SLC25A7 / UCP1 antibody

Principal name

SLC25A7 / UCP1 antibody

Alternative names for SLC25A7 / UCP1 antibody

UCP 1, UCP-1, Thermogenin, Solute carrier family 25 member 7, Mitochondrial brown fat uncoupling protein 1

SwissProt ID

P04633 (Rat), P10861 (Bovin), P12242 (Mouse), P14271 (Rabit), P25874 (Human), Q9GMZ1 (Canfa)

Gene ID

7350 (UCP1), 24860 (Ucp1)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Mky (Monkey), Ms (Mouse), Rb (Rabbit), Rt (Rat), Sh (Sheep)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of SLC25A7 / UCP1 antibody

Mitochondrial oxidative phosphorylation makes possible ATP synthesis using the energy available from substrate oxidation at the respiratory chain. These processes are coupled through the proton electrochemical potential gradient generated during the transfer of electrons from the substrate to oxygen. The uncoupling proteins (UCPs) are mitochondrial inner membrane proteins that are considered to be transporters functioning as enzymatic uncouplers of oxidative phosphorylation. They are capable of returning protons pumped by the respiratory chain to the mitochondrial matrix. Uncoupling proteins currently comprise UCP1, UCP2, UCP3, UCP4, and UCP5. UCP1 is a 32 kDa protein that is active as a proton channelforming dimer. It can bind purine nucleotides and is capable of being stimulated by fatty acids. Proton transport by UCP1 has been shown to depend on CoQ (ubiquinone) as an obligatory cofactor. UCP1 is exclusively expressed in BAT in rodents and in neonates where it is regulated by norepinephrine and thyroid hormones. Stimulated BAT is able to dissipate energy as heat via uncoupled mitochondrial respiration. The liberated heat can serve several physiological functions, e.g. for body heating during emergence from hibernation or during cold exposure, for burning body fat and consequently for body weight regulation.

General readings

Ishigaki Y, Katagiri H, Yamada T, Ogihara T, Imai J, Uno K, Hasegawa Y, Gao J, Ishihara H, Shimosegawa T, Sakoda H, Asano T, Oka Y. Dissipating excess energy stored in the liver is a potential treatment strategy for diabetes associated with obesity. Diabetes. 2005 Feb;54(2):322-32. PMID: 15677488

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SLC25A7 / UCP1 antibody

TA303071 (1µg/ml) staining of Human Adipose lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SLC25A7 / UCP1 antibody

Western blot analysis of UCP1 in HeLa cell lysate with UCP1 antibody at 1 ug/ml. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SLC25A7 / UCP1 antibody

SLC25A7 /  UCP1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

SLC25A7 / UCP1 antibody

Detection limit for recombinant GST tagged UCP1 is approximately 0.3ng/ml as a capture antibody. Mouse IgG2a 4E5 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SLC25A7 / UCP1 antibody

UCP1 monoclonal antibody (M03), clone 4B7. Western Blot analysis of UCP1 expression in NIH/3T3 ( Cat # L018V1 ). Mouse IgG2a 4B7 Purified Hu, Ms E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SLC25A7 / UCP1 antibody

SLC25A7 /  UCP1 Mouse IgG2a 4B7 Hu, Ms E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

SLC25A7 / UCP1 antibody

UCP1 polyclonal antibody ( Cat # PAB6905 ) ( 1 µg/ml ) staining of human adipose lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

SLC25A7 / UCP1 antibody

SLC25A7 /  UCP1 Rabbit IgG Aff - Purified Hu WB
0.1 mg / €290.00
  Boster Immunoleader

SLC25A7 / UCP1 antibody

SLC25A7 /  UCP1 Rabbit IgG Aff - Purified Ms, Rt WB
0.1 mg / €290.00
  Boster Immunoleader

SLC25A7 / UCP1 antibody

Western Blot: UCP1 Antibody [NB100-2828] - NB100-2828 (1ug/ml) staining of Human Adipose lysate (35ug protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SLC25A7 / UCP1

SLC25A7 /  UCP1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

SLC25A7 / UCP1

SLC25A7 /  UCP1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

UCP1 overexpression lysate

UCP1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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