SLC1A1 antibody

Principal name

SLC1A1 antibody

Alternative names for SLC1A1 antibody

EAAC1, EAAT3, EAAC-1, EAAT-3, Excitatory amino acid transporter 3, Sodium-dependent glutamate/aspartate transporter 3, Excitatory amino-acid carrier 1, Neuronal and epithelial glutamate transporter, Solute carrier family 1 member 1

SwissProt ID

P31597 (Rabit), P43005 (Human), P51906 (Mouse), P51907 (Rat)

Gene ID

6505 (SLC1A1), 20510 (Slc1a1), 25550

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Rb (Rabbit), African clawed frog, Xen (Xenopus), Mky (Monkey)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Immunoprecipitation (IP)

Background of SLC1A1 antibody

L-Glutamate (Glu) is an abundant amino acid that functions as the major excitatory neurotransmitter in the central nervous system. However, excess of Glu in the extracellular syptic milieu leads to neurol cell death by a process known as excitotoxicity. The extracellular levels of Glu are regulated by a family of high affinity plasma membrane transporters called excitatory amino acid transporters (EAATs) which are responsible for the re-uptake of Glu into the cells. The EAAT family includes five members (EAAT1-EAAT5) that are members of the solute carrier family 1 (SLC1) of +-dependent transporters that also includes the neutral amino acid transporters ASCT1 and ASCT2. The Glu transporters present an unusual topology of eight transmembrane domains with two re-entrant loops and intracellular N- and C- termini. The transporter is likely assembled as a trimer where each monomer is a functiol unit capable of binding the Glu substrate. The transport of Glu into the cells by the EAAT transporters is coupled to the + and K+ electrochemical gradient as a driving force. Hence, the uptake of Glu is dependent on the co-transport of three + and one H+ ions, and the counter transport of one K+ ion. In addition, to the well documented Glu uptake, the EAAT transporters show a Glu-independent Cl conductance. The physiological significance of the Cl current through the EAATs is currently unknown. EAAT2 as well as EAAT1 are expressed predomintly in glia cells, while EAAT3 (Excitatory Amino Acid Transporter 3), EAAT4 and EAAT5 are mostly expressed in neurons. As mentioned, EAAT transporters represent the only (significant) mechanism for removal of glutamate from the extracellular fluid and hence are essential for the long-term maintence of low and non-toxic concentrations of glutamate and the preservation of normal excitatory syptic transmission. In addition to Glu uptake, the glutamate transporters provide glutamate for the synthesis of g-Aminobutyric acid (GABA), glutathione and protein, suggesting an interactive role between EAATs and cellular metabolism. Dysregulation of EAAT activities has been implicated in several neurodegenerative disorders such as Alzheimerâ??s disease, traumatic brain injury, epilepsy and schizophrenia, suggesting that EAATs can be a useful target for the treatment of these conditions.

17 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SLC1A1 antibody

Western blot analysis of EAAC1 in rat brain membrane tissues, using a 1:1000 dilution of the antibody Mouse IgG1 S180-41 Purified Hu IP
0.1 mg / €325.00
  OriGene Technologies, Inc.

SLC1A1 antibody

Western blot analysis of rat brain membranes: 1. Anti-Excitatory Amino Acid Transporter 3 antibody, (1:400). 2. Anti-Excitatory Amino Acid Transporter 3 antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

SLC1A1 antibody

WB Suggested Anti-SLC1A1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: 721_B cell lysate;SLC1A1 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells Rabbit IgG Purified Bov, Can, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

SLC1A1 antibody

WB Suggested Anti-SLC1A1 Antibody Titration: 0.2-1 ug/ml; Positive Control: PANC1 cell lysate Rabbit IgG Purified Can, Hu, Ms, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

SLC1A1 antibody

Transfected cell immunoblot: extracts of COS cells transiently transfected with untagged EAAC1 or Kv2.1 plasmid and probed with N180/41 (left) and K89/34 (right) TC supe. Mouse IgG1 N180/41 Supernatant Hu ICC/IF, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

SLC1A1 antibody

Transfected cell immunoblot: extracts of COS cells transiently transfected with untagged EAAC1 or Kv2.1 plasmid and probed with N180/41 (left) and K89/34 (right) TC supe. Mouse IgG1 N180/41 Purified Hu ICC/IF, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

SLC1A1 antibody

Human 721_B; WB Suggested Anti-SLC1A1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: 721_B cell lysate. SLC1A1 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells.; SLC1A1 antibody - N-terminal region (ARP43865_P050) in Human 721_B cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Hu, Ms, Por, Rb, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

SLC1A1 antibody

Human PANC1; WB Suggested Anti-SLC1A1 Antibody Titration: 0.2-1 ug/ml. Positive Control: PANC1 cell lysate; SLC1A1 antibody - N-terminal region (ARP43866_P050) in Human PANC1 cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

SLC1A1 antibody

Western blot analysis of EAAT3 expression in PANC1 (A); HeLa (B); human testis (C) whole cell lysates. Rabbit Aff - Purified Hu, Mky, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

SLC1A1 antibody

Western blot analysis of EAAT3 expression in PANC1 (A); HeLa (B); human testis (C) whole cell lysates. Rabbit Aff - Purified Hu, Mky, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

SLC1A1 antibody

Western blot analysis of EAAT3 expression in PANC1 (A); HeLa (B); human testis (C) whole cell lysates. Rabbit Aff - Purified Hu, Mky, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

SLC1A1 antibody

Western Blot: EAAT3 Antibody [NBP1-59880] - This Anti-SLC1A1 antibody was used in Western Blot of PANC1       tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

SLC1A1 antibody

Western Blot: EAAT3 Antibody [NBP1-62519] - This Anti-SLC1A1 antibody was used in Western Blot of 721_B tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Bov, Can, Hu, Ms, Por, Rb, Rt, Xen WB
50 µg / €440.00
  Novus Biologicals Inc.

SLC1A1 antibody

Immunohistochemistry-Paraffin: EAAT3 Antibody (EPR6774(B)) [NBP1-95921] human kidney tissue using anti-EAAT3. Rabbit EPR6774(B) Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SLC1A1

SLC1A1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

SLC1A1

SLC1A1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

SLC1A1 overexpression lysate

SLC1A1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

17 Item(s)

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