A4 antibody at dilution 1/30, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

SLC12A4 antibody

  Anti-SLC12A4 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm . Positive control: Human brain and thyroid cancer tissue . Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human brain tissue using SLC12A4 antibody at dilution 1/30, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

SLC12A4 antibody

  Rabbit Polyclonal Anti-KCC1  
Western blot analysis of rat brain membranes (lanes 1 and 4), mouse brain membranes (lanes 2 and 5) and human K562 erythroleukemia cell lysates (lanes 3 and 6): 1-3. Anti-KCC1 antibody, (1:200). 4-6. Anti-KCC1 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

SLC12A4 antibody

  Rabbit Polyclonal Anti-SLC12A4 Antibody  
WB Suggested Anti-SLC12A4 Antibody Titration: 0.2-1 ug/ml; Positive Control: PANC1 cell lysate;There is BioGPS gene expression data showing that SLC12A4 is expressed in PANC1 Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

SLC12A4 (997-1007) antibody

AP08770PU-N at 5 µg/ml staining of SLC12A4 in Human Placenta tissue by Immunohistochemistry (FFPE) Goat IgG Aff - Purified Bear, Bov, Bt, Can, Elephant, Eq, Hst, Hu, Mky, Ms, Prim, Rb, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

SLC12A4 - human gene knockout kit via CRISPR

SLC12A4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

SLC12A4 - human gene knockout kit via CRISPR

SLC12A4 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

SLC12A4 - human gene knockout kit via CRISPR

SLC12A4 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

SLC12A4 - human gene knockout kit via CRISPR

SLC12A4 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Slc12a4 - mouse gene knockout kit via CRISPR

Slc12a4 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Slc12a4 - mouse gene knockout kit via CRISPR

Slc12a4 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Slc12a4 - mouse gene knockout kit via CRISPR

Slc12a4 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Slc12a4 - mouse gene knockout kit via CRISPR

Slc12a4 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates (Knockout)

Catalog No.    

SLC12A4-knockout Cell lysate

SLC12A4-knockout Cell lysate  
0.1 mg / €495.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SLC12A4 (mGFP-tagged) - Human solute carrier family 12 (potassium/chloride transporters), member 4 (SLC12A4), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, SLC12A4 (mGFP-tagged) - Human solute carrier family 12 (potassium/chloride transporters), member 4 (SLC12A4), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,320.00
  OriGene Technologies, Inc.

Lenti ORF particles, SLC12A4 (mGFP-tagged)-Human solute carrier family 12 (potassium/chloride transporters), member 4 (SLC12A4), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, SLC12A4 (mGFP-tagged)-Human solute carrier family 12 (potassium/chloride transporters), member 4 (SLC12A4), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €2,160.00
  OriGene Technologies, Inc.

Lenti ORF particles, SLC12A4 (mGFP-tagged)-Human solute carrier family 12 (potassium/chloride transporters), member 4 (SLC12A4), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, SLC12A4 (mGFP-tagged)-Human solute carrier family 12 (potassium/chloride transporters), member 4 (SLC12A4), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €2,180.00
  OriGene Technologies, Inc.

Lenti ORF particles, SLC12A4 (mGFP-tagged)-Human solute carrier family 12 (potassium/chloride transporters), member 4 (SLC12A4), transcript variant 4, 200 uL, >10^7 TU/mL

Lenti ORF particles, SLC12A4 (mGFP-tagged)-Human solute carrier family 12 (potassium/chloride transporters), member 4 (SLC12A4), transcript variant 4, 200 uL, >10^7 TU/mL  
200 µl / €2,160.00
  OriGene Technologies, Inc.

Lenti ORF particles, SLC12A4 (mGFP-tagged)-Human solute carrier family 12 (potassium/chloride transporters), member 4 (SLC12A4), transcript variant 5, 200 uL, >10^7 TU/mL

Lenti ORF particles, SLC12A4 (mGFP-tagged)-Human solute carrier family 12 (potassium/chloride transporters), member 4 (SLC12A4), transcript variant 5, 200 uL, >10^7 TU/mL  
200 µl / €2,130.00
  OriGene Technologies, Inc.

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