SLC1A2 / EAAT2 antibody

Principal name

SLC1A2 / EAAT2 antibody

Alternative names for SLC1A2 / EAAT2 antibody

GLT1, Solute carrier family 1 member 2, Excitatory amino acid transporter 2, Sodium-dependent glutamate/aspartate transporter 2, Glutamate/aspartate transporter II

SwissProt ID

P31596 (Rat), P43004 (Human), P43006 (Mouse)

Gene ID

6506 (SLC1A2), 29482 (Slc1a2), 20511

Available reactivities

Hu (Human), Can (Canine), Chk (Chicken), Ms (Mouse), Rt (Rat), Ze (Zebrafish), Bov (Bovine), Eq (Equine), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Frozen Sections (C), Paraffin Sections (P)

Background of SLC1A2 / EAAT2 antibody

L-Glutamate (Glu) is an abundant amino acid that functions as the major excitatory neurotransmitter in the central nervous system. However, excess of Glu in the extracellular syptic milieu leads to neurol cell death by a process known as excitotoxicity. The extracellular levels of Glu are regulated by a family of high affinity plasma membrane transporters called excitatory amino acid transporters (EAATs) which are responsible for the re-uptake of Glu into the cells. The EAAT family includes five members (EAAT1-EAAT5) that are members of the solute carrier family 1 (SLC1) of +-dependent transporters that also includes the neutral amino acid transporters ASCT1 and ASCT2. The Glu transporters present an unusual topology of eight transmembrane domains with two re-entrant loops and intracellular N- and C- termini. The transporter is likely assembled as a trimer where each monomer is a functiol unit capable of binding the Glu substrate. The transport of Glu into the cells by the EAAT transporters is coupled to the + and K+ electrochemical gradient as a driving force. Hence, the uptake of Glu is dependent on the co-transport of three + and one H+ ions, and the counter transport of one K+ ion. In addition, to the well documented Glu uptake, the EAAT transporters show a Glu-independent Cl conductance. The physiological significance of the Cl current through the EAATs is currently unknown. EAAT2 (also known as Glutamate Transporter-1, GLT-1) as well as EAAT1, is expressed predomintly in glia cells, while EAAT3, EAAT4 and EAAT5 are mostly expressed in neurons. As mentioned earlier, EAAT transporters represent the only (significant) mechanism for removal of glutamate from the extracellular fluid and hence are essential for the long-term maintence of low and non-toxic concentrations of glutamate and the preservation of normal excitatory syptic transmission. In addition to Glu uptake, the glutamate transporters provide glutamate for the synthesis of g-Aminobutyric acid (GABA), glutathione and protein, suggesting an interactive role between EAATs and cellular metabolism. Dysregulation of EAAT activities has been implicated in several neurodegenerative disorders such as Alzheimerâ??s disease, traumatic brain injury, epilepsy and schizophrenia, suggesting that EAATs can be a useful target for the treatment of these conditions.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SLC1A2 / EAAT2 antibody

Immunoreactivity of this antibody on protein extract from rat (lane1) and mouse brain (lane2).
GLT1 protein is detected at 35 kDa and 70 kDa as dimmer
In lane 3, inhibition of the immunoreactivity of the Ab with blocking peptide (1/1000 dilution) Rabbit Serum Rt C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

SLC1A2 / EAAT2 antibody

  Rabbit Polyclonal Anti-SLC1A2 Antibody  
WB Suggested Anti-SLC1A2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human brain Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

SLC1A2 / EAAT2 antibody

  Anti-SLC1A2 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm, Cell membrane. Positive control: Human brain and liver cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using SLC1A2 antibody at dilution 1/20, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

SLC1A2 / EAAT2 antibody

  Rabbit Polyclonal Anti-Excitatory Amino Acid Transporter 2 (extracellular)  
Western blot analysis of rat cerebellum lysate: 1. Anti-Excitatory Amino Acid Transporter 2 (extracellular) antibody, (1:500). 2. Anti-Excitatory Amino Acid Transporter 2 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

SLC1A2 / EAAT2 antibody

  Rabbit Polyclonal Anti-SLC1A2 Antibody  
WB Suggested Anti-SLC1A2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:12500; Positive Control: HT1080 cell lysate Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

Slc1a2 - mouse gene knockout kit via CRISPR

Slc1a2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Slc1a2 - mouse gene knockout kit via CRISPR

Slc1a2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Slc1a2 - mouse gene knockout kit via CRISPR

Slc1a2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Slc1a2 - mouse gene knockout kit via CRISPR

Slc1a2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SLC1A2 (mGFP-tagged)-Human solute carrier family 1 (glial high affinity glutamate transporter), member 2 (SLC1A2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, SLC1A2 (mGFP-tagged)-Human solute carrier family 1 (glial high affinity glutamate transporter), member 2 (SLC1A2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, SLC1A2 (Myc-DDK-tagged)-Human solute carrier family 1 (glial high affinity glutamate transporter), member 2 (SLC1A2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, SLC1A2 (Myc-DDK-tagged)-Human solute carrier family 1 (glial high affinity glutamate transporter), member 2 (SLC1A2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Slc1a2 (GFP-tagged) - Mouse solute carrier family 1 (glial high affinity glutamate transporter), member 2 (Slc1a2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Slc1a2 (GFP-tagged) - Mouse solute carrier family 1 (glial high affinity glutamate transporter), member 2 (Slc1a2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,220.00
  OriGene Technologies, Inc.

Lenti ORF particles, Slc1a2 (GFP-tagged) - Mouse solute carrier family 1 (glial high affinity glutamate transporter), member 2 (Slc1a2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Slc1a2 (GFP-tagged) - Mouse solute carrier family 1 (glial high affinity glutamate transporter), member 2 (Slc1a2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,210.00
  OriGene Technologies, Inc.

Lenti ORF particles, Slc1a2 (GFP-tagged) - Mouse solute carrier family 1 (glial high affinity glutamate transporter), member 2 (Slc1a2), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, Slc1a2 (GFP-tagged) - Mouse solute carrier family 1 (glial high affinity glutamate transporter), member 2 (Slc1a2), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,190.00
  OriGene Technologies, Inc.

Lenti ORF particles, Slc1a2 (Myc-DDK-tagged) - Mouse solute carrier family 1 (glial high affinity glutamate transporter), member 2 (Slc1a2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Slc1a2 (Myc-DDK-tagged) - Mouse solute carrier family 1 (glial high affinity glutamate transporter), member 2 (Slc1a2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,090.00
  OriGene Technologies, Inc.

Lenti ORF particles, Slc1a2 (Myc-DDK-tagged) - Mouse solute carrier family 1 (glial high affinity glutamate transporter), member 2 (Slc1a2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Slc1a2 (Myc-DDK-tagged) - Mouse solute carrier family 1 (glial high affinity glutamate transporter), member 2 (Slc1a2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,080.00
  OriGene Technologies, Inc.

Lenti ORF particles, Slc1a2 (Myc-DDK-tagged) - Mouse solute carrier family 1 (glial high affinity glutamate transporter), member 2 (Slc1a2), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, Slc1a2 (Myc-DDK-tagged) - Mouse solute carrier family 1 (glial high affinity glutamate transporter), member 2 (Slc1a2), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,070.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Slc1a2 (Myc-DDK-tagged ORF) - Rat solute carrier family 1 (glial high affinity glutamate transporter), member 2 (Slc1a2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Slc1a2 (Myc-DDK-tagged ORF) - Rat solute carrier family 1 (glial high affinity glutamate transporter), member 2 (Slc1a2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,089.00
  OriGene Technologies, Inc.

18 Item(s)

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